PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATF3	0	ATF2	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Ravasi T (2010), Reinke AW (2013), Reinke AW (2013)	3
ATF2	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
NR3C1	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
CEBPA	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
HDAC2	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Itoh Y (2007), Tarallo R (2011)	2
ALX1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FGFR1OP	0	NR3C1	2	bioid	Gupta GD (2015)	1
CREB1	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Kim HC (2010)	2
EGR1	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ATF2	1	CREB1	1	biochemical	Wan C (2015)	1
ESR1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ATF4	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
EGR2	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ATF2	1	FOS	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hai T (1991), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Rolland T (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	8
ESR2	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
NR3C1	2	SPEN	22	bioid	Lempiaeinen JK (2017)	1
ETS2	1	ETS1	4	pull down	Basuyaux JP (1997)	1
ATF2	1	CEBPA	0	two hybrid	Hong S (2004)	1
NR3C1	2	HDAC2	1	affinity chromatography technology	Ito K (2000)	1
CREB1	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FOS	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
FOSL2	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ATF4	2	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	GTF2B	1	pull down	Liang G (1997)	1
GTF2B	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ESRRG	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FGFR1OP	0	SRA1	0	bioid	Gupta GD (2015)	1
SRA1	0	HDAC2	1	affinity chromatography technology	Chooniedass-Kothari S (2010)	1
NR3C1	2	CREB1	1	pull down, affinity chromatography technology	Imai E (1993), Guo C (2010)	2
DDIT3	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
DMTF1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
BLZF1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
OAZ1	2	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
ATF3	0	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
FOS	0	ESR1	0	affinity chromatography technology	Baron S (2007)	1
GTF3C5	4	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
CREB1	1	ATF1	0	affinity chromatography technology	Li X (2015)	1
DDIT3	1	ATF2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
ATF3	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
DDIT3	1	CEBPA	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Marwarha G (2016), Marwarha G (2016), Marwarha G (2016)	3
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
ATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HAND1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
DDIT3	1	FOS	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
FOSB	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
POLK	0	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
ATF4	2	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	3
ESR1	0	GTF2B	1	pull down	Lazennec G (1997)	1
SPEN	22	SRA1	0	pull down, affinity chromatography technology	Shi Y (2001), Shi Y (2001)	2
TIGD6	0	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
SRA1	0	UBE2T	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MLKL	1	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
GATA1	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ETS2	1	GTF3C5	4	affinity chromatography technology	Hein MY (2015)	1
NR3C1	2	ETS2	1	affinity chromatography technology	Mullick J (2001)	1
CEBPA	0	NR3C1	2	pull down	Boruk M (1998)	1
ETS1	4	ATF2	1	pull down	Giese K (1995)	1
BTG2	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
CEBPA	0	ESR1	0	pull down	Boruk M (1998)	1
RUFY1	4	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
ATF1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
DDIT3	1	FOSL2	2	two hybrid	Rolland T (2014)	1
EGR1	1	FOSL2	2	affinity chromatography technology	Hein MY (2015)	1
ATF2	1	ATF1	0	biochemical	Wan C (2015)	1
ETS2	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FOS	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FOSL2	2	RUFY1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SAP30	1	HDAC2	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Zhang Y (1999), Kuzmichev A (2002), Viiri KM (2006), Lai A (2001), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Bantscheff M (2011), Hein MY (2015)	11
ETS2	1	FOS	0	pull down	Basuyaux JP (1997)	1
FOSL2	2	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATF4	2	ATF2	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NR3C1	2	TFAP2A	1	bioid	Lempiaeinen JK (2017)	1
GTF2H2	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ATF1	0	FOSL2	2	biochemical	Havugimana PC (2012)	1
TFAP2A	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
E2F3	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ATF4	2	ATF3	0	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wang Q (2009), Reinke AW (2013), Reinke AW (2013)	3
ETS1	4	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
SAP30	1	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
FOS	0	FOSB	0	affinity chromatography technology	Li X (2015)	1
CEBPA	0	HDAC2	1	affinity chromatography technology	Duan H (2005)	1