PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KPNB1	3	TRIM3	2	affinity chromatography technology, affinity chromatography technology	Mukherjee S (2016), Mukherjee S (2016)	2
CUL3	17	KPNB1	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE2E1	1	CUL3	17	pull down	Plafker KS (2009)	1
CUL3	17	TRIM3	2	affinity chromatography technology	Wimuttisuk W (2014)	1
NOTCH1	25	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Mukherjee S (2016)	2
TRIM3	2	PDHA1	7	biochemical	Wan C (2015)	1
TRIM3	2	UBE2D1	0	pull down	Raheja R (2014)	1
HGS	5	NOTCH1	25	affinity chromatography technology	Sjoeqvist M (2014)	1
KRAS	1	UBE2D1	0	genetic interference	Luo J (2009)	1
UBE2D2	0	TRIM2	1	two hybrid	Markson G (2009)	1
KRAS	1	TEAD2	2	genetic interference	Luo J (2009)	1
CUL3	17	KPNA4	0	affinity chromatography technology	Bennett EJ (2010)	1
HGS	5	MYO5A	17	affinity chromatography technology	Yan Q (2005)	1
CDKN1A	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
CSNK1E	0	TRIM3	2	affinity chromatography technology	Hein MY (2015)	1
PDHA1	7	ACTN4	4	affinity chromatography technology	Malty RH (2017)	1
TRIM3	2	CDKN1A	1	enzymatic study	Raheja R (2014)	1
UBE2D4	0	TRIM2	1	two hybrid	Markson G (2009)	1
TRIM3	2	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
TRIM3	2	TRIM3	2	two hybrid	Reymond A (2001)	1
TEAD2	2	TRIM3	2	affinity chromatography technology	Li X (2015)	1
TRIM3	2	NOTCH1	25	affinity chromatography technology	Mukherjee S (2016)	1
TRIM3	2	MYO5A	17	affinity chromatography technology	Yan Q (2005)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
TRIM2	1	PDHA1	7	biochemical	Wan C (2015)	1
KIF21B	2	TRIM3	2	affinity chromatography technology, two hybrid	Labonte D (2013), Labonte D (2013)	2
KPNA4	0	KPNB1	3	pull down, affinity chromatography technology, affinity chromatography technology	Koehler M (1999), Hein MY (2015), Mukherjee S (2016)	3
TRIM3	2	UBE2E1	1	pull down	Raheja R (2014)	1
PDHA1	7	KPNB1	3	affinity chromatography technology	Malty RH (2017)	1
UBE2E1	1	TRIM2	1	two hybrid	Markson G (2009)	1
NOTCH1	25	CUL3	17	affinity chromatography technology, affinity chromatography technology	Ren K (2014), Ren K (2014)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HGS	5	ACTN4	4	two hybrid, affinity chromatography technology, biochemical, imaging technique	Yan Q (2005), Yan Q (2005), Kristensen AR (2012), Veettil MV (2016)	4
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
TRIM3	2	ACTN4	4	two hybrid, affinity chromatography technology, affinity chromatography technology	El-Husseini AE (2000), El-Husseini AE (2000), Yan Q (2005)	3
CUL3	17	PDHA1	7	affinity chromatography technology	Bennett EJ (2010)	1
UBE2U	0	TRIM2	1	two hybrid	van Wijk SJ (2009)	1
TNFAIP3	3	TRIM3	2	two hybrid	Hayes SD (2012)	1
TRIM2	1	TRIM3	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFAIP3	3	TRIM2	1	two hybrid	Hayes SD (2012)	1
HECW2	13	TRIM3	2	affinity chromatography technology	Lu L (2013)	1
UBE2G2	0	TRIM3	2	two hybrid	van Wijk SJ (2009)	1
UBE2D2	0	CUL3	17	pull down	Plafker KS (2009)	1
TRIM3	2	KPNA4	0	affinity chromatography technology	Mukherjee S (2016)	1
UBE2U	0	TRIM3	2	two hybrid	van Wijk SJ (2009)	1
KRAS	1	TRIM3	2	genetic interference	Luo J (2009)	1
TRIM3	2	UBE2D2	0	pull down	Raheja R (2014)	1
HGS	5	TRIM3	2	affinity chromatography technology	Yan Q (2005)	1
UBE2D1	0	TRIM2	1	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2