PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	YWHAG	5	affinity chromatography technology	Kirli K (2015)	1
CEP290	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
YWHAG	5	MPHOSPH9	1	two hybrid	Bandyopadhyay S (2010)	1
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP89	2	CCDC14	2	bioid	Gupta GD (2015)	1
SPICE1	2	RPGRIP1L	2	bioid	Gupta GD (2015)	1
DEUP1	0	MPHOSPH9	1	bioid	Firat-Karalar EN (2014)	1
ODF2	1	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP120	5	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	KIAA0753	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
KIAA0753	1	POC5	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
XPO1	8	CNTROB	6	affinity chromatography technology	Kirli K (2015)	1
CDC14A	4	CEP135	2	bioid	St-Denis N (2016)	1
LATS2	1	CENPJ	6	bioid	Couzens AL (2013)	1
CEP162	3	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CEP104	4	CEP162	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
RPGRIP1L	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP290	5	CEP97	0	affinity chromatography technology, affinity chromatography technology, bioid	Li J (2012), Gupta GD (2015), Gupta GD (2015)	3
CNTRL	5	CCDC14	2	bioid	Gupta GD (2015)	1
CDC14A	4	CEP290	5	bioid	St-Denis N (2016)	1
CCDC14	2	MPHOSPH9	1	bioid	Firat-Karalar EN (2014)	1
CEP104	4	CEP290	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP89	2	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
POC5	5	MED4	2	bioid	Gupta GD (2015)	1
CNTROB	6	MPHOSPH9	1	bioid	Gupta GD (2015)	1
MED4	2	CCDC14	2	bioid	Lambert JP (2015)	1
DEUP1	0	OFD1	3	bioid	Firat-Karalar EN (2014)	1
RPGRIP1L	2	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	MPHOSPH9	1	bioid	Lambert JP (2015)	1
CENPJ	6	MPHOSPH9	1	bioid	Gupta GD (2015)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
CEP120	5	CNTROB	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
YWHAZ	1	MPHOSPH9	1	two hybrid	Bandyopadhyay S (2010)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CEP97	0	MPHOSPH9	1	bioid	Gupta GD (2015)	1
RPGRIP1L	2	CEP97	0	bioid	Gupta GD (2015)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
CEP290	5	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP135	2	CEP97	0	bioid	Gupta GD (2015)	1
PCM1	5	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
NINL	1	SVIL	9	bioid	Gupta GD (2015)	1
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
SPICE1	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP162	3	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP63	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP104	4	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CNTRL	5	KIAA0753	1	bioid	Gupta GD (2015)	1
CCDC14	2	CNTROB	6	bioid	Firat-Karalar EN (2014)	1
CEP162	3	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CCDC14	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CENPJ	6	CEP97	0	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
DEUP1	0	CEP128	1	bioid	Firat-Karalar EN (2014)	1
CDC14A	4	MPHOSPH9	1	bioid	St-Denis N (2016)	1
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
PCM1	5	RPGRIP1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP128	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
LATS2	1	NINL	1	bioid	Couzens AL (2013)	1
PCM1	5	CEP97	0	bioid	Gupta GD (2015)	1
PCM1	5	KIAA0753	1	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
YWHAZ	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
CEP89	2	YWHAG	5	bioid	Gupta GD (2015)	1
MED4	2	CNTROB	6	bioid	Lambert JP (2015)	1
CEP128	1	CEP290	5	bioid	Gupta GD (2015)	1
EGLN3	0	MPHOSPH9	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CEP97	0	affinity chromatography technology	Rodriguez J (2016)	1
CDC14A	4	ODF2	1	bioid	St-Denis N (2016)	1
SVIL	9	ODF2	1	two hybrid	Smith TC (2010)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
CEP135	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
DEUP1	0	CEP63	2	bioid	Firat-Karalar EN (2014)	1
PCM1	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
LATS2	1	SPICE1	2	bioid	Couzens AL (2013)	1
CEP120	5	CEP97	0	bioid	Gupta GD (2015)	1
LATS2	1	OFD1	3	bioid	Couzens AL (2013)	1
NINL	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP162	3	CEP120	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP89	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
SPICE1	2	KIAA0753	1	bioid	Gupta GD (2015)	1
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
USP11	3	MPHOSPH9	1	affinity chromatography technology	Sowa ME (2009)	1
CNTRL	5	RPGRIP1L	2	bioid	Gupta GD (2015)	1
XPO1	8	POC5	5	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	CENPJ	6	affinity chromatography technology	Rodriguez J (2016)	1
CEP135	2	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
POC5	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP290	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CDC14A	4	CNTROB	6	bioid	St-Denis N (2016)	1
