PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
CREBBP	29	CITED2	0	affinity chromatography technology	Bhattacharya S (1999)	1
EGLN3	0	CITED2	0	affinity chromatography technology	Rodriguez J (2016)	1
TBP	0	CREBBP	29	affinity chromatography technology	Dallas PB (1997)	1
SMAD2	5	CITED2	0	affinity chromatography technology	Chou YT (2006)	1
CITED2	0	TBP	0	pull down	Glenn DJ (1999)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
CITED2	0	TFAP2B	2	pull down	Braganca J (2002)	1
EP300	36	CITED2	0	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, protein complementation assay	Bhattacharya S (1999), Braganca J (2003), Braganca J (2003), Braganca J (2002), Bhattacharya S (1999), Glenn DJ (1999), Matt T (2004), Freedman SJ (2003), Hein MY (2015), Machado-Oliveira G (2015)	10
CITED2	0	FBXL5	3	two hybrid, pull down, protein complementation assay	Machado-Oliveira G (2015), Machado-Oliveira G (2015), Machado-Oliveira G (2015)	3
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
EP300	36	TFAP2A	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Braganca J (2003), Braganca J (2003), Shi D (2015)	3
TBP	0	EP300	36	affinity chromatography technology	Dallas PB (1997)	1
LHX3	0	CITED2	0	two hybrid	Glenn DJ (1999)	1
LHX2	0	CITED2	0	two hybrid, pull down, affinity chromatography technology	Glenn DJ (1999), Glenn DJ (1999), Glenn DJ (1999)	3
CITED2	0	TFAP2C	4	two hybrid, pull down	Braganca J (2003), Braganca J (2002)	2
EGLN3	0	MAPK1	1	two hybrid	Wang J (2011)	1
TFAP2A	1	TFAP2C	4	affinity chromatography technology	Thewes V (2010)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CITED2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
ELAVL1	0	TFAP2A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
CITED2	0	TFAP2A	1	two hybrid, far western blotting, pull down	Braganca J (2003), Braganca J (2003), Braganca J (2002)	3
SMAD3	1	CITED2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Chou YT (2006), Chou YT (2006), Chou YT (2006), Chou YT (2006)	4
ELAVL1	0	TBP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK1	1	CITED2	0	enzymatic study	Chen CM (2012)	1
TFAP2B	2	CREBBP	29	affinity chromatography technology	Guo W (2014)	1
TFAP2A	1	TFAP2B	2	affinity chromatography technology	Keyel PA (2008)	1
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
EP300	36	FBXL5	3	two hybrid	Wang J (2011)	1
MAPK1	1	SMAD3	1	enzymatic study, affinity chromatography technology	Alarcon C (2009), Brown KA (2008)	2
ELAVL1	0	TFAP2C	4	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1