PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STAT3	0	PIAS3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Wang LH (2001), Okumura F (2010), Yamamoto T (2003), Yamamoto T (2003), Tsuruma R (2008), Liu B (1998), Wang J (2011)	7
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
AR	3	SIAH2	0	affinity chromatography technology, affinity chromatography technology	Qi J (2013), Tan G (2017)	2
SIAH2	0	PIAS3	2	pull down	Depaux A (2007)	1
UBE2I	0	TAB2	5	enzymatic study	Wang X (2014)	1
UBE2I	0	TRIM63	0	two hybrid	McElhinny AS (2002)	1
CBS	0	PIAS3	2	two hybrid	Kabil O (2006)	1
PIAS3	2	TRIM32	2	pull down	Qu J (2007)	1
HIC1	1	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin YM (2013), Lin YM (2013), Lin YM (2013), Lin YM (2013), Hu B (2016), Hu B (2016)	6
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
SATB1	1	UBE2I	0	two hybrid, two hybrid, two hybrid, enzymatic study	Rual JF (2005), Tan JA (2010), Tan JA (2008), Gocke CB (2005)	4
HNRNPK	4	UBE2I	0	two hybrid, affinity chromatography technology	Rual JF (2005), Pelisch F (2012)	2
GFI1	0	PIAS3	2	two hybrid, pull down, affinity chromatography technology	Roedel B (2000), Roedel B (2000), Roedel B (2000)	3
RAC1	7	PIAS3	2	pull down, affinity chromatography technology, enzymatic study	Castillo-Lluva S (2010), Castillo-Lluva S (2010), Castillo-Lluva S (2010)	3
SATB1	1	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Fujii Y (2003), Fujii Y (2003), Fujii Y (2003)	3
TRIM63	0	SUMO2	0	two hybrid, pull down	Dai KS (2001), Dai KS (2001)	2
SPOP	1	UBE2I	0	two hybrid	Zhang P (2017)	1
ELAVL1	0	MITF	3	affinity chromatography technology	Abdelmohsen K (2009)	1
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
SPOP	1	SUMO1	0	two hybrid	Zhang P (2017)	1
CREBBP	29	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, genetic interference, genetic interference, genetic interference, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang HD (2004), Zhong H (2002), Zhong H (2002), Parry GC (1997), Parry GC (1997), Parry GC (1997), Aarnisalo P (1998), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Liu GH (2008), Vanden Berghe W (1999), Naeaer AM (1999), Merika M (1998), Park J (2007), Verma UN (2004), Verma UN (2004), Verma UN (2004), Johnson J (2007), Aksoy E (2007), Azran I (2005), Silverman ES (1998), Huang WC (2007), Huang WC (2007), Aarnisalo P (1998), Kim HJ (1999), Hsu DS (2014), Chen Y (2015), Huang SM (2002)	30
HMGA2	1	PIAS3	2	two hybrid, affinity chromatography technology	Zentner MD (2001), Zentner MD (2001)	2
PIAS3	2	SMAD4	9	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
GFI1	0	RELA	1	affinity chromatography technology, imaging technique	Sharif-Askari E (2010), Sharif-Askari E (2010)	2
CREBBP	29	SREBF2	5	far western blotting, affinity chromatography technology, affinity chromatography technology	Oliner JD (1996), Oliner JD (1996), Nath S (2014)	3
UBE2I	0	TRIM55	2	two hybrid, affinity chromatography technology	McElhinny AS (2002), Lange S (2005)	2
AR	3	PIAS3	2	two hybrid	Kotaja N (2000)	1
ZFHX3	18	PIAS3	2	two hybrid, pull down, affinity chromatography technology	Nojiri S (2004), Nojiri S (2004), Nojiri S (2004)	3
SATB1	1	PIAS3	2	two hybrid, two hybrid	Tan JA (2010), Tan JA (2008)	2
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
SREBF2	5	PIAS3	2	two hybrid	Bandyopadhyay S (2010)	1
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
ZMIZ1	7	PIAS3	2	two hybrid	Peng Y (2010)	1
ELAVL1	0	ZFHX3	18	affinity chromatography technology	Abdelmohsen K (2009)	1
RELA	1	SMAD4	9	two hybrid	Wang J (2011)	1
SPOP	1	PIAS3	2	two hybrid	Zhang P (2017)	1
PIAS3	2	SERPINA10	0	two hybrid	Wang J (2011)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
AR	3	NCOA2	2	two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Song LN (2004), Ishitani K (2003), Wang Q (2004), He B (2003), Bai S (2005)	5
ELAVL1	0	PIAS3	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
SMAD4	9	UBE2I	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Chang CC (2005), Lin X (2003), Colland F (2004), Wang J (2011), Wang J (2011)	6
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
