PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRMS1	1	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Meehan WJ (2004), Hein MY (2015)	3
SIN3A	13	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Fleischer TC (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Yochum GS (2001), Kuzmichev A (2002), Kuzmichev A (2002), Kuzmichev A (2002), Laherty CD (1998), Viiri KM (2006), Viiri KM (2006), Nakamura T (2002), Lai A (2001), Skowyra D (2001), Zhang Y (1998), Zhang Y (1998), Xie T (2011), Xie T (2011), Bantscheff M (2011), Hein MY (2015)	21
SIN3B	5	SIN3A	13	affinity chromatography technology	Hein MY (2015)	1
CDK4	2	RFC1	1	affinity chromatography technology	van der Kuip H (1999)	1
DNAJA2	2	XPO1	8	biochemical	Wan C (2015)	1
SAP25	1	SIN3A	13	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shiio Y (2006), Shiio Y (2006), Shiio Y (2006), Shiio Y (2006), Shiio Y (2006)	5
SAP25	1	IFIT1	0	affinity chromatography technology	Shiio Y (2006)	1
SAP30	1	SAP130	2	affinity chromatography technology	Hein MY (2015)	1
SAP25	1	PRKDC	12	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	GTF2B	1	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	RACK1	2	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	OGT	4	affinity chromatography technology	Shiio Y (2006)	1
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
SAP25	1	SAP30	1	affinity chromatography technology	Shiio Y (2006)	1
HNRNPA1	1	PTBP1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Close P (2012), Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Wan C (2015)	5
SAP25	1	DNAJA2	2	affinity chromatography technology	Shiio Y (2006)	1
SIN3B	5	SAP130	2	affinity chromatography technology	Hein MY (2015)	1
SAP25	1	KPNA2	0	affinity chromatography technology	Shiio Y (2006)	1
SAP30	1	RBBP7	1	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Kuzmichev A (2002), Lai A (2001), Zhang Y (1998), Zhang Y (1998), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	11
IFIT1	0	IFIT3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid	Rual JF (2005), Pichlmair A (2011), Pichlmair A (2011), Pichlmair A (2011), Pichlmair A (2011), Pichlmair A (2011), Rolland T (2014), Yu H (2011)	8
SAP25	1	SIN3B	5	affinity chromatography technology	Shiio Y (2006)	1
RBBP7	1	SIN3B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	4
SAP25	1	SAP130	2	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	IFIT3	1	affinity chromatography technology	Shiio Y (2006)	1
BRMS1	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
BRMS1	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hurst DR (2006), Bantscheff M (2011), Joshi P (2013), Meehan WJ (2004), Meehan WJ (2004)	5
SAP25	1	RFC1	1	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	ZC3HAV1	4	affinity chromatography technology	Shiio Y (2006)	1
CDK4	2	PRKDC	12	genetic interference	Shen JP (2017)	1
SAP25	1	XPO1	8	affinity chromatography technology	Shiio Y (2006)	1
HDAC2	1	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu WS (2001), Morey L (2008), Kraemer OH (2008), Kim YE (2015)	4
SAP25	1	TTLL12	3	affinity chromatography technology	Shiio Y (2006)	1
SIN3A	13	BRMS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hurst DR (2013), Meehan WJ (2004), Meehan WJ (2004)	4
SAP25	1	CDKN2A	1	affinity chromatography technology	Shiio Y (2006)	1
XPO1	8	ZC3HAV1	4	affinity chromatography technology	Kirli K (2015)	1
SAP25	1	PPP1R14C	0	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	HDAC2	1	affinity chromatography technology	Shiio Y (2006)	1
CDKN2A	1	PML	7	affinity chromatography technology, affinity chromatography technology, imaging technique	Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	3
SAP25	1	LPCAT1	1	affinity chromatography technology	Shiio Y (2006)	1
SIN3A	13	TTLL12	3	biochemical	Havugimana PC (2012)	1
SIN3A	13	OGT	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Yang X (2002), Yang X (2002), Yang X (2002), Whisenhunt TR (2006)	4
PML	7	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Khan MM (2001)	2
SAP25	1	DDX3Y	0	affinity chromatography technology	Shiio Y (2006)	1
RBBP7	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Kuzmichev A (2002), Nakamura T (2002), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
RBBP7	1	SAP130	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKDC	12	HNRNPA1	1	enzymatic study	Zhang S (2004)	1
SAP30	1	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Hein MY (2015), Hein MY (2015)	3
SIN3B	5	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Romm E (2005), Bantscheff M (2011)	2
HDAC2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Adenuga D (2010), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016)	9
SAP25	1	RBBP7	1	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	CDK4	2	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	SEH1L	1	affinity chromatography technology	Shiio Y (2006)	1
PML	7	SAP130	2	affinity chromatography technology	McNamara S (2008)	1
SAP130	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fleischer TC (2003), Xue Y (1998), Joshi P (2013)	3
SAP30	1	HDAC2	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Zhang Y (1999), Kuzmichev A (2002), Viiri KM (2006), Lai A (2001), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Bantscheff M (2011), Hein MY (2015)	11
HNRNPA1	1	RACK1	2	affinity chromatography technology	Roy R (2014)	1
SAP25	1	PTBP1	2	affinity chromatography technology	Shiio Y (2006)	1
IFIT3	1	HNRNPA1	1	affinity chromatography technology	Pichlmair A (2011)	1
XPO1	8	HNRNPA1	1	affinity chromatography technology	Kirli K (2015)	1
SIN3A	13	SAP130	2	affinity chromatography technology, affinity chromatography technology, biochemical	Fleischer TC (2003), Fleischer TC (2003), Wan C (2015)	3
SAP25	1	BRMS1	1	affinity chromatography technology	Shiio Y (2006)	1
SAP25	1	PML	7	affinity chromatography technology	Shiio Y (2006)	1
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20
BRMS1	1	SIN3B	5	affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Meehan WJ (2004)	2
SAP25	1	HNRNPA1	1	affinity chromatography technology	Shiio Y (2006)	1