PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	RPL4	4	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	FRS2	0	bioid	Guo Z (2014)	1
SOS1	5	ABL1	9	affinity chromatography technology	Puil L (1994)	1
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
SOS1	5	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1
NTRK1	1	VCL	6	affinity chromatography technology	Emdal KB (2015)	1
CBL	7	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, far western blotting, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Soubeyran P (2003), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Patel H (2006), Johnson KJ (2009), Shishido T (2000), Shishido T (2000), Shishido T (2000), Gaston I (2004), Jain SK (1997), Reedquist KA (1996), Bhat A (1997), Bhat A (1997), Bhat A (1997), Grossmann AH (2004), Brehme M (2009), Brehme M (2009), Brehme M (2009), Nishihara T (2003), Tsukahara F (2010)	21
CDH1	4	SORBS1	2	bioid	Guo Z (2014)	1
SH2B2	1	SORBS1	2	affinity chromatography technology, affinity chromatography technology	Limpert AS (2007), Ahn MY (2004)	2
KHDRBS1	1	NCK2	2	unspecified method	Asbach B (2012)	1
SORBS1	2	NCK2	2	affinity chromatography technology	Cowan CA (2001)	1
NTRK1	1	G3BP1	4	affinity chromatography technology	Emdal KB (2015)	1
SOS1	5	FRS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foehr ED (2000), Wong A (2002), Kouhara H (1997), Lao DH (2006)	4
CDH1	4	VCL	6	affinity chromatography technology, affinity chromatography technology, bioid	Hazan RB (1997), Hazan RB (1998), Guo Z (2014)	3
FBF1	2	CBL	7	bioid	Gupta GD (2015)	1
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
INSR	9	KHDRBS1	1	affinity chromatography technology	Sanchez-Margalet V (2001)	1
FRS2	0	NTRK1	1	pull down, two hybrid	Meakin SO (1999), Meakin SO (1999)	2
CASP8	1	SORBS1	2	affinity chromatography technology	Zhang M (2003)	1
SORBS1	2	INSM1	1	two hybrid, pull down, affinity chromatography technology	Xie J (2002), Xie J (2002), Xie J (2002)	3
NTRK1	1	EIF6	2	affinity chromatography technology	Emdal KB (2015)	1
EFNB1	0	SORBS1	2	affinity chromatography technology, imaging technique	Cowan CA (2001), Cowan CA (2001)	2
SRC	2	KHDRBS1	1	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Stelzl U (2005), Oneyama C (2002), Koch CA (1992), Shen Z (1999), Shen Z (1999), Finan PM (1996), Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004), Pincheira R (2008), Wong G (1992), Williger BT (1997), Wong BR (1999)	14
FLOT1	0	CBL	7	pull down	Baumann CA (2000)	1
CDK4	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
NTRK1	1	KHDRBS1	1	affinity chromatography technology	Emdal KB (2015)	1
RPL4	4	SORBS1	2	two hybrid	Wang J (2011)	1
INPPL1	6	SORBS1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Vandenbroere I (2003), Vandenbroere I (2003)	3
CDH1	4	YWHAB	1	bioid	Guo Z (2014)	1
CEP128	1	SORBS1	2	bioid	Gupta GD (2015)	1
SH2B2	1	INSR	9	affinity chromatography technology, affinity chromatography technology, two hybrid	Onnockx S (2008), Onnockx S (2008), Ahn MY (2004)	3
FBF1	2	VCL	6	bioid	Gupta GD (2015)	1
CNTRL	5	SORBS1	2	bioid	Gupta GD (2015)	1
CDK4	2	SORBS1	2	affinity chromatography technology	Hein MY (2015)	1
NCK2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buvall L (2013), Buvall L (2013), Huttlin EL (2015), Huttlin EL (2017)	4
NTRK1	1	YWHAB	1	affinity chromatography technology	Emdal KB (2015)	1
YWHAB	1	SORBS1	2	affinity chromatography technology	Couzens AL (2013)	1
SH2B2	1	INPPL1	6	affinity chromatography technology	Onnockx S (2008)	1
YWHAB	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
SRC	2	EFNB1	0	enzymatic study	Holland SJ (1996)	1
SORBS1	2	VCL	6	pull down, affinity chromatography technology, affinity chromatography technology	Mandai K (1999), Mandai K (1999), Zhang M (2003)	3
NTRK1	1	MAP4K3	1	affinity chromatography technology	Emdal KB (2015)	1
EIF6	2	SORBS1	2	affinity chromatography technology	Ewing RM (2007)	1
CDH1	4	INPPL1	6	bioid	Guo Z (2014)	1
INSR	9	SORBS1	2	affinity chromatography technology	Lin WH (2001)	1
LATS2	1	AFDN	10	affinity chromatography technology	Couzens AL (2013)	1
CEP128	1	CBL	7	bioid	Gupta GD (2015)	1
INSR	9	FRS2	0	enzymatic study	Delahaye L (2000)	1
