PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PML	7	CCNT1	3	affinity chromatography technology, pull down, fluorescent resonance energy transfe, imaging technique	Marcello A (2003), Marcello A (2003), Marcello A (2003), Forlani G (2017)	4
TRIM22	2	TRIM22	2	pull down	Li X (2007)	1
TRIM22	2	EIF4E	1	affinity chromatography technology, affinity chromatography technology	Petersson J (2012), Petersson J (2012)	2
TRIM22	2	CHUK	5	affinity chromatography technology	Qiu H (2014)	1
TRIM22	2	CCNT1	3	imaging technique	Forlani G (2017)	1
CHUK	5	TAB2	5	affinity chromatography technology	Kishida S (2005)	1
RERE	9	TRIM22	2	two hybrid	Lim J (2006)	1
TRIM22	2	TAB2	5	affinity chromatography technology, affinity chromatography technology	Qiu H (2013), Qiu H (2013)	2
CASK	18	TRIM22	2	two hybrid	Wang J (2011)	1
TRIM22	2	ZZZ3	2	two hybrid	Ravasi T (2010)	1
TAF7	0	TRIM22	2	two hybrid	Ravasi T (2010)	1
CIITA	4	CCNT1	3	imaging technique	Forlani G (2017)	1
CREB1	1	TRIM22	2	two hybrid	Ravasi T (2010)	1
CIC	9	TRIM22	2	two hybrid	Lim J (2006)	1
USP7	14	TRIM22	2	two hybrid	Lim J (2006)	1
LGALS3	0	TRIM22	2	pull down	Chauhan S (2016)	1
TRIM22	2	CIITA	4	affinity chromatography technology, imaging technique	Forlani G (2017), Forlani G (2017)	2
CCNT1	3	TAF7	0	affinity chromatography technology	Gegonne A (2008)	1
TRIM22	2	PML	7	imaging technique	Forlani G (2017)	1
PML	7	EIF4E	1	pull down, pull down, imaging technique, pull down	Cohen N (2001), Kentsis A (2001), Topisirovic I (2002), Kentsis A (2002)	4
CIITA	4	PML	7	imaging technique	Forlani G (2017)	1
USP7	14	PML	7	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Sivachandran N (2010), Sarkari F (2011), Sarkari F (2011), Hein MY (2015)	4
LGALS8	4	TRIM22	2	pull down	Chauhan S (2016)	1