PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEBPE	0	PSAT1	1	two hybrid	Wang J (2011)	1
ATF4	2	JUN	0	pull down, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Hai T (1991), Bandyopadhyay S (2010), Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	5
CEBPE	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPA	0	PIAS1	4	pull down	Chih DY (2004)	1
NELFB	7	FOS	0	affinity chromatography technology, pull down	Zhong H (2004), Zhong H (2004)	2
CEBPE	0	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
E2F1	0	CEBPE	0	affinity chromatography technology, pull down	Gery S (2004), Gery S (2004)	2
MYB	3	PIAS1	4	two hybrid, pull down, pull down	Alm-Kristiansen AH (2011), Ledsaak M (2016), Ledsaak M (2016)	3
CEBPE	0	TAF5L	1	two hybrid	Ravasi T (2010)	1
BATF	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
FOSL1	0	LDOC1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
CEBPE	0	MLLT6	2	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
JUN	0	BATF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPE	0	EDA2R	0	two hybrid	Wang J (2011)	1
CEBPE	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down	Reinke AW (2013), Reinke AW (2013), Reddy KV (2003)	3
CEBPA	0	RB1	2	affinity chromatography technology, affinity chromatography technology	Bararia D (2008), Wang GL (2004)	2
CEBPE	0	MED16	5	two hybrid	Ravasi T (2010)	1
PIAS1	4	JUN	0	pull down, enzymatic study	Schmidt D (2002), Schmidt D (2002)	2
CEBPE	0	DDIT3	1	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
CEBPE	0	GPR22	0	two hybrid	Wang J (2011)	1
CEBPA	0	ATF5	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPG	1	MLLT6	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
UBE2I	0	RB1	2	enzymatic study, pull down	Ledl A (2005), Ledl A (2005)	2
CEBPE	0	ZFP2	1	two hybrid	Ravasi T (2010)	1
FOS	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NFATC2	1	ZMYM2	5	affinity chromatography technology	Gabriel CH (2016)	1
CEBPE	0	COPS3	1	two hybrid	Chih DY (2004)	1
MYB	3	CEBPE	0	pull down	Verbeek W (1999)	1
COPS3	1	HSP90AA1	7	affinity chromatography technology	Min KW (2005)	1
BATF2	0	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPE	0	CSNK1A1L	1	two hybrid	Wang J (2011)	1
DENND4A	8	SIPA1L1	10	affinity chromatography technology	Boldt K (2016)	1
BATF	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPE	0	ZNF384	3	two hybrid	Ravasi T (2010)	1
CEBPE	0	CEBPG	1	two hybrid, pull down, fluorescent resonance energy transfe	Chih DY (2004), Chih DY (2004), Reinke AW (2013)	3
KDM2B	11	JUN	0	affinity chromatography technology	Koyama-Nasu R (2007)	1
HSP90AA1	7	ATF3	0	affinity chromatography technology	Taipale M (2012)	1
CEBPE	0	UBE2I	0	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
CEBPE	0	IL7	2	two hybrid	Wang J (2011)	1
CEBPG	1	FOS	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
HSP90AA1	7	CEBPE	0	affinity chromatography technology	Taipale M (2012)	1
PSAT1	1	STAT6	1	biochemical	Havugimana PC (2012)	1
FOSL1	0	JUN	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Pognonec P (1997), Pognonec P (1997), Kumar NV (2001), Kumar NV (2001), Reinke AW (2013), Reinke AW (2013)	6
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
ATF3	0	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPG	1	ATF4	2	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
ATF3	0	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
NFATC2	1	FOS	0	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
CEBPE	0	LDOC1	0	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
CEBPA	0	JUN	0	affinity chromatography technology	Zada AA (2006)	1
NFATC2	1	CEBPE	0	affinity chromatography technology	Gabriel CH (2016)	1
BATF3	0	BATF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	CEBPA	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Marwarha G (2016), Marwarha G (2016), Marwarha G (2016)	3
UBE2I	0	FOS	0	enzymatic study, enzymatic study, enzymatic study	Jakobs A (2007), Bossis G (2005), Guo D (2005)	3
ATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF3	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPE	0	NELFB	7	two hybrid	Ravasi T (2010)	1
DDIT3	1	BATF	0	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Rual JF (2005), Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	4
CEBPE	0	STAT6	1	two hybrid	Chih DY (2004)	1
DDIT3	1	FOS	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
COPS3	1	ELOB	1	affinity chromatography technology	Olma MH (2009)	1
BATF2	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	3
CEBPE	0	POU2F1	5	two hybrid	Ravasi T (2010)	1
DDIT3	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPE	0	GTF2A1L	0	two hybrid	Ravasi T (2010)	1
NFATC2	1	JUN	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nguyen TN (2010), Nguyen TN (2010), Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	5
CEBPE	0	PIAS1	4	two hybrid, pull down, affinity chromatography technology	Chih DY (2004), Chih DY (2004), Chih DY (2004)	3
