PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBQLN1	1	APP	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Stieren ES (2011), Stieren ES (2011), Hiltunen M (2006)	3
NOS2	6	AGR2	0	affinity chromatography technology	Foster MW (2013)	1
AGR2	0	DAG1	3	two hybrid	Fletcher GC (2003)	1
UBQLN4	2	AGR2	0	two hybrid	Lim J (2006)	1
AGR2	0	UBQLN1	1	two hybrid	Rolland T (2014)	1
AGR2	0	CCDC90B	2	two hybrid	Stelzl U (2005)	1
NOS2	6	HUWE1	22	affinity chromatography technology	Foster MW (2013)	1
NPM1	0	AGR2	0	affinity chromatography technology	Chen R (2013)	1
ATP4A	6	AGR2	0	affinity chromatography technology	Lapierre LA (2007)	1
FOXA1	2	AGR2	0	affinity chromatography technology	Jozwik KM (2016)	1
HUWE1	22	NPM1	0	affinity chromatography technology	Thompson JW (2014)	1
NOS2	6	NPM1	0	affinity chromatography technology	Foster MW (2013)	1
AGR2	0	APP	1	pull down	Olah J (2011)	1
POU5F1	0	AGR2	0	affinity chromatography technology	Hawkins PG (2010)	1
AGR2	0	MED31	0	two hybrid	Stelzl U (2005)	1
NPM1	0	APP	1	pull down	Olah J (2011)	1
FABP2	1	AGR2	0	two hybrid	Rolland T (2014)	1
AGR2	0	LYPD3	0	two hybrid	Fletcher GC (2003)	1
NUP62CL	0	APP	1	pull down	Olah J (2011)	1
HUWE1	22	AGR2	0	affinity chromatography technology	Thompson JW (2014)	1
AGR2	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
AGR2	0	BRD7	2	two hybrid	Stelzl U (2005)	1
AGR2	0	CATSPER1	2	two hybrid	Rolland T (2014)	1
AGR2	0	NUP62CL	0	two hybrid	Rolland T (2014)	1
MLH1	6	AGR2	0	two hybrid	Brieger A (2010)	1
POU5F1	0	HUWE1	22	affinity chromatography technology	Oliviero G (2015)	1
POM121	5	AGR2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
ZNF131	0	AGR2	0	affinity chromatography technology	Varier RA (2016)	1
KRT31	0	AGR2	0	two hybrid	Rolland T (2014)	1