PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
VCP	6	TOM1	3	affinity chromatography technology	Yu CC (2013)	1
SSBP2	2	TOM1	3	two hybrid	Wang J (2011)	1
SMURF1	4	UBE2D1	0	pull down, enzymatic study	Kristariyanto YA (2015), Andrews PS (2010)	2
EGLN3	0	YAP1	0	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
SMURF1	4	TOM1	3	enzymatic study	Andrews PS (2010)	1
PRKN	1	MYO6	3	affinity chromatography technology	Sarraf SA (2013)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
PRKN	1	RAC1	7	two hybrid	Stelzl U (2005)	1
NTRK1	1	TBCD	4	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
EGLN3	0	ZFYVE16	6	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	MYO6	3	affinity chromatography technology	Fei T (2017)	1
EGLN3	0	RAC1	7	affinity chromatography technology	Rodriguez J (2016)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
RAC1	7	NEDD4	2	affinity chromatography technology, pull down	Nethe M (2012), Nethe M (2012)	2
NTRK1	1	CLTC	12	affinity chromatography technology	Emdal KB (2015)	1
TOM1	3	TSG101	1	affinity chromatography technology	Yanagida-Ishizaki Y (2008)	1
HIST1H1E	5	TOM1	3	biochemical	Kristensen AR (2012)	1
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
DDI2	2	TOM1	3	biochemical	Wan C (2015)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
HIST1H1E	5	EXOSC4	1	biochemical	Kristensen AR (2012)	1
TOM1	3	TOLLIP	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down	Yamakami M (2003), Yamakami M (2003), Yamakami M (2003), Katoh Y (2006), Katoh Y (2004), Rolland T (2014), Katoh Y (2004), Xiao S (2015), Xiao S (2015)	9
HNRNPL	3	SMURF1	4	affinity chromatography technology	Fei T (2017)	1
TBCD	4	WDR12	0	biochemical	Kristensen AR (2012)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
ZFYVE16	6	APP	1	pull down	Olah J (2011)	1
RAC1	7	TOM1	3	affinity chromatography technology	Visvikis O (2011)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
GARS	1	TOM1	3	biochemical	Kristensen AR (2012)	1
UBC	7	DDI2	2	pull down	Zhang X (2017)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	CLTC	12	affinity chromatography technology	Xie Y (2013)	1
LITAF	0	TSG101	1	affinity chromatography technology, affinity chromatography technology	Shirk AJ (2005), Li W (2015)	2
PRKN	1	TOM1	3	affinity chromatography technology	Sarraf SA (2013)	1
UBC	7	MYO6	3	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Bish RA (2007), He F (2016), He F (2016), Zhang X (2017)	5
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
PTBP2	1	TOM1	3	two hybrid	Wang J (2011)	1
TOM1	3	ME1	1	biochemical	Kristensen AR (2012)	1
LITAF	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shirk AJ (2005), Li W (2015), Huttlin EL (2017)	3
WDR12	0	TOM1	3	biochemical	Kristensen AR (2012)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
ZFYVE16	6	TOM1	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Seet LF (2004), Seet LF (2004), Seet LF (2004), Seet LF (2004)	4
RAC1	7	CLTC	12	affinity chromatography technology	Visvikis O (2011)	1
TBCD	4	TOM1	3	biochemical	Kristensen AR (2012)	1
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
TOLLIP	3	RAC1	7	affinity chromatography technology, affinity chromatography technology	Visvikis O (2011), Visvikis O (2011)	2
TSG101	1	WDR12	0	biochemical	Havugimana PC (2012)	1
HNRNPL	3	PTBP2	1	affinity chromatography technology	Fei T (2017)	1
TBCD	4	APP	1	pull down	Olah J (2011)	1
XPO1	8	TOM1	3	affinity chromatography technology	Kirli K (2015)	1
IL1R1	0	TOLLIP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Brissoni B (2006)	3
MYO19	0	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
MAP3K1	4	TOM1	3	enzymatic study	Charlaftis N (2014)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
MYO6	3	CLTC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buss F (2001), Hein MY (2015), Wollscheid HP (2016)	3
EGLN3	0	MYO6	3	affinity chromatography technology	Rodriguez J (2016)	1
MYO6	3	TOM1	3	affinity chromatography technology, two hybrid	Tumbarello DA (2012), Tumbarello DA (2012)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
XPO1	8	YAP1	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	TOLLIP	3	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
TOM1	3	UBE2D1	0	pull down	Singh RK (2009)	1
SMURF1	4	VCP	6	affinity chromatography technology	Xie Y (2013)	1
ILVBL	4	TOM1	3	two hybrid	Wang J (2011)	1
MYO19	0	MYO6	3	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	TOM1	3	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	TOM1	3	affinity chromatography technology	Fei T (2017)	1
TOM1	3	YAP1	0	biochemical	Kristensen AR (2012)	1
RPS27	0	TOM1	3	two hybrid	Wang J (2011)	1
ZNF512B	2	TOM1	3	two hybrid	Colland F (2004)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
RAC1	7	MYO19	0	affinity chromatography technology	Boldt K (2016)	1
VCP	6	TSG101	1	affinity chromatography technology	Yu CC (2013)	1
NTRK1	1	TSG101	1	affinity chromatography technology	Emdal KB (2015)	1
NEDD4	2	TOM1	3	enzymatic study	Persaud A (2009)	1
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
LITAF	0	TOM1	3	affinity chromatography technology	Li W (2015)	1
ME1	1	TBCD	4	biochemical	Kristensen AR (2012)	1
YAP1	0	HIST1H1E	5	affinity chromatography technology	Enzo E (2015)	1
NTRK1	1	ILVBL	4	affinity chromatography technology	Emdal KB (2015)	1
MYO19	0	TOM1	3	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	EXOSC4	1	affinity chromatography technology	Emdal KB (2015)	1
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
HNRNPL	3	TBCD	4	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
WDR12	0	XPO1	8	biochemical	Havugimana PC (2012)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
YAP1	0	VCP	6	affinity chromatography technology	Enzo E (2015)	1
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
GARS	1	ME1	1	biochemical	Kristensen AR (2012)	1
NTRK1	1	MYO6	3	affinity chromatography technology	Emdal KB (2015)	1
RAC1	7	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
UBC	7	TOM1	3	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Akutsu M (2005), Akutsu M (2005), Nathan JA (2013), Bish RA (2007), Katoh Y (2004), Xiao S (2015), Zhang X (2017)	8
IL1R1	0	TOM1	3	affinity chromatography technology	Brissoni B (2006)	1
EGLN3	0	TSG101	1	affinity chromatography technology	Rodriguez J (2016)	1
TOM1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology, pull down	Yamakami M (2003), Katoh Y (2006), Seet LF (2005)	3
TOM1	3	APP	1	pull down	Olah J (2011)	1
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
UBE2D1	0	YAP1	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	TOM1	3	affinity chromatography technology	Rodriguez J (2016)	1
TOM1	3	83475	0	biochemical	Wan C (2015)	1
EXOSC4	1	TOM1	3	biochemical	Kristensen AR (2012)	1
NTRK1	1	GARS	1	affinity chromatography technology	Emdal KB (2015)	1
NEDD4	2	HNRNPL	3	pull down	Ingham RJ (2005)	1