CEBPA	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
CEBPG	1	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFATC2	1	ZNF384	3	affinity chromatography technology	Gabriel CH (2016)	1
JUN	0	HSP90AA1	7	two hybrid, pull down	Bandyopadhyay S (2010), Miyamoto-Sato E (2010)	2
CEBPE	0	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Gery S (2004), Gery S (2004), Gery S (2004)	3
CCT7	2	CEBPE	0	two hybrid	Wang J (2011)	1
CEBPG	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF	0	CEBPE	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPA	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
STAT6	1	JUN	0	affinity chromatography technology, affinity chromatography technology	Sahoo A (2011), Sahoo A (2011)	2
BATF2	0	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	BATF3	0	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
NELFB	7	JUN	0	affinity chromatography technology, pull down	Zhong H (2004), Zhong H (2004)	2
UBE2I	0	ATF3	0	enzymatic study	Wang CM (2012)	1
HSP90AA1	7	PSAT1	1	affinity chromatography technology	Falsone SF (2005)	1
BATF2	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF3	0	CEBPE	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF3	0	JUN	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Pearson AG (2003), Chen BP (1996), Hai T (1991), Filen S (2010), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Li X (2015)	8
CEBPE	0	ELOB	1	two hybrid	Ravasi T (2010)	1
CEBPE	0	ZMYM2	5	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
CEBPE	0	FOS	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	JUN	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
BATF	0	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	GTF2A1L	0	two hybrid	Ravasi T (2010)	1
ATF4	2	FOSL1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPE	0	CEBPE	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
JUN	0	RB1	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Nishitani J (1999), Nishitani J (1999), Nishitani J (1999), Nead MA (1998), Nead MA (1998)	5
CEBPE	0	TBX2	1	two hybrid	Ravasi T (2010)	1
BATF2	0	JUN	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
JUN	0	UBE2I	0	two hybrid, enzymatic study	Goettlicher M (1996), Muller S (2000)	2
KDM2B	11	FOS	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Han XR (2016), Han XR (2016), Han XR (2016)	3
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
BATF3	0	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	LDOC1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NFATC2	1	RB1	2	affinity chromatography technology	Gabriel CH (2016)	1
GATA1	1	CEBPE	0	affinity chromatography technology	Du J (2002)	1
CEBPE	0	KDM2B	11	two hybrid	Ravasi T (2010)	1
ATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	COPS3	1	biochemical	Huang X (2012)	1
CEBPE	0	DENND4A	8	two hybrid	Ravasi T (2010)	1
CEBPE	0	ATF5	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
UBE2I	0	ZMYM2	5	two hybrid	Bandyopadhyay S (2010)	1
MYB	3	UBE2I	0	two hybrid, enzymatic study	Bies J (2002), Kanei-Ishii C (2012)	2
HSP90AA1	7	RB1	2	genetic interference	Srivas R (2016)	1
CEBPG	1	DDIT3	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Hattori T (2003), Rolland T (2014)	3
MLLT6	2	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF4	2	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
CEBPE	0	ALX4	1	two hybrid	Ravasi T (2010)	1
CEBPE	0	SIPA1L1	10	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
ATF4	2	ATF3	0	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wang Q (2009), Reinke AW (2013), Reinke AW (2013)	3
CEBPE	0	BATF2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
BATF3	0	JUN	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Iacobelli M (2000), Reinke AW (2013), Reinke AW (2013), Li X (2015), Huttlin EL (2017)	5
RB1	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nicolas E (2001), Pardo PS (2002), Choubey D (1996), Fajas L (2000), Dyson N (1993), Dyson N (1993), Wu CL (1995), Taniura H (1998), Dai Y (2003), Fedele M (2006), Fedele M (2006), Brown VD (2002), De Blasio A (2005), Chau CM (2008), Dasgupta P (2004), Yang L (2011), Kruetzfeldt M (2005), Harbour JW (1999), Lee SJ (1998), Gao D (2009), Delston RB (2011), Gupta K (2000), Sdek P (2004), Flemington EK (1993), Chang YH (2012), Inoue Y (2007), Inoue Y (2007), Inoue Y (2007), Liu X (2006), Moberg K (1996), Knudsen ES (1996), Brown VD (1999), Brown VD (1999), Whitaker LL (1998), Whitaker LL (1998), Hagemeier C (1993), Bhat UG (1999), Xiao B (2003), Xiao B (2003), Vidal M (1996), Markham D (2006), Markham D (2006), Ianari A (2009), Ianari A (2009), Dhillon NK (2002), Knudsen ES (1997), Knudsen ES (1997), Gery S (2004), Gery S (2004), Kashuba E (2008), Kashuba E (2008), Pearson A (1997), Ginsberg D (1994), Welch PJ (1995), Wang J (2009), Aoki I (2012), Trimarchi JM (1998), Kumari A (2015), Gamell C (2017), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	63
FOS	0	RB1	2	pull down	Nead MA (1998)	1