ERBB4	5	TAB2	5	two hybrid, affinity chromatography technology	Sardi SP (2006), Sardi SP (2006)	2
RELA	1	SMAD3	1	two hybrid	Wang J (2011)	1
HNRNPK	4	PIAS3	2	affinity chromatography technology	Lee SW (2012)	1
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
SUMO3	0	PIAS3	2	pull down	Hecker CM (2006)	1
CREM	1	UBE2I	0	two hybrid	Wang J (2011)	1
SREBF2	5	UBE2I	0	affinity chromatography technology, two hybrid	Hirano Y (2003), Bandyopadhyay S (2010)	2
TRIM27	2	PIAS3	2	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
SMAD4	9	PRPF40A	5	two hybrid	Colland F (2004)	1
PIAS3	2	PSMC1	2	two hybrid	Vinayagam A (2011)	1
MITF	3	PIAS3	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Levy C (2002), Levy C (2002), Levy C (2002), Levy C (2002), Murakami H (2005)	5
TRIM55	2	TRIM27	2	two hybrid	Woodsmith J (2012)	1
SATB1	1	SUMO1	0	two hybrid	Tan JA (2008)	1
TAB2	5	PIAS3	2	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
ZMIZ1	7	SATB1	1	affinity chromatography technology	Pinnell N (2015)	1
SKIL	3	PIAS3	2	two hybrid	Colland F (2004)	1
TRIM63	0	PIAS3	2	two hybrid	Witt CC (2008)	1
SMURF2	3	SKIL	3	affinity chromatography technology	Bonni S (2001)	1
PIAS3	2	REX1BD	0	two hybrid	Vinayagam A (2011)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
RELA	1	AR	3	genetic interference, genetic interference	Aarnisalo P (1998), Aarnisalo P (1998)	2
ZMIZ2	1	AR	3	affinity chromatography technology, two hybrid	Huang CY (2005), Huang CY (2005)	2
AR	3	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Liu X (2016), Liu X (2016)	2
RELA	1	PIAS3	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Jang HD (2004), Jang HD (2004), Jang HD (2004), Jang HD (2004), Liu Y (2012)	5
PPP1CA	3	PIAS3	2	two hybrid	Esteves SL (2012)	1
ELAVL1	0	SERBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	HNRNPK	4	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
CBS	0	UBE2I	0	two hybrid, enzymatic study, two hybrid	Kabil O (2006), Kabil O (2006), Rolland T (2014)	3
RAC1	7	STAT3	0	two hybrid, affinity chromatography technology	Simon AR (2000), Simon AR (2000)	2
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
AR	3	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Matsuda T (2001), Ueda T (2002), Yamamoto T (2003), Yamamoto T (2003)	4
CREBBP	29	PIAS3	2	affinity chromatography technology	Long J (2004)	1
AR	3	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Dai Y (2008), Minges JT (2013), Zhong J (2014), Fu M (2000), McClurg UL (2016), Tan G (2017)	6
CREBBP	29	SUMO1	0	x-ray crystallography, pull down	Diehl C (2016), Diehl C (2016)	2
SIAH2	0	STAT3	0	two hybrid	Wang J (2011)	1
EP300	36	PIAS3	2	affinity chromatography technology	Long J (2004)	1
ZFHX3	18	STAT3	0	affinity chromatography technology	Nojiri S (2004)	1
SUMO1	0	PIAS3	2	two hybrid, two hybrid, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006)	3
HNRNPK	4	SMAD3	1	two hybrid	Wang J (2011)	1
ZMIZ1	7	SMAD4	9	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2006), Li X (2006), Li X (2006), Li X (2006)	4
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
CREM	1	PIAS3	2	two hybrid	Wang J (2011)	1
NCOA2	2	PIAS3	2	x-ray crystallography	Jimenez-Lara AM (2002)	1
SUMO1	0	MITF	3	affinity chromatography technology	Murakami H (2005)	1
PIAS3	2	UBA1	1	two hybrid	Vinayagam A (2011)	1
UBE2I	0	BCL11A	14	enzymatic study	Kuwata T (2008)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
ZMIZ1	7	AR	3	affinity chromatography technology, two hybrid	Sharma M (2003), Sharma M (2003)	2
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
GLUL	2	PIAS3	2	two hybrid	Bandyopadhyay S (2010)	1
PIAS3	2	HIC1	1	imaging technique	Sun L (2013)	1
SUMO2	0	PIAS3	2	two hybrid, two hybrid, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006)	3
ELAVL1	0	SUMO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
PRPF40A	5	ZFHX3	18	far western blotting	Bedford MT (1997)	1
EP300	36	SREBF2	5	far western blotting	Oliner JD (1996)	1
SUMO1	0	HNRNPK	4	pull down	Lee SW (2012)	1
EP300	36	MITF	3	affinity chromatography technology	Price ER (1998)	1
PIAS3	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Chandhoke AS (2015), Chandhoke AS (2015)	2
