PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPA1	1	PRMT8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Huttlin EL (2017)	3
KHDRBS2	1	HNRNPA1	1	affinity chromatography technology	Jeronimo C (2007)	1
ESR1	0	HNRNPD	3	pull down	Nalvarte I (2010)	1
KHDRBS2	1	PRMT1	3	affinity chromatography technology	Jeronimo C (2007)	1
HNRNPR	3	SNRNP70	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
SYNCRIP	6	PABPC1	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TP63	0	HNRNPK	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amoresano A (2010), Amoresano A (2010), Amoresano A (2010)	3
SYT8	1	SYNCRIP	6	pull down, affinity chromatography technology	Mizutani A (2000), Mizutani A (2000)	2
DDX5	2	HNRNPK	4	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
U2AF2	7	DHX15	5	affinity chromatography technology	Whisenant TC (2015)	1
SYNCRIP	6	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HNRNPK	4	SNRNP70	2	biochemical	Havugimana PC (2012)	1
TARDBP	4	HNRNPU	12	affinity chromatography technology	Freibaum BD (2010)	1
PRMT8	2	PRMT1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lee J (2005), Weimann M (2013), Weimann M (2013), Weimann M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	7
TP63	0	HNRNPR	3	affinity chromatography technology	Amoresano A (2010)	1
HNRNPR	3	DDX5	2	biochemical	Wan C (2015)	1
HNRNPK	4	HNRNPU	12	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HNRNPA1	1	DDX3X	52	affinity chromatography technology	Roy R (2014)	1
PRMT8	2	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPU	12	FAM120A	3	affinity chromatography technology	Hein MY (2015)	1
TP63	0	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Amoresano A (2010), Amoresano A (2010)	2
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPU	12	YBX1	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
HNRNPU	12	HNRNPA1	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Hein MY (2015), Hein MY (2015)	5
TRIM25	5	PRMT1	3	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPK	4	PRMT1	3	affinity chromatography technology, enzymatic study	Cote J (2003), Wada K (2002)	2
DHX15	5	PABPC1	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
HNRNPA1	1	HMGA1	0	far western blotting	Sgarra R (2008)	1
SYNCRIP	6	U2AF2	7	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015), Whisenant TC (2015)	3
HNRNPA1	1	DDX5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Roy R (2014)	3
HNRNPA1	1	DHX15	5	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
SYT9	3	SYNCRIP	6	pull down, affinity chromatography technology	Mizutani A (2000), Mizutani A (2000)	2
HNRNPD	3	FAM120A	3	affinity chromatography technology	Hein MY (2015)	1
U2AF2	7	HNRNPA1	1	affinity chromatography technology	Whisenant TC (2015)	1
TRIM25	5	HNRNPR	3	affinity chromatography technology	Choudhury NR (2017)	1
DDX5	2	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
HMGA2	1	SYNCRIP	6	pull down, far western blotting	Sgarra R (2008), Sgarra R (2008)	2
HNRNPR	3	TARDBP	4	biochemical, affinity chromatography technology	Havugimana PC (2012), Freibaum BD (2010)	2
TRIM25	5	DDX5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Choudhury NR (2017)	3
DHX15	5	SYNCRIP	6	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
DDX3X	52	HNRNPR	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TARDBP	4	DDX3X	52	affinity chromatography technology	Freibaum BD (2010)	1
TARDBP	4	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Freibaum BD (2010), Freibaum BD (2010)	2
PRMT1	3	HNRNPA1	1	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Lin WJ (1996), Jeronimo C (2007), Robin-Lespinasse Y (2007), Chan JY (2009), Chan JY (2009), Chan JY (2009), Roy R (2014)	7
HNRNPA1	1	APP	1	pull down	Olah J (2011)	1
HNRNPU	12	SNRNP70	2	biochemical	Havugimana PC (2012)	1
TARDBP	4	APP	1	pull down	Olah J (2011)	1
KHDRBS2	1	DDX5	2	affinity chromatography technology	Jeronimo C (2007)	1
APP	1	HMGA1	0	pull down	Virok DP (2011)	1
