PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NOD2	1	CASP12	1	affinity chromatography technology	LeBlanc PM (2008)	1
RIPK2	0	CASP12	1	affinity chromatography technology, affinity chromatography technology	LeBlanc PM (2008), LeBlanc PM (2008)	2
XIAP	0	RIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Bertrand MJ (2011), Damgaard RB (2012), Krieg A (2009), Krieg A (2009), Krieg A (2009), Conde C (2012), Damgaard RB (2013), Damgaard RB (2013), Rolland T (2014)	9
CASP12	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
CASP12	1	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
CASP12	1	MAGEA3	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Morishima N (2002), Morishima N (2002), Morishima N (2002)	3
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
HSPA5	0	CASP12	1	affinity chromatography technology	Rao RV (2002)	1
CASP12	1	CASP12	1	affinity chromatography technology, enzymatic study	Yoneda T (2001), Morishima N (2002)	2
NOD2	1	XIAP	0	affinity chromatography technology, pull down	Damgaard RB (2012), Krieg A (2009)	2
TRAF2	1	CASP12	1	affinity chromatography technology	Yoneda T (2001)	1
CASP9	6	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CASP12	1	CASP9	6	enzymatic study	Morishima N (2002)	1
UBE2K	0	CASP12	1	enzymatic study	Song S (2008)	1