PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK8	3	BCAR1	6	affinity chromatography technology	Girardin SE (2001)	1
SH2D3A	3	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Lu Y (1999), Lu Y (1999), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
NXF1	0	ERBB2	6	affinity chromatography technology	Castello A (2012)	1
SFN	1	BCAR1	6	affinity chromatography technology	Benzinger A (2005)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
NXF1	0	SH2D3A	3	pull down	Grant RP (2002)	1
SH2D3A	3	BCAR1	6	affinity chromatography technology	Lu Y (1999)	1
SFN	1	SH2D3A	3	affinity chromatography technology	Benzinger A (2005)	1
BCAR1	6	ERBB2	6	affinity chromatography technology	Bisaro B (2016)	1
KRAS	1	NXF1	0	genetic interference	Luo J (2009)	1
SH2D3A	3	CENPB	0	two hybrid	Grossmann A (2015)	1
MAPK8	3	SH2D3A	3	genetic interference	Lu Y (1999)	1
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
ERBB2	6	SH2D3A	3	unspecified method	Jones RB (2006)	1
EGFR	5	MAPK8	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
KRAS	1	SH2D3A	3	genetic interference	Luo J (2009)	1