PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCL2	0	CASP8	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Poulaki V (2001), Guo Y (2002), Zhu J (2005), Zhu J (2005)	4
NR4A1	4	BCL2	0	pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lin B (2004), Lin B (2004), Lin B (2004), Lin B (2004), Lin B (2004), Han YH (2006), Kolluri SK (2008), Kolluri SK (2008)	8
BCL2L10	0	BCL2L10	0	affinity chromatography technology	Ke N (2001)	1
BAX	3	CASP8	1	biochemical	Chandra D (2004)	1
BCL2L10	0	BCL2	0	affinity chromatography technology	Ke N (2001)	1
BCL2L10	0	NR4A1	4	affinity chromatography technology	Kolluri SK (2008)	1
CASP8	1	BCL2L10	0	two hybrid	Arroyo R (2015)	1
BCL2L10	0	BAX	3	affinity chromatography technology	Ke N (2001)	1
BCL2	0	BAX	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoetelmans RW (2004), Lin B (2004), Lin B (2004), Oltvai ZN (1993), Komatsu K (2000), Geng F (2011), Bodur C (2012), Trisciuoglio D (2013), Zhang H (2000), Diaz JL (1997), Dlugosz PJ (2006), Konopleva M (2006), Konopleva M (2006), Czabotar PE (2011)	14
UBQLN1	1	BCL2L10	0	affinity chromatography technology, affinity chromatography technology	Beverly LJ (2012), Kurlawala Z (2017)	2