PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VAPA	1	RTN4	4	biochemical	Wan C (2015)	1
FGFR1	2	RTN3	2	two hybrid	Hu Y (2004)	1
TRIM25	5	ATP1B3	0	affinity chromatography technology	Choudhury NR (2017)	1
RTN4	4	ATL3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
HNRNPL	3	COL4A3BP	18	affinity chromatography technology	Fei T (2017)	1
COL4A3BP	18	RTN4	4	two hybrid	Rual JF (2005)	1
COL4A3BP	18	RTN3	2	two hybrid	Rual JF (2005)	1
RTN4	4	SPOP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LMNA	2	RTN3	2	two hybrid	Dittmer TA (2014)	1
TERF1	1	RTN3	2	two hybrid	Lee OH (2011)	1
RTN3	2	RTN4	4	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
VAPA	1	RTN3	2	biochemical	Wan C (2015)	1
ATP1B3	0	RTN4	4	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
LMNA	2	PTPN9	2	two hybrid	Dittmer TA (2014)	1
ATP1B3	0	TCTN2	2	affinity chromatography technology	Huttlin EL (2015)	1
RTN3	2	FAM160A2	3	two hybrid	Rual JF (2005)	1
RTN4	4	PLEKHF2	1	two hybrid	Rual JF (2005)	1
LMNA	2	RTN4	4	two hybrid	Dittmer TA (2014)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	ATL3	0	affinity chromatography technology	Choudhury NR (2017)	1
TERF1	1	RTN4	4	two hybrid	Lee OH (2011)	1
TCTN2	2	RTN3	2	bioid	Gupta GD (2015)	1
SNX1	2	RTN3	2	two hybrid	Rolland T (2014)	1
FXR2	2	SNX1	2	affinity chromatography technology	Huttlin EL (2017)	1
RTN3	2	RTN3	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UGCG	0	RTN3	2	two hybrid	Di Sano F (2003)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
TCTN3	2	RTN3	2	bioid	Gupta GD (2015)	1
RAB33A	0	RTN3	2	two hybrid	Rual JF (2005)	1
TRIM25	5	RTN3	2	affinity chromatography technology	Choudhury NR (2017)	1
RTN3	2	ZNF391	1	two hybrid	Rolland T (2014)	1
SNX1	2	RTN4	4	two hybrid, biochemical	Rolland T (2014), Wan C (2015)	2
RTN3	2	PLEKHF2	1	two hybrid	Rual JF (2005)	1
FXR2	2	RTN4	4	two hybrid	Rual JF (2005)	1
PTPN9	2	RTN3	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RTN3	2	CDIPT	0	two hybrid	Rolland T (2014)	1
TCTN2	2	VAPA	1	bioid	Gupta GD (2015)	1
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
HNRNPL	3	RTN3	2	affinity chromatography technology	Fei T (2017)	1
RAB33A	0	RTN4	4	two hybrid	Rual JF (2005)	1
TERF1	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
ATP1B3	0	RTN3	2	biochemical	Wan C (2015)	1
XPO1	8	RTN3	2	affinity chromatography technology	Kirli K (2015)	1
GLP1R	4	RTN3	2	protein complementation assay	Dai FF (2015)	1
TRIM25	5	RTN4	4	affinity chromatography technology	Choudhury NR (2017)	1
RTN4	4	BCL2	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tagami S (2000), Tagami S (2000), Tagami S (2000), Wan Q (2007)	4
LMNA	2	HNRNPL	3	affinity chromatography technology	Depreux FF (2015)	1
FXR2	2	RTN3	2	two hybrid	Rual JF (2005)	1
SPOP	1	RTN3	2	two hybrid	Rual JF (2005)	1
ATL3	0	RTN3	2	affinity chromatography technology	Hein MY (2015)	1
RTN3	2	PPP2R3C	1	two hybrid	Rolland T (2014)	1
TRIM25	5	LMNA	2	affinity chromatography technology	Choudhury NR (2017)	1
PRTFDC1	0	RTN3	2	biochemical	Havugimana PC (2012)	1
GLP1R	4	RTN4	4	protein complementation assay	Dai FF (2015)	1
BCL2	0	RTN3	2	affinity chromatography technology	Wan Q (2007)	1
TRIM25	5	UGCG	0	affinity chromatography technology	Choudhury NR (2017)	1