PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
ELAVL1	0	HIF1AN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HIF1AN	0	ZBTB33	1	affinity chromatography technology	Rodriguez J (2016)	1
FBXL17	4	ZBTB33	1	affinity chromatography technology	Raducu M (2016)	1
ZBTB33	1	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology	Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011)	3
SUMO2	0	GATAD2B	15	pull down	Ouyang J (2009)	1
HDAC3	5	HIF1AN	0	pull down, affinity chromatography technology	Mahon PC (2001), Rodriguez J (2016)	2
ZBTB33	1	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
TP53	0	WWOX	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Chang NS (2001), Chang NS (2001), Chang NS (2005), Chang NS (2005), Chang NS (2005)	5
TXNIP	2	GATAD2B	15	affinity chromatography technology	Huttlin EL (2017)	1
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
HUWE1	22	KLF16	1	affinity chromatography technology	Hein MY (2015)	1
WDR48	2	TP53	0	affinity chromatography technology	Sowa ME (2009)	1
DCN	0	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	HDAC3	5	affinity chromatography technology	Rodriguez J (2016)	1
FOXB1	1	TP53	0	affinity chromatography technology	Li X (2015)	1
ZBTB33	1	CLPTM1L	1	affinity chromatography technology	Hein MY (2015)	1
ZBTB33	1	SGF29	0	affinity chromatography technology	Hein MY (2015)	1
KPNA2	0	ZBTB33	1	affinity chromatography technology, affinity chromatography technology	Kelly KF (2004), Kelly KF (2004)	2
HDAC3	5	SF3B1	12	affinity chromatography technology	Ewing RM (2007)	1
ZBTB33	1	TCF7L2	12	pull down, affinity chromatography technology, affinity chromatography technology	Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011)	3
ELAVL1	0	ZBTB33	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ZBTB33	1	TRMT10A	0	affinity chromatography technology	Hein MY (2015)	1
SF3B1	12	KPNA2	0	biochemical	Wan C (2015)	1
ZBTB33	1	TRIML2	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HUWE1	22	KPNA2	0	affinity chromatography technology	Thompson JW (2014)	1
KPNA2	0	RELA	1	pull down, two hybrid	Cunningham MD (2003), Wang J (2011)	2
KAT5	1	HDAC3	5	affinity chromatography technology	Yi J (2014)	1
ZBTB33	1	KLF16	1	affinity chromatography technology	Hein MY (2015)	1
LMNA	2	KAT5	1	two hybrid	Stelzl U (2005)	1
CTNNB1	30	FOXM1	3	affinity chromatography technology	Chen Y (2016)	1
SUMO2	0	ZBTB33	1	pull down	Ouyang J (2009)	1
TCF7L2	12	EP300	36	affinity chromatography technology	Shekhar MP (2006)	1
FOXB1	1	HUWE1	22	affinity chromatography technology	Li X (2015)	1
LMNA	2	WWOX	3	bioid, bioid	Roux KJ (2012), Kim DI (2014)	2
EGLN3	0	CTNND1	4	affinity chromatography technology	Rodriguez J (2016)	1
KLF16	1	EP300	36	affinity chromatography technology	Daftary GS (2011)	1
FOXQ1	0	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
EP300	36	KPNA2	0	enzymatic study	Bannister AJ (2000)	1
ZBTB33	1	CCDC61	2	affinity chromatography technology	Hein MY (2015)	1
KLHL22	3	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	CTNND1	4	affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Kucerova D (2001)	2
FOXH1	1	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
FOXG1	26	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
SUMO2	0	CTNND1	4	pull down	Ouyang J (2009)	1
FOXP3	1	RELA	1	affinity chromatography technology	Bettelli E (2005)	1
FOXQ1	0	TP53	0	affinity chromatography technology	Li X (2015)	1
HIF1AN	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
FOXA3	0	KLF16	1	affinity chromatography technology	Li X (2015)	1
KAT5	1	FOXP3	1	affinity chromatography technology, affinity chromatography technology	Li B (2007), van Loosdregt J (2010)	2
ZBTB33	1	RELA	1	affinity chromatography technology, affinity chromatography technology	Koh DI (2015), Koh DI (2015)	2
LMNA	2	CTNNB1	30	affinity chromatography technology	Choi J (2004)	1
FOXG1	26	FOXH1	1	affinity chromatography technology, two hybrid	Dou C (2000), Ravasi T (2010)	2
NCOR1	9	EP300	36	affinity chromatography technology	Cowger JJ (2006)	1
TCF7L2	12	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lukas J (2009), Idogawa M (2007), Hong CF (2009), Del Valle-Perez B (2011), Tzeng SL (2006), Tzeng SL (2006), Satow R (2012), Satow R (2012), Graham TA (2001), Sato S (2005), Mosimann C (2006), Shekhar MP (2006), Hsu MC (2007), Loregger A (2015), Hanson AJ (2012), Kuslansky Y (2016)	16
EGLN3	0	ZBTB33	1	affinity chromatography technology	Rodriguez J (2016)	1
WWOX	3	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
CTCF	15	KPNA2	0	affinity chromatography technology	Yusufzai TM (2004)	1
PFDN4	0	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
ZBTB33	1	CTNND2	2	affinity chromatography technology	Dai SD (2011)	1
XAGE1B	0	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
FOXB1	1	SF3B1	12	affinity chromatography technology	Li X (2015)	1
IL17RA	3	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
ZBTB33	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Koh DI (2014), Koh DI (2014)	2
ZNF576	2	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXA3	0	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ELAVL1	0	TXNIP	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
