PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
C8orf33	3	FST	0	two hybrid	Vinayagam A (2011)	1
FST	0	INHBA	1	x-ray crystallography	Thompson TB (2005)	1
TK1	0	FST	0	two hybrid	Vinayagam A (2011)	1
TXN	1	FST	0	two hybrid	Matsumoto K (2002)	1
FST	0	BMPR1A	5	x-ray crystallography	Thompson TB (2005)	1
INHBE	0	FST	0	pull down	Hashimoto O (2002)	1
MEST	2	FST	0	two hybrid	Vinayagam A (2011)	1
BMPR2	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
FST	0	BMPR2	1	x-ray crystallography	Thompson TB (2005)	1