POC5	5	OFD1	3	bioid	Gupta GD (2015)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
PCM1	5	CCDC14	2	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
LATS2	1	MPHOSPH9	1	bioid	Couzens AL (2013)	1
CEP162	3	KIAA0753	1	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
YWHAZ	1	CENPJ	6	two hybrid	Bandyopadhyay S (2010)	1
LATS2	1	CEP89	2	bioid	Couzens AL (2013)	1
ODF2	1	CEP97	0	bioid	Gupta GD (2015)	1
ODF2	1	MPHOSPH9	1	bioid	Gupta GD (2015)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
CNTRL	5	PCM1	5	bioid	Gupta GD (2015)	1
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MED4	2	OFD1	3	bioid	Lambert JP (2015)	1
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	OFD1	3	bioid	Gupta GD (2015)	1
XPO1	8	CEP97	0	affinity chromatography technology	Kirli K (2015)	1
PCM1	5	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CNTRL	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CENPJ	6	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
POC5	5	PCM1	5	bioid	Gupta GD (2015)	1
CDC14A	4	POC5	5	bioid	St-Denis N (2016)	1
NINL	1	CENPJ	6	bioid	Gupta GD (2015)	1
CDC14A	4	SPICE1	2	bioid	St-Denis N (2016)	1
NINL	1	OFD1	3	bioid	Gupta GD (2015)	1
ODF2	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP290	5	PCM1	5	bioid	Gupta GD (2015)	1
CEP120	5	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP63	2	KIAA0753	1	bioid, bioid, affinity chromatography technology, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	4
XPO1	8	MPHOSPH9	1	affinity chromatography technology	Kirli K (2015)	1
CEP120	5	OFD1	3	bioid	Gupta GD (2015)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
LATS2	1	YWHAG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe	Okada N (2011), Okada N (2011), Okada N (2011), Ivanov AA (2017)	4
KIAA0753	1	OFD1	3	bioid, bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	4
CENPJ	6	CEP120	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
PCM1	5	CENPJ	6	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
NINL	1	CEP89	2	bioid	Gupta GD (2015)	1
MED4	2	CEP290	5	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP128	1	CEP97	0	bioid	Gupta GD (2015)	1
CNTROB	6	OFD1	3	bioid	Gupta GD (2015)	1
CNTRL	5	ODF2	1	bioid	Gupta GD (2015)	1
CEP63	2	OFD1	3	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
CEP162	3	CEP89	2	bioid	Gupta GD (2015)	1
KIAA0753	1	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
YWHAZ	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
CEP89	2	OFD1	3	bioid	Gupta GD (2015)	1
EGLN3	0	PCM1	5	affinity chromatography technology	Rodriguez J (2016)	1
POC5	5	CEP128	1	bioid	Gupta GD (2015)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	MPHOSPH9	1	bioid	Firat-Karalar EN (2014)	1
OFD1	3	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP63	2	MED4	2	bioid	Gupta GD (2015)	1
CNTRL	5	OFD1	3	bioid	Gupta GD (2015)	1
YWHAG	5	CENPJ	6	two hybrid, bioid	Bandyopadhyay S (2010), Gupta GD (2015)	2
NINL	1	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP128	1	CCDC14	2	bioid	Gupta GD (2015)	1
LATS2	1	PCM1	5	bioid	Couzens AL (2013)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
YWHAZ	1	PCM1	5	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP290	5	KIAA0753	1	bioid	Gupta GD (2015)	1
CNTRL	5	MED4	2	bioid	Gupta GD (2015)	1
XPO1	8	SPICE1	2	affinity chromatography technology	Kirli K (2015)	1
CEP135	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CEP63	2	CCDC14	2	two hybrid, bioid, bioid, affinity chromatography technology, bioid	Camargo LM (2007), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	5
POC5	5	CCDC14	2	bioid	Gupta GD (2015)	1
CEP120	5	SPICE1	2	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	3
KIAA0753	1	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP104	4	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP162	3	CEP97	0	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CNTRL	5	CEP89	2	bioid	Gupta GD (2015)	1
MED4	2	CEP162	3	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP89	2	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP89	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
NINL	1	CCDC14	2	bioid	Gupta GD (2015)	1
CDC14A	4	CEP162	3	bioid	St-Denis N (2016)	1
CCDC14	2	OFD1	3	bioid, bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015), Hein MY (2015)	4
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
NINL	1	CEP97	0	bioid	Gupta GD (2015)	1
LATS2	1	CNTROB	6	bioid	Couzens AL (2013)	1
SVIL	9	MPHOSPH9	1	two hybrid	Smith TC (2010)	1
CEP97	0	CEP104	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	SPICE1	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CEP135	2	CEP120	5	bioid	Gupta GD (2015)	1
NINL	1	KIAA0753	1	bioid	Gupta GD (2015)	1
SPICE1	2	CENPJ	6	bioid	Gupta GD (2015)	1
CNTRL	5	CEP162	3	bioid	Gupta GD (2015)	1
CEP104	4	PCM1	5	bioid	Gupta GD (2015)	1
MED4	2	ODF2	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2