PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NR2E3	2	IRF9	0	two hybrid	Ravasi T (2010)	1
ZNF232	1	NR2E3	2	two hybrid	Ravasi T (2010)	1
POLR3D	0	NR2E3	2	two hybrid	Ravasi T (2010)	1
PPARG	0	VDR	2	pull down, affinity chromatography technology	Alimirah F (2012), Alimirah F (2012)	2
NR3C1	2	RBFOX2	5	bioid	Lempiaeinen JK (2017)	1
PPARG	0	NR2E3	2	two hybrid	Ravasi T (2010)	1
NR2E3	2	RXRA	1	pull down	Chen F (1999)	1
SNAPC1	0	NR2E3	2	two hybrid	Ravasi T (2010)	1
CRX	0	NRL	0	fluorescent resonance energy transfe	von Alpen D (2015)	1
NR2E3	2	NR1D1	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
NR2E3	2	DEDD2	1	two hybrid	Ravasi T (2010)	1
VDR	2	RXRA	1	pull down, two hybrid, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique, imaging technique, pull down, pull down, pull down, pull down, pull down, two hybrid, pull down, two hybrid, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, imaging technique, two hybrid, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Baudino TA (1998), Baudino TA (1998), Zhang C (2001), Song CS (2006), Dunlop TW (2005), Ting HJ (2005), Kim S (2005), Kim S (2005), Solomon C (2001), Liu YY (2000), Liu YY (2000), Rachez C (2000), Jimenez-Lara AM (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Ismail A (2004), Carvallo L (2008), Peleg S (2010), Albers M (2005), Herdick M (2000), Pedigo NG (2005), Hsieh JC (2003), Sorg BL (2006), Seuter S (2007), Seuter S (2007), Wang J (2011), Bartik L (2010), Rochel N (2011), Molnar F (2005), Ahmad K (2015), Ahmad K (2015)	32
NR2E3	2	RBFOX2	5	two hybrid	Ravasi T (2010)	1
NR2E3	2	BCL11A	14	pull down, two hybrid, affinity chromatography technology, two hybrid	Chan CM (2013), Chan CM (2013), Chan CM (2013), Chan CM (2013)	4
ELAVL2	4	NR2E3	2	two hybrid	Ravasi T (2010)	1
NR3C1	2	NR2E3	2	two hybrid	Ravasi T (2010)	1
NR2E3	2	CRX	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
NR2E3	2	NRL	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
ELAVL2	4	RBFOX2	5	two hybrid	Ravasi T (2010)	1
VDR	2	NR2E3	2	imaging technique	Vaeisaenen S (2005)	1
POLR3D	0	RBFOX2	5	two hybrid	Ravasi T (2010)	1
RBFOX2	5	DEDD2	1	two hybrid	Ravasi T (2010)	1
HOXC13	0	NR2E3	2	two hybrid	Ravasi T (2010)	1
NR2E3	2	NR2E3	2	fluorescent resonance energy transfe	von Alpen D (2015)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
NR2E3	2	RARA	5	pull down	Chen F (1999)	1