PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKDC	12	CIB1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wu X (1997), Wu X (1997), Lee GE (2004), Lee GE (2004)	4
PSEN2	3	CIB1	2	two hybrid, pull down, genetic interference, affinity chromatography technology	Stabler SM (1999), Stabler SM (1999), Stabler SM (1999), Stabler SM (1999)	4
EGLN3	0	CIB1	2	affinity chromatography technology	Rodriguez J (2016)	1
ITGA5	7	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
ITGB3	6	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
NBR1	0	CIB1	2	two hybrid	Whitehouse C (2002)	1
EGLN3	0	CDK4	2	affinity chromatography technology	Rodriguez J (2016)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
EGLN3	0	PRKDC	12	affinity chromatography technology	Rodriguez J (2016)	1
ZDHHC17	1	CIB1	2	two hybrid	Butland SL (2014)	1
EGLN3	0	UBR5	13	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	AURKB	2	affinity chromatography technology	Rodriguez J (2016)	1
CDK4	2	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKB	2	UBR5	13	affinity chromatography technology	Fogeron ML (2013)	1
CIB1	2	PTK2	2	affinity chromatography technology	Naik MU (2003)	1
CIB1	2	PLK3	0	affinity chromatography technology	Holtrich U (2000)	1
UPK1A	1	CIB1	2	affinity chromatography technology	Huttlin EL (2017)	1
PLK2	0	CIB1	2	affinity chromatography technology	Ma S (2003)	1
ITGB3	6	PTK2	2	pull down, affinity chromatography technology, affinity chromatography technology	Eliceiri BP (2002), Chung J (1997), Lee DY (2010)	3
UBR5	13	TERT	7	affinity chromatography technology, affinity chromatography technology	Jung HY (2013), Jung HY (2013)	2
CDK4	2	CIB1	2	two hybrid	Wang J (2011)	1
CDK4	2	PRKDC	12	genetic interference	Shen JP (2017)	1
CDK4	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CIB1	2	UBR5	13	pull down, two hybrid, affinity chromatography technology	Henderson MJ (2002), Henderson MJ (2002), Henderson MJ (2002)	3
EGLN3	0	MAP3K5	1	affinity chromatography technology	Rodriguez J (2016)	1
AURKB	2	CIB1	2	two hybrid	Wang J (2011)	1
TMC7	3	CIB1	2	affinity chromatography technology	Huttlin EL (2017)	1
RAC3	4	CIB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Haataja L (2002), Haataja L (2002), Haataja L (2002)	3
CIB1	2	MAP3K5	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Yoon KW (2009), Yoon KW (2009), Yoon KW (2009), Yoon KW (2009)	4
ITGB3	6	ITGA5	7	affinity chromatography technology, biochemical, pull down	Wang L (2012), Wan C (2015), Vallar L (1999)	3
MAP3K5	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ITGA2B	2	CIB1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Naik UP (1997), Naik UP (1997), Yamodo IH (2012), Yamodo IH (2012)	4
CIB1	2	TERT	7	pull down, two hybrid, pull down, affinity chromatography technology	Lee JH (2010), Lee GE (2004), Lee GE (2004), Lee GE (2004)	4
EXOSC10	1	CIB1	2	two hybrid	Lehner B (2004)	1
ITGA2B	2	ITGB3	6	pull down, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yin H (2006), Wang R (1997), Wang R (1997), Ulmer TS (2001), Ulmer TS (2001), Afrasiabi A (2008), Rosenberg N (2004), Vallar L (1999), Ward CM (2000)	9
NRIP1	4	CIB1	2	two hybrid	Albers M (2005)	1
PSEN1	11	CIB1	2	two hybrid	Stabler SM (1999)	1