PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HDAC2	1	MYCN	2	affinity chromatography technology	Marshall GM (2010)	1
UBL4A	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012), Xu Y (2013)	3
MYC	2	SHOC2	4	affinity chromatography technology	Koch HB (2007)	1
CDKN2A	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique	He L (2008), He L (2008), He L (2008)	3
HIST3H2BB	0	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Choi J (2011), Choi J (2011)	2
HUWE1	22	C16orf72	3	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Hein MY (2015)	2
DDIT4	0	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Thompson JW (2014)	2
HUWE1	22	OGT	4	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Hein MY (2015)	2
ATOH1	2	HUWE1	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study	Cheng YF (2016), Cheng YF (2016), Cheng YF (2016), Cheng YF (2016), Cheng YF (2016)	5
HUWE1	22	KLF4	2	enzymatic study, affinity chromatography technology	Hao Z (2017), Hao Z (2017)	2
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
CDC6	0	CDKN2A	1	pull down	Ramachandran N (2004)	1
HUWE1	22	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down	Pandya RK (2010), Parsons JL (2009), Schwarz SE (1998), Kristariyanto YA (2015), Choe KN (2016), Kurokawa M (2013)	6
USP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, pull down	Li Z (2015), Li Z (2015), Li Z (2015)	3
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
BRCA1	7	HDAC2	1	pull down, affinity chromatography technology, genetic interference	Yarden RI (1999), Chang S (2011), Shen JP (2017)	3
UBC	7	PSMB7	1	affinity chromatography technology	Matsumoto M (2005)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
MYC	2	MYCN	2	affinity chromatography technology	Li X (2015)	1
MYC	2	MCL1	1	genetic interference	Toyoshima M (2012)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
CUL4B	8	HDAC2	1	affinity chromatography technology, affinity chromatography technology, biochemical	Ji Q (2014), Ji Q (2014), Ji Q (2014)	3
CTNNB1	30	USP4	3	affinity chromatography technology, affinity chromatography technology	Yun SI (2015), Yun SI (2015)	2
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
MUTYH	1	PCNA	0	affinity chromatography technology, pull down	Parker A (2001), Parker A (2001)	2
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
DDIT4	0	DDB1	6	affinity chromatography technology	Katiyar S (2009)	1
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
USP9X	15	CTNNB1	30	affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Taya S (1999), Taya S (1999), Taya S (1999), Murray RZ (2004), Yang B (2016), Yang B (2016)	6
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
MYC	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Hwang IY (2012)	2
OGT	4	USP7	14	affinity chromatography technology, affinity chromatography technology	Ding X (2015), Ding X (2015)	2
MAPK6	1	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Rodriguez J (2016), Rodriguez J (2016)	2
MCL1	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Ding Q (2007), Ding Q (2007), Ding Q (2007)	3
UBC	7	OGT	4	pull down	Zhang X (2017)	1
MCL1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Stankiewicz AR (2009)	2
HSPB1	2	HSPA4	3	two hybrid	Katsogiannou M (2014)	1
PPP5C	2	DDB1	6	affinity chromatography technology	Yadav L (2017)	1
MDM2	2	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
MDM2	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Jacob AG (2014)	2
CDKN2A	1	PIAS2	2	affinity chromatography technology, affinity chromatography technology	Herkert B (2010), Herkert B (2010)	2
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
BRCA1	7	HSPB1	2	affinity chromatography technology	Ertych N (2016)	1
PPP5C	2	HSPA4	3	affinity chromatography technology	Zeke T (2005)	1
HIST3H2BB	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, pull down	Choi J (2011), Choi J (2011), Choi J (2011)	3
CUL4B	8	UBE2D3	1	pull down	Li X (2011)	1
CDC6	0	MYC	2	pull down	Takayama M (2000)	1
FBXW11	2	UBE2D3	1	pull down	Wu K (2010)	1
FBXW11	2	TP53	0	affinity chromatography technology	Low TY (2014)	1
BRCA1	7	UBE2D3	1	two hybrid, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down	Dynek JN (2010), Polanowska J (2006), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Calvo V (2011), Wu-Baer F (2010), Yu X (2006), Starita LM (2005), Sato K (2012), Starita LM (2004), Wei L (2011), Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Zhao GY (2007), Wenzel DM (2011), Wenzel DM (2011), McGinty RK (2014), Chen A (2002), Shabbeer S (2013), Ando K (2017)	23
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
TP53	0	PIAS2	2	pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique	Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014)	6
HUWE1	22	PCNA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Markkanen E (2011), Thompson JW (2014), Choe KN (2016), Choe KN (2016), Choe KN (2016), Choe KN (2016)	6
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
HUWE1	22	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Thompson JW (2014)	2
USP7	14	HUWE1	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Thompson JW (2014), Thompson JW (2014), Hein MY (2015)	4
UBC	7	PSMD14	3	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
CUL4B	8	USP4	3	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
ATM	9	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Mu JJ (2007), Hao Z (2012)	2
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
