PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
WT1	1	THAP1	1	two hybrid	Daakour S (2016)	1
HIF1AN	0	SERF2	0	affinity chromatography technology	Rodriguez J (2016)	1
PTPN11	20	SERF2	0	two hybrid	Daakour S (2016)	1
SERF2	0	BOLL	0	two hybrid	Rolland T (2014)	1
DAB1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DAB1	1	SERF2	0	two hybrid	Rolland T (2014)	1
SERF2	0	THAP1	1	two hybrid	Rolland T (2014)	1
SP4	4	SERF2	0	two hybrid	Rolland T (2014)	1
SERF2	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
SERF2	0	PSME3	0	two hybrid	Rual JF (2005)	1
UPF2	2	SERF2	0	two hybrid	Lehner B (2004)	1
NELFCD	3	SERF2	0	two hybrid	Stelzl U (2005)	1
PSMA3	1	PSME3	0	biochemical	Wan C (2015)	1
SERF2	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
QKI	1	THAP1	1	two hybrid	Lim J (2006)	1
GC	0	SERF2	0	two hybrid	Stelzl U (2005)	1
PSMA3	1	SERF2	0	two hybrid	Rolland T (2014)	1
QKI	1	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
SERF2	0	RBPMS	0	two hybrid	Rual JF (2005)	1
RBPMS	0	BOLL	0	two hybrid	Rolland T (2014)	1
QKI	1	SERF2	0	two hybrid	Lim J (2006)	1
WT1	1	KRTAP10-3	1	two hybrid, two hybrid	Rolland T (2014), Daakour S (2016)	2
WT1	1	SERF2	0	two hybrid	Daakour S (2016)	1
SERF2	0	CHD3	19	two hybrid	Stelzl U (2005)	1
MDFI	1	SERF2	0	two hybrid	Rual JF (2005)	1