PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FZR1	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKA	1	NAT2	0	two hybrid	Arroyo R (2015)	1
NAT2	0	STARD7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAT2	0	KLK5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PALB2	3	NAT2	0	two hybrid	Arroyo R (2015)	1
ERBB2	6	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
WT1	1	NAT2	0	two hybrid	Arroyo R (2015)	1
APC	5	NAT2	0	two hybrid	Arroyo R (2015)	1
AURKA	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPM1D	11	NAT2	0	two hybrid	Arroyo R (2015)	1
ERBB2	6	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKA	1	KLK5	1	two hybrid	Arroyo R (2015)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FZR1	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAD51	3	NAT2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015), Arroyo R (2015)	3
ERBB2	6	CDKN2C	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HMMR	1	NAT2	0	two hybrid	Arroyo R (2015)	1
CDKN2A	1	IGF1R	5	genetic interference	Shen JP (2017)	1
IGF1R	5	APP	1	pull down	Olah J (2011)	1
ATM	9	NAT2	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
FZR1	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	KLK5	1	two hybrid	Arroyo R (2015)	1
STK11	2	NAT2	0	two hybrid	Arroyo R (2015)	1
NAT2	0	APP	1	pull down	Olah J (2011)	1
NAT2	0	ZNF346	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FZR1	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	NAT2	0	two hybrid	Arroyo R (2015)	1
WT1	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IGF1R	5	NAT2	0	two hybrid	Arroyo R (2015)	1
PALB2	3	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dray E (2010), Hayakawa T (2010), Zhang F (2009), Zhang F (2009), Xia B (2006), Anantha RW (2013), Bleuyard JY (2012), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Foo TK (2017), Foo TK (2017)	18
BAG4	2	NAT2	0	two hybrid	Arroyo R (2015)	1
CDKN2A	1	NAT2	0	two hybrid	Arroyo R (2015)	1
STK11	2	APP	1	pull down	Olah J (2011)	1
BAG4	2	KLK5	1	two hybrid	Arroyo R (2015)	1
FZR1	1	NAT2	0	two hybrid	Arroyo R (2015)	1
CDKN2A	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ATM	9	CDKN2C	0	affinity chromatography technology, pull down	Park BJ (2005), Park BJ (2005)	2
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
AURKA	1	HMMR	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Maxwell CA (2011)	3
ATM	9	NBN	1	unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Cariveau MJ (2007), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Wu J (2012), Wei F (2015)	12
AURKA	1	CDKN2A	1	affinity chromatography technology	Ewing RM (2007)	1
CDKN2C	0	NAT2	0	two hybrid	Arroyo R (2015)	1
NBN	1	NAT2	0	two hybrid	Arroyo R (2015)	1
RAD51	3	ATM	9	affinity chromatography technology, affinity chromatography technology	Chen G (1999), Chen G (1999)	2
CDKN2C	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IGF1R	5	KLK5	1	two hybrid	Arroyo R (2015)	1