PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
SRC	2	BCAR1	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Burnham MR (1999), Burnham MR (1999), Wei L (2002), Hsia DA (2003), Kovacic-Milivojevic B (2001), Donaldson JC (2000), Angers-Loustau A (1999), Cabodi S (2004), Modzelewska K (2006), Sawada Y (2006), Riggins RB (2006), Riggins RB (2006)	12
NUP155	2	EFS	2	two hybrid	Rolland T (2014)	1
BCAR1	6	PTPN12	2	affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, bioid	Lin Y (2003), Garton AJ (1997), Garton AJ (1997), Garton AJ (1997), Cote JF (1998), Cote JF (1998), Garton AJ (1996), Garton AJ (1996), St-Denis N (2016)	9
EFS	2	OSTF1	2	two hybrid	Rolland T (2014)	1
SORBS3	5	EFS	2	two hybrid	Rual JF (2005)	1
EFS	2	CRK	0	far western blotting	Alexandropoulos K (1996)	1
ABI2	4	EFS	2	two hybrid	Rolland T (2014)	1
EFS	2	SRC	2	unspecified method, unspecified method, affinity chromatography technology	Alexandropoulos K (1996), Alexandropoulos K (1996), Alexandropoulos K (1996)	3
SH2D3C	2	EFS	2	two hybrid	Rual JF (2005)	1
SH2D3C	2	BCAR1	6	affinity chromatography technology	Sakakibara A (2000)	1
OSTF1	2	APP	1	pull down	Olah J (2011)	1
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
FYN	1	EFS	2	pull down, enzymatic study, two hybrid	Donlin LT (2002), Donlin LT (2002), Rolland T (2014)	3
OSTF1	2	SRC	2	affinity chromatography technology	Szymkiewicz I (2004)	1
SORBS2	2	PTPN12	2	affinity chromatography technology, pull down, affinity chromatography technology	Taieb D (2008), Taieb D (2008), Taieb D (2008)	3
EFS	2	ZNF417	2	two hybrid	Rolland T (2014)	1
UBC	7	EFS	2	pull down	Nathan JA (2013)	1
EFS	2	TRAPPC6A	0	two hybrid	Rual JF (2005)	1
NPAS2	0	EFS	2	two hybrid	Corominas R (2014)	1
BCAR1	6	FYN	1	two hybrid, affinity chromatography technology, pull down	Donaldson JC (2000), Manie SN (1997), Manie SN (1997)	3
CRK	0	UBC	7	affinity chromatography technology	Brehme M (2009)	1
BCAR1	6	EFS	2	two hybrid	Stelzl U (2005)	1
LYST	8	EFS	2	two hybrid	Tchernev VT (2002)	1
SORBS2	2	EFS	2	two hybrid	Rolland T (2014)	1
BCAR1	6	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Zhou B (2004), Di Stefano P (2004), Hsia DA (2003), Hsia DA (2003), Gu J (2001), Garton AJ (1999), Angers-Loustau A (1999), Qiu W (1998), Blaukat A (1999), Wang JF (2000), Holcomb M (2006), Wu Y (2005), Cho SY (2000), Modzelewska K (2006), Modzelewska K (2006), Brehme M (2009), Cho SY (2002), Cho SY (2002), Mielenz D (2001), Peterson ME (2008), Liu BA (2012), Larsson H (1999)	22
BLK	4	EFS	2	two hybrid	Rolland T (2014)	1
EFS	2	PTPN12	2	pull down	Cote JF (1998)	1
EFS	2	TSSK1B	0	two hybrid	Rolland T (2014)	1
PTPN12	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NLGN3	3	EFS	2	two hybrid	Shen C (2015)	1
EFS	2	APP	1	pull down	Olah J (2011)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2