NTRK1	1	AFDN	10	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	INPPL1	6	affinity chromatography technology	Emdal KB (2015)	1
PILRA	0	SORBS1	2	two hybrid	Wang J (2011)	1
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
YWHAB	1	AFDN	10	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
TENM1	4	SORBS1	2	two hybrid, affinity chromatography technology	Nunes SM (2005), Nunes SM (2005)	2
FBF1	2	FLOT1	0	bioid	Gupta GD (2015)	1
ABL1	9	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Brehme M (2009), Brehme M (2009)	3
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	AFDN	10	bioid	Guo Z (2014)	1
ABL1	9	LATS2	1	affinity chromatography technology, enzymatic study	Reuven N (2013), Reuven N (2013)	2
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CDK4	2	affinity chromatography technology	Emdal KB (2015)	1
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
G3BP1	4	YWHAB	1	affinity chromatography technology	Jain S (2016)	1
CDH1	4	FLOT1	0	bioid	Guo Z (2014)	1
NCK2	2	EFNB1	0	pull down, affinity chromatography technology, imaging technique	Cowan CA (2001), Cowan CA (2001), Cowan CA (2001)	3
CDK6	0	SORBS1	2	enzymatic study	Anders L (2011)	1
G3BP1	4	SORBS1	2	affinity chromatography technology	Jain S (2016)	1
SH2B2	1	CBL	7	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wakioka T (1999), Ng C (2008), Hu J (2005), Hu J (2005), Onnockx S (2008), Yokouchi M (1999), Yokouchi M (1999)	7
FBF1	2	SORBS1	2	bioid	Gupta GD (2015)	1
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
NTRK1	1	CDK6	0	affinity chromatography technology	Emdal KB (2015)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
SLC10A3	0	SORBS1	2	two hybrid	Wang J (2011)	1
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
AFDN	10	SORBS1	2	affinity chromatography technology, pull down	Mandai K (1999), Mandai K (1999)	2
FLOT1	0	SORBS1	2	affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Baumann CA (2000), Baumann CA (2000), Kimura A (2001), Limpert AS (2007), Ding Y (2005)	6
FRS2	0	SORBS1	2	two hybrid, pull down, affinity chromatography technology	Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012)	3
CBL	7	YWHAB	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Robertson H (1997), Robertson H (1997), Robertson H (1997), Subramanian RR (2001), Chernock RD (2001), Brehme M (2009), Couzens AL (2013)	7
LATS2	1	SORBS1	2	bioid	Couzens AL (2013)	1
SORBS1	2	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin WH (2001), Fernow I (2009), Fernow I (2009)	3
KHDRBS1	1	SORBS1	2	unspecified method	Asbach B (2012)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
NCK2	2	SEMA6A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
INSR	9	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Onnockx S (2008)	2
FRS2	0	FLOT1	0	two hybrid, pull down, pull down, affinity chromatography technology	Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012)	4
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
TGS1	0	SORBS1	2	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	CBL	7	bioid	Guo Z (2014)	1
NCK2	2	AFDN	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SORBS1	2	SEMA6A	3	two hybrid, two hybrid	Nakayama M (2002), Nakayama M (2002)	2
FRS2	0	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wong A (2002), Wong A (2002), Belleudi F (2007)	3
LATS2	1	SRC	2	affinity chromatography technology	Si Y (2017)	1
SORBS1	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Vandenbroere I (2003), Limpert AS (2007)	4
CDK6	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NTRK1	1	SOS1	5	affinity chromatography technology	Emdal KB (2015)	1
KHDRBS1	1	CASP8	1	affinity chromatography technology	Ramakrishnan P (2011)	1
NTRK1	1	SH2B2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Qian X (1998), Emdal KB (2015)	3
EIF6	2	RPL4	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NCK2	2	SOS1	5	affinity chromatography technology	Braverman LE (1999)	1
SRC	2	SORBS1	2	enzymatic study	Fernow I (2009)	1
MAP4K3	1	SORBS1	2	two hybrid	Bandyopadhyay S (2010)	1
CDH1	4	NCK2	2	bioid	Guo Z (2014)	1
NTRK1	1	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1