PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NEDD9	3	BCAR1	6	affinity chromatography technology	Law SF (1999)	1
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
SH2D3C	2	NEDD9	3	affinity chromatography technology	Sakakibara A (2000)	1
SH2D3C	2	EFS	2	two hybrid	Rual JF (2005)	1
SH2D3C	2	BCAR1	6	affinity chromatography technology	Sakakibara A (2000)	1
NEDD9	3	LYN	2	pull down, affinity chromatography technology	Manie SN (1997), Manie SN (1997)	2
SNCAIP	2	SH2D3C	2	two hybrid	Stelzl U (2005)	1
LYN	2	BCAR1	6	affinity chromatography technology, affinity chromatography technology	Manie SN (1997), Qiu W (1998)	2
BCAR1	6	EFS	2	two hybrid	Stelzl U (2005)	1
EGFR	5	SH2D3C	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
LYN	2	SH2D3C	2	affinity chromatography technology	Zhu J (2013)	1