PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP16	0	FBXO11	14	unspecified method	Hard RL (2010)	1
USP16	0	USP16	0	pull down	Xu Y (2013)	1
USP16	0	DBT	0	affinity chromatography technology	Sowa ME (2009)	1
ESR1	0	EXOSC10	1	affinity chromatography technology	Tarallo R (2011)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
USP16	0	HIST2H2AA3	0	enzymatic study	Joo HY (2007)	1
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
APOM	0	USP16	0	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	USP16	0	affinity chromatography technology	Okada M (2015)	1
USP16	0	H2AFZ	1	enzymatic study	Draker R (2011)	1
CALM1	0	USP16	0	pull down	Shen X (2005)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
CDK1	0	HIST1H2AB	0	enzymatic study	Chen M (2012)	1
USP16	0	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Zhang Z (2014), Zhang Z (2014), Huttlin EL (2017)	4
USP16	0	HIST1H2BB	3	enzymatic study	Xu Y (2013)	1
TTK	4	USP16	0	enzymatic study	Stratford JK (2017)	1
USP16	0	UBD	0	unspecified method	Hard RL (2010)	1
TXNL1	2	USP16	0	biochemical	Havugimana PC (2012)	1
USP16	0	UBC	7	unspecified method, enzymatic study, pull down, unspecified method, pull down, pull down	Pai MT (2007), Faesen AC (2011), Kovacs JJ (2004), Ernst A (2013), Zhang X (2017), Kwasna D (2018)	6
USP16	0	WDR54	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	SRPRB	0	pull down	Zhang X (2017)	1
UBC	7	TXNL1	2	affinity chromatography technology	Matsumoto M (2005)	1
CALM1	0	ESR1	0	pull down	Garcia Pedrero JM (2002)	1
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
CDK1	0	USP16	0	enzymatic study, enzymatic study	Xu Y (2013), Zhuo X (2015)	2
CALM1	0	HERC2	9	pull down	Shen X (2005)	1
XPO1	8	CSNK1D	3	affinity chromatography technology	Kirli K (2015)	1
CSNK1D	3	USP16	0	biochemical	Havugimana PC (2012)	1
CDK1	0	HIST1H2BB	3	enzymatic study	Chen M (2012)	1
RNF8	2	HIST2H2AC	1	enzymatic study, enzymatic study	Mattiroli F (2012), Paul A (2017)	2
UBC	7	PTOV1	3	pull down	Nathan JA (2013)	1
PLK1	0	USP16	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhuo X (2015), Zhuo X (2015), Zhuo X (2015), Zhuo X (2015)	4
USP16	0	NEURL4	3	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	USP16	0	affinity chromatography technology	Xu Y (2013)	1
HIST1H2AB	0	UBC	7	affinity chromatography technology	Sharma N (2013)	1
HERC2	9	NEURL4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Galligan JT (2015)	5
USP16	0	HIST4H4	1	unspecified method	Hard RL (2010)	1
USP16	0	HIST1H2BL	0	affinity chromatography technology	Sowa ME (2009)	1
ESR1	0	HIST2H2AC	1	pull down	Nalvarte I (2010)	1
SRPRB	0	USP16	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF8	2	USP16	0	affinity chromatography technology, affinity chromatography technology	Zhang Z (2014), Zhang Z (2014)	2
ESR1	0	TTK	4	affinity chromatography technology	Han SJ (2016)	1
HIST1H2AB	0	HIST1H2BB	3	pull down	Sato K (2012)	1
UBC	7	HIST2H2AA3	0	pull down	Zhang X (2017)	1
RNF8	2	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bekker-Jensen S (2010), Bekker-Jensen S (2010), Bekker-Jensen S (2010), Rendtlew Danielsen J (2012), Guerra-Rebollo M (2012), Zhang Z (2014)	6
UBC	7	H2AFZ	1	affinity chromatography technology	Matsumoto M (2005)	1
ALPPL2	3	USP16	0	affinity chromatography technology	Huttlin EL (2017)	1
USP16	0	HIST1H2AB	0	enzymatic study	Xu Y (2013)	1
XPO1	8	WDR54	0	affinity chromatography technology	Kirli K (2015)	1
IGF2BP3	0	USP16	0	biochemical	Havugimana PC (2012)	1
USP16	0	HIST2H2AC	1	enzymatic study, enzymatic study	Joo HY (2007), Draker R (2011)	2
UBC	7	CALM1	0	affinity chromatography technology	Bish RA (2007)	1
USP16	0	PTOV1	3	unspecified method	Hard RL (2010)	1
EXOSC10	1	USP16	0	two hybrid	Lehner B (2004)	1
UBC	7	IGF2BP3	0	affinity chromatography technology	Matsumoto M (2005)	1