PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBX5	3	POGZ	49	affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Nozawa RS (2010), Nozawa RS (2010), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	7
FAM174A	2	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
SPACA1	1	MAD2L2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAD2L1	0	TRIP13	0	affinity chromatography technology, pull down, affinity chromatography technology	Wang K (2014), Miniowitz-Shemtov S (2015), Sedgwick GG (2016)	3
MAD2L2	0	POLDIP2	1	two hybrid	Tissier A (2010)	1
CBX1	0	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3
CBX1	0	MAD2L2	0	affinity chromatography technology	Hauri S (2016)	1
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
LAMP3	1	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
SFI1	3	MAD2L2	0	two hybrid	Rolland T (2014)	1
TRIP13	0	CDC20	1	pull down, pull down	Miniowitz-Shemtov S (2015), Miniowitz-Shemtov S (2015)	2
NXF1	0	MAD2L2	0	affinity chromatography technology	Castello A (2012)	1
REV1	1	CDC27	2	affinity chromatography technology	Chun AC (2013)	1
RAN	1	NXF1	0	pull down, pull down	Shamsher MK (2002), Katahira J (1999)	2
PRRC2A	10	MAD2L2	0	two hybrid	Lehner B (2004)	1
MAD2L2	0	CHAMP1	8	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015)	2
MAD2L2	0	SSR4	1	affinity chromatography technology	Hein MY (2015)	1
CHST12	1	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L2	0	DCTN3	2	affinity chromatography technology	Hein MY (2015)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
MAD2L2	0	MAD2L2	0	two hybrid, pull down	Murakumo Y (2001), Murakumo Y (2001)	2
ADAM15	2	TRIP13	0	two hybrid	Rual JF (2005)	1
POLD3	0	MAD2L2	0	affinity chromatography technology	Kim MS (2013)	1
ICAM2	1	MAD2L2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAD2L1	0	REV3L	8	pull down	Murakumo Y (2000)	1
TCF4	26	MAD2L2	0	two hybrid	Rolland T (2014)	1
IKZF1	2	MAD2L2	0	two hybrid	Rolland T (2014)	1
MAD2L2	0	DICER1	4	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	YY1AP1	0	affinity chromatography technology	Choudhury NR (2017)	1
GRPR	0	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
CAMK2B	9	MAD2L2	0	two hybrid	Rolland T (2014)	1
MAD2L2	0	MAD2L1	0	pull down, pull down	Murakumo Y (2000), Murakumo Y (2000)	2
ELK1	2	MAD2L2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study	Zhang L (2007), Zhang L (2007), Zhang L (2007), Zhang L (2007)	4
TRIM27	2	KCTD9	1	two hybrid	Rolland T (2014)	1
NXF1	0	IFNGR1	0	affinity chromatography technology	Castello A (2012)	1
MAD2L2	0	GTF2I	1	affinity chromatography technology	Vermeulen M (2010)	1
SRPRB	0	MAD2L2	0	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	DICER1	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MAD2L2	0	affinity chromatography technology	Choudhury NR (2017)	1
YY1AP1	0	MAD2L2	0	two hybrid, affinity chromatography technology, pull down	Li L (2007), Li L (2007), Li L (2007)	3
SLAMF1	2	ADAM9	0	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L2	0	ATP5O	0	affinity chromatography technology	Hein MY (2015)	1
MAD2L2	0	RAN	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Medendorp K (2009), Medendorp K (2009), Medendorp K (2009)	3
CBX1	0	POGZ	49	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	4
PRCC	0	MAD2L2	0	two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Weterman MA (2001), Weterman MA (2001), Weterman MA (2001), Weterman MA (2001)	4
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
TSPYL6	0	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
HEPACAM2	3	MAD2L2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCF7L2	12	MAD2L2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Hong CF (2009), Hong CF (2009), Hong CF (2009)	3
MAD2L2	0	ADAM9	0	two hybrid, pull down	Nelson KK (1999), Nelson KK (1999)	2
IFNGR1	0	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
POGZ	49	MAD2L2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Vermeulen M (2010), Hein MY (2015)	3
CBX3	1	POGZ	49	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	4
TRIM25	5	FZR1	1	affinity chromatography technology	Choudhury NR (2017)	1
TFR2	3	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
MAD2L2	0	RAD23B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Bhat A (2017), Bhat A (2017), Bhat A (2017), Bhat A (2017)	4
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
ADAM15	2	MAD2L1	0	affinity chromatography technology	Poghosyan Z (2002)	1
MAD2L2	0	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical	Iwai H (2007), Chen J (2001), Chen J (2001), Listovsky T (2013), Listovsky T (2013), Listovsky T (2013), Listovsky T (2013), Listovsky T (2013)	8
NXF1	0	POGZ	49	affinity chromatography technology	Castello A (2012)	1