FOXG1	26	TP53	0	affinity chromatography technology	Li X (2015)	1
ZBTB33	1	KAT5	1	affinity chromatography technology	Koh DI (2014)	1
PCGF6	0	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
CBFA2T3	3	ZBTB33	1	two hybrid, affinity chromatography technology	Barrett CW (2012), Barrett CW (2012)	2
WDR48	2	CTNND1	4	affinity chromatography technology	Sowa ME (2009)	1
CBFA2T3	3	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Hoogeveen AT (2002), Amann JM (2001)	2
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
WDR48	2	ZBTB33	1	affinity chromatography technology	Sowa ME (2009)	1
VWCE	5	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
KAT5	1	RELA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Kim JW (2012), Kim JW (2012), Kim JW (2012)	3
LMNA	2	ELAVL1	0	affinity chromatography technology	Depreux FF (2015)	1
ZBTB33	1	DPH7	1	affinity chromatography technology	Hein MY (2015)	1
ZBTB33	1	TP53	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Koh DI (2014), Koh DI (2014), Koh DI (2014), Koh DI (2015), Koh DI (2015)	5
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
HUWE1	22	ZBTB33	1	affinity chromatography technology	Thompson JW (2014)	1
GATAD2B	15	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
HUWE1	22	WWOX	3	affinity chromatography technology	Thompson JW (2014)	1
TXNIP	2	ZBTB33	1	bioid	Forred BJ (2016)	1
FOXG1	26	GATAD2B	15	affinity chromatography technology	Li X (2015)	1
SUMO2	0	TRIML2	0	pull down	Ouyang J (2009)	1
EGLN3	0	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
DEFA5	1	ZBTB33	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SUMO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CTNND1	4	ZBTB33	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Daniel JM (1999), Daniel JM (1999), Ruzov A (2004), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Dai SD (2010), Dai SD (2010), Kelly KF (2004), Kelly KF (2004), Zhang J (2010), Jiang G (2012), Liu Y (2014)	14
TP53	0	TXNIP	2	affinity chromatography technology	Suh HW (2013)	1
FOXB1	1	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
FOXB1	1	CTNNB1	30	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	PCGF6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
IL17RA	3	HDAC3	5	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
FOXP3	1	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
FHL5	0	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
NCOR1	9	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Amann JM (2001), Olsson A (2008)	2
FOXQ1	0	GATAD2B	15	affinity chromatography technology	Li X (2015)	1
TXNIP	2	RELA	1	affinity chromatography technology	Kwon HJ (2010)	1
WWOX	3	SF3B1	12	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
HDAC3	5	ZBTB33	1	affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003)	2
EGLN3	0	NCOR1	9	affinity chromatography technology	Rodriguez J (2016)	1
FOXA3	0	FOXP3	1	affinity chromatography technology	Li X (2015)	1
EP300	36	KAT5	1	affinity chromatography technology, affinity chromatography technology	Col E (2005), Col E (2005)	2
TRIM10	3	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
ZBTB33	1	SF3B1	12	affinity chromatography technology	Hein MY (2015)	1
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
EP300	36	FOXP3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	van Loosdregt J (2010), van Loosdregt J (2010), Grant C (2006)	3
ELAVL1	0	TCF7L2	12	affinity chromatography technology	Abdelmohsen K (2009)	1
TXNIP	2	HDAC3	5	pull down	Kwon HJ (2010)	1
ENPP6	1	ZBTB33	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXQ1	0	SF3B1	12	affinity chromatography technology	Li X (2015)	1
RELA	1	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Chen Lf (2001), Hu J (2004), Hu J (2004)	4
WWOX	3	ELAVL1	0	affinity chromatography technology	Abu-Odeh M (2014)	1
TRPV5	2	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
LMNA	2	SF3B1	12	affinity chromatography technology	Depreux FF (2015)	1
HUWE1	22	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Thompson JW (2014), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017)	4
FOXA3	0	TP53	0	affinity chromatography technology	Li X (2015)	1
EGLN3	0	RELA	1	affinity chromatography technology	Rodriguez J (2016)	1
EP300	36	SUMO2	0	pull down, enzymatic study	Ullmann R (2012), Ullmann R (2012)	2
ZBTB33	1	CTCF	15	affinity chromatography technology	Defossez PA (2005)	1
FOXB1	1	CTNND1	4	affinity chromatography technology	Li X (2015)	1
IL17RA	3	NCOR1	9	affinity chromatography technology	Huttlin EL (2017)	1
LMNA	2	ZBTB33	1	bioid	Roux KJ (2012)	1
HIF1AN	0	RELA	1	affinity chromatography technology	Rodriguez J (2016)	1
CTCF	15	LMNA	2	affinity chromatography technology	Yusufzai TM (2004)	1
EGLN3	0	KLF16	1	affinity chromatography technology	Rodriguez J (2016)	1
NCOR1	9	ZBTB33	1	affinity chromatography technology, affinity chromatography technology, pull down	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003)	3
TP53	0	NCOR1	9	affinity chromatography technology, imaging technique	Dohi Y (2008), Ali A (2013)	2