PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
MERTK	2	TNK2	7	affinity chromatography technology	Mahajan NP (2005)	1
MERTK	2	ITGB5	3	genetic interference	Wu Y (2005)	1
HSP90AA1	7	MERTK	2	affinity chromatography technology	Taipale M (2012)	1
TNK2	7	NEDD4L	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Chan W (2009), Chan W (2009), Chan W (2009), Chan W (2009), Hitomi Y (2013)	5
IKBKG	0	MERTK	2	pull down	Fenner BJ (2010)	1
SKI	3	MERTK	2	affinity chromatography technology	Rashidian J (2015)	1
NEDD4L	3	MERTK	2	enzymatic study	Persaud A (2009)	1
MERTK	2	MERTK	2	affinity chromatography technology, enzymatic study	Wu Y (2005), Wu Y (2005)	2
TNK2	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahajan NP (2005), Mahajan NP (2005), Taipale M (2012), Gao B (2013), Mahendrarajah N (2017), Mahendrarajah N (2017), Mahendrarajah N (2017)	7
GAS6	1	MERTK	2	pull down	Nagata K (1996)	1