KHDRBS2	1	TARDBP	4	affinity chromatography technology	Jeronimo C (2007)	1
HNRNPU	12	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
HNRNPU	12	HNRNPR	3	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
KHDRBS2	1	HNRNPR	3	affinity chromatography technology, two hybrid, biochemical	Jeronimo C (2007), Rolland T (2014), Wan C (2015)	3
DHX15	5	HNRNPR	3	biochemical	Wan C (2015)	1
HNRNPU	12	PABPC1	5	biochemical	Havugimana PC (2012)	1
HNRNPD	3	HNRNPR	3	biochemical	Havugimana PC (2012)	1
MAEL	0	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Yuan L (2014), Yuan L (2014)	2
HNRNPA1	1	HNRNPR	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Huttlin EL (2015), Roy R (2014), Hein MY (2015), Huttlin EL (2017)	7
HABP4	1	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology, two hybrid	Bressan GC (2009), Bressan GC (2009), Bressan GC (2009)	3
SYNCRIP	6	FAM120A	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
SNRNP70	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HNRNPK	4	KHDRBS2	1	two hybrid, affinity chromatography technology	Rual JF (2005), Jeronimo C (2007)	2
HNRNPD	3	HMGA1	0	far western blotting	Sgarra R (2008)	1
KHDRBS2	1	YBX1	1	affinity chromatography technology	Jeronimo C (2007)	1
HNRNPA1	1	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Hein MY (2015)	4
HNRNPK	4	YBX1	1	biochemical	Havugimana PC (2012)	1
PRMT8	2	FAM120A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYT7	4	SYNCRIP	6	pull down, affinity chromatography technology	Mizutani A (2000), Mizutani A (2000)	2
KHDRBS2	1	SYNCRIP	6	affinity chromatography technology, biochemical	Jeronimo C (2007), Wan C (2015)	2
TARDBP	4	DDX5	2	affinity chromatography technology	Freibaum BD (2010)	1
HNRNPR	3	PABPC1	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MAEL	0	YBX1	1	affinity chromatography technology, affinity chromatography technology	Yuan L (2014), Yuan L (2014)	2
TARDBP	4	FAM120A	3	affinity chromatography technology	Freibaum BD (2010)	1
HNRNPU	12	SYNCRIP	6	two hybrid, two hybrid, biochemical, biochemical, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
TARDBP	4	U2AF2	7	biochemical	Havugimana PC (2012)	1
ESR1	0	DDX3X	52	affinity chromatography technology, affinity chromatography technology, pull down	Ambrosino C (2010), Tarallo R (2011), Nalvarte I (2010)	3
HNRNPA1	1	HNRNPK	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
TRIM25	5	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
ESR1	0	HNRNPA1	1	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
SYNCRIP	6	YBX1	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
HNRNPU	12	DDX5	2	affinity chromatography technology	Hein MY (2015)	1
U2AF2	7	PABPC1	5	affinity chromatography technology	Whisenant TC (2015)	1
HNRNPA1	1	TARDBP	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Freibaum BD (2010)	3
SYNCRIP	6	SNRNP70	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
MAEL	0	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Yuan L (2014), Yuan L (2014)	2
PRMT1	3	SYNCRIP	6	enzymatic study, affinity chromatography technology, two hybrid	Wada K (2002), Weimann M (2013), Weimann M (2013)	3
HNRNPK	4	U2AF2	7	biochemical, two hybrid, two hybrid, affinity chromatography technology	Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Whisenant TC (2015)	4
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
A1CF	1	APOBEC1	0	affinity chromatography technology, pull down, affinity chromatography technology	Blanc V (2001), Blanc V (2001), Mehta A (2000)	3
HNRNPK	4	HNRNPR	3	biochemical	Havugimana PC (2012)	1
HNRNPU	12	HNRNPD	3	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Hein MY (2015), Hein MY (2015)	4
DHX15	5	HNRNPK	4	biochemical	Havugimana PC (2012)	1
HNRNPD	3	SYNCRIP	6	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
HNRNPR	3	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
HNRNPA1	1	HNRNPD	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	4