USP7	14	MYH9	19	affinity chromatography technology	Bhattacharya S (2015)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
MAPK6	1	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
HUWE1	22	UBE2D3	1	pull down, pull down	Yang Y (2010), Kristariyanto YA (2015)	2
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
UBC	7	UBL4A	0	affinity chromatography technology	Matsumoto M (2005)	1
HUWE1	22	PSMB7	1	affinity chromatography technology, biochemical	Thompson JW (2014), Wan C (2015)	2
BRCA1	7	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li H (2010), Li H (2010), Li H (2010), Ertych N (2016)	4
HUWE1	22	PSMD14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Jacobson AD (2014), Jacobson AD (2014)	3
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
HUWE1	22	MUTYH	1	enzymatic study, pull down, affinity chromatography technology	Dorn J (2014), Dorn J (2014), Dorn J (2014)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
PREX2	5	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Li CH (2017), Li CH (2017)	2
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
ZBTB17	2	MYC	2	pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staller P (2001), Peukert K (1997), Peukert K (1997), Peukert K (1997), Herold S (2008), Si J (2010), Si J (2010), Gordan JD (2007), Gordan JD (2007), Hervouet E (2009), Hervouet E (2009), Patel JH (2006), Patel JH (2006), Staller P (2001), Vo BT (2016), Vo BT (2016)	16
TP53	0	ZBTB17	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miao L (2010), Miao L (2010), Lee KM (2012)	3
USP4	3	HUWE1	22	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang X (2011), Zhang X (2011), Zhang X (2011)	3
USP4	3	PCNA	0	enzymatic study	Clerici M (2014)	1
DDB1	6	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji Q (2014), Ji Q (2014), Romani B (2016)	3
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
MAPK6	1	PSMD14	3	affinity chromatography technology	Rodriguez J (2016)	1
HUWE1	22	ZBTB17	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Lee CK (2015), Lee CK (2015)	4
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
FBXW11	2	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Coyaud E (2015)	3
HSPB1	2	ZBTB17	2	two hybrid	Katsogiannou M (2014)	1
MAPK6	1	CDC6	0	affinity chromatography technology	Rodriguez J (2016)	1
HUWE1	22	HUWE1	22	enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study	Pandya RK (2010), Chen D (2005), Lee CK (2015), Zhang W (2016), Sander B (2017), Sander B (2017), Sander B (2017), Sander B (2017), Byrne R (2017)	9
PSMB7	1	PSMD14	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Wang X (2007)	2
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
HUWE1	22	MYOD1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Noy T (2012), Noy T (2012), Noy T (2012)	3
UBE2D3	1	PCNA	0	enzymatic study	Hibbert RG (2012)	1
FAF2	4	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
MCL1	1	TP53	0	unspecified method, affinity chromatography technology	Lee MS (2014), Zhang X (2016)	2
USP7	14	MYC	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Tavana O (2016), Tavana O (2016), Tavana O (2016), Tavana O (2016)	4
SHOC2	4	HUWE1	22	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jang ER (2014), Jang ER (2014), Jang ER (2014), Jang ER (2014), Jang ER (2015), Jang ER (2015)	6
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
PCNA	0	MCL1	1	affinity chromatography technology, pull down, two hybrid	Fujise K (2000), Fujise K (2000), Fujise K (2000)	3
CDKN2A	1	HSPA4	3	pull down	Souza-Rodrigues E (2007)	1
USP7	14	HIST3H2BB	0	enzymatic study	van der Knaap JA (2005)	1
HUWE1	22	HSPB1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Thompson JW (2014), Katsogiannou M (2014), Katsogiannou M (2014)	3
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
KLF4	2	HDAC2	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Meng F (2009), Meng F (2009), Noti JD (2005), Yu K (2011), Yu K (2011)	5
HUWE1	22	HDAC2	1	affinity chromatography technology, enzymatic study	Zhang J (2011), Zhang J (2011)	2
PSMB7	1	UBE2D1	0	biochemical	Havugimana PC (2012)	1
CUL4B	8	PCNA	0	affinity chromatography technology	Banks D (2006)	1
MAPK6	1	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
CTNNB1	30	UBE2D1	0	pull down	Saha A (2008)	1
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
BRCA1	7	PSMD14	3	affinity chromatography technology	Ertych N (2016)	1
CUL4B	8	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Nathan JA (2013)	2
UBC	7	HSPB1	2	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
MYC	2	PIAS2	2	affinity chromatography technology	Zhang Y (2007)	1
UBE2D1	0	USP9X	15	biochemical, biochemical	Havugimana PC (2012), You J (2001)	2
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
DDB1	6	CTNNB1	30	affinity chromatography technology	Kawajiri K (2009)	1
HUWE1	22	SSR1	1	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Hein MY (2015)	2
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
MAPK6	1	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
UBL4A	0	HSPA4	3	affinity chromatography technology	Xu Y (2012)	1
UBL4A	0	HSPB1	2	affinity chromatography technology	Xu Y (2012)	1
HUWE1	22	MCL1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Warr MR (2005), Warr MR (2005), Warr MR (2011), Warr MR (2011), Pandya RK (2010), Gomez-Bougie P (2011), Gomez-Bougie P (2011), Schwickart M (2010), Schwickart M (2010), Pervin S (2011), Bewley MA (2011), Bewley MA (2011), Rolfo A (2012), Rolfo A (2012), Stankiewicz AR (2009), Zhong Q (2005), Zhong Q (2005), Liao M (2011), Thompson JW (2014), Park SH (2016), Sander B (2017)	21