GYPB	0	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
POGZ	49	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Vermeulen M (2010), Hein MY (2015)	3
TRIM27	2	MAD2L2	0	two hybrid	Rolland T (2014)	1
MOV10	6	POLDIP2	1	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	TRIP13	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
GTF2I	1	RAD23B	1	biochemical	Kristensen AR (2012)	1
MAD2L2	0	REV3L	8	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Murakumo Y (2000), Murakumo Y (2000), Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Hashimoto K (2012), Sharma S (2012), Sharma S (2012), Hara K (2010), Hara K (2010), Hara K (2010), Hara K (2009), Kikuchi S (2012)	13
MOV10	6	POGZ	49	affinity chromatography technology	Castello A (2012)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
MOV10	6	CDC20	1	affinity chromatography technology	Castello A (2012)	1
CDC20	1	MAD2L1	0	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, unspecified method, pull down, affinity chromatography technology	Zhang Y (2001), Sihn CR (2003), Luo X (2000), Sironi L (2001), DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kallio M (1998), Fang G (1998), Fang G (1998), Skoufias DA (2001), Nilsson J (2008), Privette LM (2008), Stegmeier F (2007), Ho CY (2010), Ho CY (2010), Mansfeld J (2011), Gao YF (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Townsend K (2009), Lee YJ (2008), DAngiolella V (2003), Tang Z (2001), Tang Z (2001), Sironi L (2001), Sironi L (2001), Ge S (2009), Mapelli M (2007), Tipton AR (2011), Mondal G (2006), Mondal G (2006), Westhorpe FG (2011), De Antoni A (2005), De Antoni A (2005), Kwan PS (2013), Katayama H (2012), Fava LL (2011), Santaguida S (2011), Mapelli M (2006), Eytan E (2013), Eytan E (2013), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Eytan E (2014), Hein JB (2014), Yen AH (2010), Yen AH (2010), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Sedgwick GG (2016), Sedgwick GG (2016), Izawa D (2012), Izawa D (2012), Jia L (2016), Jia L (2016), Kaisari S (2017), Yang M (2008), Kim S (2010), Kim S (2010)	70
MAD2L2	0	REV1	1	two hybrid, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, pull down	Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Pozo FM (2011), Ohashi E (2004), Hashimoto K (2012), Sharma S (2012), Hara K (2010), Masuda Y (2003), Tissier A (2004), Chun AC (2013), Pustovalova Y (2012), Kikuchi S (2012), Kikuchi S (2012)	15
TRIM25	5	RAD23B	1	affinity chromatography technology	Choudhury NR (2017)	1
LRFN4	2	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L2	0	CLTA	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Medendorp K (2010), Medendorp K (2010), Medendorp K (2010)	3
MAD2L2	0	CBX3	1	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hauri S (2016)	2
RBBP6	7	MAD2L2	0	two hybrid	Wang J (2008)	1
MAD2L2	0	TRIP13	0	two hybrid	Venkatesan K (2009)	1
REL	5	MAD2L2	0	two hybrid	Rolland T (2014)	1
FAM78B	0	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L2	0	CDC20	1	pull down, affinity chromatography technology	Chen J (2001), Chen J (2001)	2
REV3L	8	REV1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sharma S (2012), Sharma S (2012), Hara K (2010)	3
MAD2L2	0	CBX5	3	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hauri S (2016)	2
CBX5	3	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	4
HLA-C	1	MAD2L2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	ADAM15	2	affinity chromatography technology	Choudhury NR (2017)	1
PMEL	8	MAD2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
SLAMF1	2	MAD2L2	0	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	PRCC	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CLTA	1	affinity chromatography technology	Choudhury NR (2017)	1
CDC27	2	MAD2L2	0	affinity chromatography technology	Uzunova K (2012)	1
MOV10	6	MAD2L2	0	affinity chromatography technology	Castello A (2012)	1
MAD2L2	0	KCTD9	1	two hybrid	Rolland T (2014)	1
POLD3	0	REV1	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Kim MS (2013), Kim MS (2013), Pustovalova Y (2016), Pustovalova Y (2016)	4
MOV10	6	IFNGR1	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	POLDIP2	1	affinity chromatography technology	Castello A (2012)	1
CDC27	2	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wassmann K (1998), Kallio M (1998), Li Y (1997), Li Y (1997), Lara-Gonzalez P (2011), Mansfeld J (2011), Visconti R (2010), Ma HT (2011), Sironi L (2001), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Lara-Gonzalez P (2011), Yen AH (2010), Hein MY (2015), Craney A (2016), Sedgwick GG (2016)	18
MAD2L2	0	ADAM15	2	two hybrid	Nelson KK (1999)	1
REV1	1	POLDIP2	1	two hybrid	Tissier A (2010)	1
CHAMP1	8	CBX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3