SYNCRIP	6	PRMT8	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Venkatesan K (2009), Weimann M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
PRMT1	3	HNRNPU	12	enzymatic study	Lee J (2002)	1
TRIM25	5	HNRNPA1	1	affinity chromatography technology	Choudhury NR (2017)	1
ESR1	0	U2AF2	7	affinity chromatography technology	Tarallo R (2011)	1
HNRNPD	3	YBX1	1	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
SYNCRIP	6	A1CF	1	pull down, two hybrid, affinity chromatography technology, pull down	Lau PP (2001), Blanc V (2001), Blanc V (2001), Blanc V (2001)	4
HABP4	1	YBX1	1	two hybrid, two hybrid	Nery FC (2006), Bressan GC (2009)	2
ESR1	0	HNRNPK	4	affinity chromatography technology	Tarallo R (2011)	1
PRMT8	2	HNRNPR	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
SYNCRIP	6	HNRNPR	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
HNRNPA1	1	FAM120A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Roy R (2014), Hein MY (2015), Huttlin EL (2017)	4
PRMT1	3	ESR1	0	pull down	Koh SS (2001)	1
DDX5	2	DHX15	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HABP4	1	PRMT1	3	two hybrid, pull down	Stelzl U (2005), Stelzl U (2005)	2
ESR1	0	HNRNPR	3	affinity chromatography technology	Tarallo R (2011)	1
ESR1	0	YBX1	1	affinity chromatography technology	Tarallo R (2011)	1
DDX5	2	SYNCRIP	6	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HNRNPK	4	TARDBP	4	biochemical	Havugimana PC (2012)	1
HNRNPK	4	SYNCRIP	6	biochemical, two hybrid, two hybrid	Havugimana PC (2012), Hegele A (2012), Hegele A (2012)	3
TRIM25	5	FAM120A	3	affinity chromatography technology	Choudhury NR (2017)	1
PRMT8	2	HNRNPK	4	affinity chromatography technology	Huttlin EL (2017)	1
SYNCRIP	6	TARDBP	4	biochemical, affinity chromatography technology	Havugimana PC (2012), Freibaum BD (2010)	2
MAEL	0	DDX3X	52	affinity chromatography technology	Yuan L (2014)	1
ESR1	0	PABPC1	5	affinity chromatography technology	Tarallo R (2011)	1
DDX3X	52	U2AF2	7	biochemical	Havugimana PC (2012)	1
DDX3X	52	SYNCRIP	6	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ESR1	0	DHX15	5	affinity chromatography technology	Tarallo R (2011)	1
MAEL	0	HNRNPA1	1	affinity chromatography technology	Yuan L (2014)	1
HNRNPA1	1	PABPC1	5	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014)	4
ESR1	0	DDX5	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ambrosino C (2010), Ambrosino C (2010), Fujita T (2003), Mooney SM (2010), Tarallo R (2011), Mooney SM (2010)	6
SNRNP70	2	PABPC1	5	affinity chromatography technology	Huttlin EL (2017)	1
SNRNP70	2	PRMT1	3	biochemical	Wan C (2015)	1
TRIM25	5	TARDBP	4	affinity chromatography technology	Choudhury NR (2017)	1
APOBEC1	0	SYNCRIP	6	two hybrid, pull down	Lau PP (2001), Lau PP (2001)	2
TRIM25	5	YBX1	1	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPD	3	PABPC1	5	affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Laroia G (1999), Havugimana PC (2012), Lu JY (2006), He C (2006)	4
SYNCRIP	6	HMGA1	0	far western blotting, pull down	Sgarra R (2008), Sgarra R (2008)	2
PRMT1	3	HNRNPR	3	enzymatic study, two hybrid, two hybrid	Wada K (2002), Stelzl U (2005), Rolland T (2014)	3
TARDBP	4	HNRNPD	3	affinity chromatography technology	Davis SA (2018)	1
KHDRBS2	1	HNRNPD	3	affinity chromatography technology	Jeronimo C (2007)	1
HNRNPK	4	HNRNPD	3	two hybrid, two hybrid, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Hein MY (2015)	3
SNRNP70	2	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
HNRNPK	4	PABPC1	5	affinity chromatography technology, biochemical, two hybrid, two hybrid	Brendel C (2004), Havugimana PC (2012), Hegele A (2012), Hegele A (2012)	4
TRIM25	5	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
U2AF2	7	YBX1	1	affinity chromatography technology	Whisenant TC (2015)	1
U2AF2	7	HNRNPD	3	two hybrid, two hybrid, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Whisenant TC (2015)	3
ESR1	0	SYNCRIP	6	affinity chromatography technology, pull down, affinity chromatography technology	Tarallo R (2011), Nalvarte I (2010), Han SJ (2016)	3