MDM2	2	UBE2L3	1	pull down, pull down	Hampe C (2006), Yamauchi T (2014)	2
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
MAPK6	1	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
UBL4A	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Xu Y (2012)	2
MYC	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSPA4	3	DDIT4	0	two hybrid	Lim J (2006)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBL4A	0	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Thompson JW (2014)	2
VCP	6	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Thompson JW (2014)	2
CDC6	0	ATM	9	pull down	Yoshida K (2010)	1
HUWE1	22	UBE2D2	0	pull down, pull down, pull down, pull down	Warr MR (2005), Kristariyanto YA (2015), Li L (2015), Zhang W (2016)	4
HUWE1	22	PIAS2	2	enzymatic study, affinity chromatography technology	Yang Y (2010), Yang Y (2010)	2
NR1D1	1	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Yin L (2010), Yin L (2010)	2
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
MAPK6	1	UBL4A	0	affinity chromatography technology	Rodriguez J (2016)	1
BRCA1	7	MYH9	19	affinity chromatography technology	Ertych N (2016)	1
FAF2	4	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Thompson JW (2014)	2
MYC	2	HSPB1	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
HUWE1	22	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Zhang J (2011), Adhikary S (2005), Schwarz SE (1998), Chen D (2005), Kristariyanto YA (2015), Lee CK (2015), Zhao X (2008)	7
ATM	9	MDM2	2	enzymatic study, enzymatic study	Wang Z (2012), Luo H (2016)	2
FAF2	4	UBE2D1	0	pull down	Phan VT (2010)	1
FBXW11	2	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Low TY (2014), Low TY (2014)	2
MAPK6	1	UBE2L3	1	two hybrid	Vinayagam A (2011)	1
FBXW11	2	MDM2	2	affinity chromatography technology	Inuzuka H (2010)	1
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
HUWE1	22	PPP5C	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Kurokawa M (2013), Kurokawa M (2013), Kurokawa M (2013)	3
MAPK6	1	HSPB1	2	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
HUWE1	22	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gomez-Bougie P (2011), Schwickart M (2010), Schwickart M (2010)	3
UBC	7	MYCN	2	affinity chromatography technology	Yu F (2014)	1
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
BRCA1	7	OGT	4	affinity chromatography technology	Ertych N (2016)	1
MCL1	1	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Gomez-Bougie P (2011), Gomez-Bougie P (2011), Schwickart M (2010), Schwickart M (2010), Schwickart M (2010), Zhang C (2011), Trivigno D (2012), Peddaboina C (2012)	8
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
UBL4A	0	OGT	4	affinity chromatography technology	Xu Y (2012)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
HUWE1	22	DDB1	6	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Yi J (2015)	2
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
HDAC2	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Johnson CA (2002), Johnson CA (2002)	2
BRCA1	7	HSPA4	3	affinity chromatography technology	Ertych N (2016)	1
CDC6	0	HUWE1	22	two hybrid, pull down, affinity chromatography technology	Hall JR (2007), Hall JR (2007), Hall JR (2007)	3
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
HUWE1	22	CUL4B	8	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yi J (2015), Yi J (2015), Yi J (2015)	3
HUWE1	22	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Thompson JW (2014), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017)	4
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
MAPK6	1	FAF2	4	affinity chromatography technology	Rodriguez J (2016)	1
CUL4B	8	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	HSPB1	2	affinity chromatography technology	Yu CC (2013)	1
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
HUWE1	22	MYH9	19	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Hein MY (2015)	2
MYCN	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology	Amente S (2007), Amente S (2007)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
VCP	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Okoro DR (2013)	2
TXNDC9	0	HUWE1	22	biochemical, affinity chromatography technology	Kristensen AR (2012), Thompson JW (2014)	2
MYC	2	SSR1	1	affinity chromatography technology	Agrawal P (2010)	1
BRCA1	7	UBE2L3	1	pull down, two hybrid, x-ray crystallography, pull down	Brzovic PS (2003), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
UBE2L3	1	HSPA4	3	enzymatic study	Pridgeon JW (2004)	1
MYC	2	DDB1	6	affinity chromatography technology	Choi SH (2010)	1
PCNA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Groehler AL (2010), Banks D (2006)	2
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
MYCN	2	HUWE1	22	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Zhao X (2008), Zhao X (2008), Zhao X (2008), Zhao X (2008), Zhao X (2008)	5
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3
CDKN2A	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3
MYCN	2	ZBTB17	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Akter J (2011), Akter J (2011), Iraci N (2011), Iraci N (2011)	4
CDKN2A	1	ZBTB17	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Miao L (2010), Miao L (2010), Miao L (2010)	3
PCNA	0	CDC6	0	two hybrid	Saha P (1998)	1
TP53	0	MYH9	19	affinity chromatography technology	Horikawa I (2014)	1