ZMIZ1	7	SMAD3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2006), Li X (2006), Li X (2006), Li X (2006)	4
SIAH1	2	PIAS3	2	pull down	Depaux A (2007)	1
SERBP1	2	PIAS3	2	two hybrid	Lemos TA (2006)	1
PRPF40A	5	PIAS3	2	two hybrid	Colland F (2004)	1
HMGA2	1	RELA	1	pull down	Noro B (2003)	1
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
SMAD4	9	SUMO1	0	affinity chromatography technology	Lee PS (2003)	1
SUMO2	0	HNRNPK	4	pull down	Ouyang J (2009)	1
CREBBP	29	NCOA2	2	pull down, affinity chromatography technology, pull down, two hybrid, pull down	Kindle KB (2005), Torchia J (1997), Voegel JJ (1998), Voegel JJ (1998), Bavner A (2005)	5
CREBBP	29	AR	3	two hybrid, pull down, pull down, genetic interference, affinity chromatography technology, pull down	Kim J (2005), Fronsdal K (1998), Ishitani K (2003), Aarnisalo P (1998), Andersen RJ (2010), Fronsdal K (1998)	6
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
AR	3	SPOP	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	van de Wijngaart DJ (2009), An J (2014), An J (2014), An J (2014), Geng C (2014), Geng C (2014), Geng C (2014)	7
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	SMURF2	3	affinity chromatography technology	Chandhoke AS (2015)	1
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
GEMIN4	2	PIAS3	2	two hybrid	Wang J (2011)	1
PIAS3	2	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
TRIM8	6	PIAS3	2	affinity chromatography technology	Okumura F (2010)	1
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
PRPF40A	5	UBE2I	0	two hybrid	Colland F (2004)	1
SMAD3	1	SREBF2	5	affinity chromatography technology, affinity chromatography technology	Grimsby S (2004), Grimsby S (2004)	2
HABP4	1	UBE2I	0	two hybrid	Nery FC (2006)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
HABP4	1	PIAS3	2	two hybrid	Nery FC (2006)	1
PRPF40A	5	HNRNPK	4	pull down	Ingham RJ (2005)	1
CREBBP	29	STAT3	0	affinity chromatography technology, enzymatic study	Sun Y (2001), Yuan ZL (2005)	2
EP300	36	GLUL	2	enzymatic study, affinity chromatography technology	Nguyen TV (2016), Nguyen TV (2016)	2
STAT3	0	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu Z (2002), Yu Z (2002), Yoshida Y (2004), Yoshida Y (2004), Dhar K (2013)	5
ERBB4	5	PIAS3	2	affinity chromatography technology	Sundvall M (2012)	1
PIAS3	2	BCL11A	14	affinity chromatography technology	Kuwata T (2008)	1
TRIM55	2	PIAS3	2	two hybrid	Witt CC (2008)	1
SIAH1	2	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2I	0	TRIM27	2	two hybrid, affinity chromatography technology	Markson G (2009), Chu Y (2011)	2
STAT3	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima K (1999), Nakashima K (1999), Ray S (2002), Ray S (2002), Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Wang R (2005), Gray MJ (2005), Hou T (2008), Kotla S (2015)	11
SKIL	3	GLUL	2	two hybrid	Colland F (2004)	1
UBE2I	0	HIC1	1	enzymatic study, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2013)	2
NCOA2	2	EP300	36	affinity chromatography technology, two hybrid, enzymatic study	Askew EB (2010), Hong H (1999), Chen H (1999)	3
MITF	3	UBE2I	0	two hybrid, pull down, pull down	Xu W (2000), Xu W (2000), Murakami H (2005)	3
SIAH2	0	UBE2I	0	two hybrid, two hybrid, two hybrid	Depaux A (2007), Hu G (1997), Wang J (2011)	3
GLUL	2	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
EP300	36	SUMO2	0	pull down, enzymatic study	Ullmann R (2012), Ullmann R (2012)	2
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
PIAS3	2	SMAD3	1	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
ELAVL1	0	STAT3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SIAH1	2	STAT3	0	two hybrid, affinity chromatography technology	Wang J (2011), Shin M (2016)	2
ZMIZ2	1	PIAS3	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Peng Y (2010), Peng Y (2010), Peng Y (2010), Peng Y (2010)	4
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
CREBBP	29	CREM	1	pull down	Laurance ME (1997)	1
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
PIAS3	2	SMAD2	5	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
AR	3	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu P (2006), Zhu P (2006), Reineri S (2016)	3