PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	GMCL1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	TAB2	5	enzymatic study	Wang X (2014)	1
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
TRIM38	3	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
ATXN1	2	HSPA8	4	affinity chromatography technology	Choi JY (2007)	1
NLRP6	2	TAB2	5	affinity chromatography technology	Lin Y (2017)	1
HSPA1A	0	HSPA2	3	biochemical	Havugimana PC (2012)	1
EIF1B	0	TRIM38	3	two hybrid	Rolland T (2014)	1
UBE2U	0	TRIM38	3	two hybrid	van Wijk SJ (2009)	1
SDCBP	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen F (2008), Chen F (2008)	2
TRIM38	3	UBE2D3	1	two hybrid	Napolitano LM (2011)	1
SDCBP	0	TRIM38	3	two hybrid	Rolland T (2014)	1
TRIM38	3	UBE2D1	0	two hybrid	Napolitano LM (2011)	1
TRIM38	3	GMCL1	0	two hybrid	Rolland T (2014)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
TRIM38	3	TSPYL4	2	two hybrid	Rolland T (2014)	1
TICAM1	3	TRIM38	3	affinity chromatography technology	Xue Q (2012)	1
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
ATXN1	2	UBE2E3	0	two hybrid	Lim J (2006)	1
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
HSPA1A	0	TRIM38	3	two hybrid	Wang J (2011)	1
TAB3	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology	Ishitani T (2003), Kanayama A (2004), Shinohara H (2016)	3
TRIM38	3	TRAF6	0	affinity chromatography technology	Zhao W (2012)	1
ELAVL1	0	SDCBP	0	two hybrid	Rolland T (2014)	1
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
TRIM38	3	GORASP2	1	two hybrid	Rolland T (2014)	1
NLRP6	2	TRIM38	3	affinity chromatography technology	Lin Y (2017)	1
ELAVL1	0	TRIM38	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
TAB3	1	TRIM38	3	affinity chromatography technology, affinity chromatography technology	Hu MM (2014), Hu MM (2014)	2
ATXN1	2	UBE2E1	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Kang AR (2015)	6
HSPA8	4	TRIM38	3	two hybrid	Rolland T (2014)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HSPA2	3	TRIM38	3	two hybrid	Rolland T (2014)	1
TRIM38	3	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
NLRP6	2	TAB3	1	affinity chromatography technology	Lin Y (2017)	1
TRIM38	3	UBE2D2	0	two hybrid	Napolitano LM (2011)	1
TRIM38	3	UBE2E3	0	two hybrid	Napolitano LM (2011)	1
ELAVL1	0	UBE2E2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	EIF1B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM38	3	TRIM38	3	two hybrid	Rolland T (2014)	1
TAB2	5	TRIM38	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Hu MM (2014), Hu MM (2014), Hu MM (2014)	3
ATXN1	2	EIF1B	0	two hybrid	Suter B (2013)	1
UBE2I	0	TRIM38	3	two hybrid	Rolland T (2014)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
HSPA2	3	HSPA8	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Huttlin EL (2017)	4
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TRIM38	3	AZI2	1	affinity chromatography technology, affinity chromatography technology	Zhao W (2012), Zhao W (2012)	2
STXBP1	38	TRIM38	3	two hybrid	Rolland T (2014)	1
ATXN1	2	TRIM38	3	two hybrid	Suter B (2013)	1
ATXN1	2	HSPA1A	0	two hybrid	Lim J (2006)	1
TRIM38	3	UBE2E2	1	two hybrid	Napolitano LM (2011)	1
RFC5	2	TRIM38	3	two hybrid	Rolland T (2014)	1