PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IRF9	0	STAT2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Horvath CM (1996), Horvath CM (1996), Martinez-Moczygemba M (1997), Martinez-Moczygemba M (1997), Li S (2011), Huttlin EL (2017)	6
HOXC9	0	IRF9	0	two hybrid	Ravasi T (2010)	1
IRF9	0	ANKHD1-EIF4EBP3	0	affinity chromatography technology	Huttlin EL (2017)	1
NR2E3	2	IRF9	0	two hybrid	Ravasi T (2010)	1
IFNAR2	1	IRF9	0	affinity chromatography technology	Tang X (2007)	1
STAT1	1	IRF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Chatterjee-Kishore M (2000), Chatterjee-Kishore M (2000), Remoli AL (2006)	3
IRF9	0	TLX3	1	two hybrid	Ravasi T (2010)	1
IRF9	0	S100A13	0	two hybrid	Wang J (2011)	1
IRF9	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
TLX2	0	IRF9	0	two hybrid	Ravasi T (2010)	1
CREBBP	29	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, genetic interference, genetic interference, genetic interference, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang HD (2004), Zhong H (2002), Zhong H (2002), Parry GC (1997), Parry GC (1997), Parry GC (1997), Aarnisalo P (1998), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Liu GH (2008), Vanden Berghe W (1999), Naeaer AM (1999), Merika M (1998), Park J (2007), Verma UN (2004), Verma UN (2004), Verma UN (2004), Johnson J (2007), Aksoy E (2007), Azran I (2005), Silverman ES (1998), Huang WC (2007), Huang WC (2007), Aarnisalo P (1998), Kim HJ (1999), Hsu DS (2014), Chen Y (2015), Huang SM (2002)	30
NFKB1	2	IRF9	0	pull down	Drew PD (1995)	1
FOXL1	0	ARID3B	4	affinity chromatography technology	Li X (2015)	1
IRF9	0	DMRTC2	0	two hybrid	Ravasi T (2010)	1
IFNAR2	1	STAT2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (1997), Nguyen VP (2002), Nguyen VP (2002), Tang X (2007)	4
TOP1	1	ELAVL1	0	affinity chromatography technology	Czubaty A (2005)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
ARIH1	3	HOXC9	0	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	IRF1	0	pull down	Merika M (1998)	1
TLX2	0	POU2F1	5	two hybrid	Ravasi T (2010)	1
IRF9	0	STAT1	1	two hybrid, pull down	Horvath CM (1996), Horvath CM (1996)	2
POU2F1	5	IRF9	0	two hybrid	Ravasi T (2010)	1
HOXC9	0	POU2F1	5	two hybrid	Ravasi T (2010)	1
IFNAR2	1	CREBBP	29	affinity chromatography technology	Tang X (2007)	1
IRF9	0	ANKHD1	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	IRF9	0	affinity chromatography technology	Abdelmohsen K (2009)	1
IFNAR2	1	STAT1	1	pull down, pull down	Li X (1997), Usacheva A (2001)	2
IRF9	0	ANKRD17	10	affinity chromatography technology	Huttlin EL (2017)	1
RELA	1	IRF9	0	pull down	Drew PD (1995)	1
ELAVL1	0	STAT2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DNMT3A	17	IRF9	0	affinity chromatography technology	Hervouet E (2009)	1
IRF1	0	IRF9	0	two hybrid, two hybrid	Ravasi T (2010), Childs KS (2003)	2
TOP1	1	IRF9	0	unspecified method	Trzcinska AM (2002)	1
FOXL1	0	IRF9	0	affinity chromatography technology	Li X (2015)	1
IRF9	0	UBE2R2	2	affinity chromatography technology	Huttlin EL (2017)	1
IRF9	0	DACH2	0	two hybrid	Ravasi T (2010)	1
IRF9	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
IRF9	0	MYO1F	3	two hybrid	Wang J (2011)	1
CREBBP	29	STAT2	2	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Bhattacharya S (1996), Bhattacharya S (1996), Bhattacharya S (1996), Bhattacharya S (1996), Huttlin EL (2017), Lindstroem I (2017)	6
CREBBP	29	STAT1	1	pull down, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhang JJ (1996), Zhang JJ (1996), Horvai AE (1997), Horvai AE (1997), Ma Z (2005), Vaelineva T (2005), Strassheim D (2009), Kraemer OH (2006), Kraemer OH (2006), Jansma AL (2014), Chen Y (2015)	11
CREBBP	29	IRF9	0	affinity chromatography technology	Tang X (2007)	1
STAT1	1	STAT2	2	biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (1996), Dumler I (1999), Dumler I (1999), Dumler I (1999), Fagerlund R (2002), Tang X (2007), Gupta S (1999), Liu B (1998), Huttlin EL (2017)	9
STAT1	1	RELA	1	imaging technique	Chen TC (2014)	1
IRF9	0	ARID3B	4	two hybrid	Ravasi T (2010)	1
IRF9	0	VENTX	1	two hybrid	Ravasi T (2010)	1
RELA	1	POU2F1	5	pull down, affinity chromatography technology	van Heel DA (2002), van Heel DA (2002)	2
IRF9	0	IRF2BP1	4	two hybrid	Childs KS (2003)	1
IRF9	0	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1