Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ABCC5	10057	SILDENAFIL	CHEMBL192	inhibitor	GuideToPharmacologyInteractions
ABCC5	10057	FLUOROURACIL	CHEMBL185		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ABCC5	rs2139560	A	antiepileptics	efficacy	no	This variant was reported as G>T (minus strand) but dbSNP reports this as A>G. Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele A is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele G.	21449672	827845063
ABCC5	rs1000002	T	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele T is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C.	21449672	827845075
ABCC5	rs3792581	A	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele A is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C.	21449672	827845051
ABCC5	rs2293001	C	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele C is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele T.	21449672	827845045
ABCC5	rs4148557	G	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele A.	21449672	827845025
ABCC5	rs2293001	C	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele C is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele T.	21449672	827845039
ABCC5	rs3805111	G	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele A.	21449672	827845057
ABCC5	rs4148572	G	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C.	21449672	827845032
ABCC5	rs8180093	G	antiepileptics	efficacy	no	Epilepsy patients on antiepileptic drug (AED) treatment were divided into those with drug-responsive or drug-resistant epilepsy and genotypes and allele frequencies were compared. No significant association found with this variant.	Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele A.	21449672	827845069
ABCC5	rs1533682	TT	doxorubicin	metabolism/PK	yes	However, this association was no longer significant in multivariate analysis. Please note that alleles have been complemented to the plus chromosomal strand.	Genotype TT is associated with increased clearance of doxorubicin in women with Breast Neoplasms as compared to genotypes CC + CT.	26975227	1447959818
ABCC5	rs3749442	A	glibenclamide	efficacy	yes	No allele was given for the association, so the minor allele from dbSNP at this location was used. Response to treatment was measured as fasting plasma glucose below 7 mmol/L change after 1-year of treatment.	Allele A is associated with increased response to glibenclamide in people with as compared to allele G.	27403931	1448123675