Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PROCR 10544 PHOSPHATIDYLETHANOLAMINE CHEMBL448115 DrugBank 17139284, 17016423
PROCR 10544 DROTRECOGIN ALFA (ACTIVATED) CHEMBL2109065 DrugBank 9529319, 12871285, 17566522, 15118520, 12353077

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PROCR rs1415774 G warfarin dosage no Samples, genotypes and INRs from a cohort of 551 patients were used to derive an algorithm which was used to predict daily warfarin maintenance dose in a second cohort of 236 patients. Note: the authors state that "SNPs were tested for deviations from HWE using the chi-squared test, and for their association with the warfarin dose by Spearman correlation analysis using a *co-dominant* model." Allele G is not associated with dose of warfarin in people with heart valve replacement as compared to allele A. 25126975 1184757065