PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	UBE2N	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Joch M (2007), Olzmann JA (2007), Chaugule VK (2011), Sha D (2010), Lim GG (2013), Durcan TM (2011), McKeon JE (2014), Sha D (2010)	8
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
UBE2K	0	UHRF2	1	two hybrid	Markson G (2009)	1
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
UBE2K	0	MKRN2	2	two hybrid	Markson G (2009)	1
RNF181	0	UBE2N	1	pull down	Pedersen SM (2015)	1
SMURF1	4	UBE2D1	0	pull down, enzymatic study	Kristariyanto YA (2015), Andrews PS (2010)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
UBE2G1	2	APP	1	pull down	Olah J (2011)	1
TLR3	2	TAB2	5	affinity chromatography technology	Jiang Z (2003)	1
USP2	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
TRIM25	5	RABGEF1	1	affinity chromatography technology	Choudhury NR (2017)	1
RBCK1	0	PML	7	imaging technique	Tatematsu K (2005)	1
UBE2U	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
RBCK1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Donley C (2013), Donley C (2013)	6
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
LTBR	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
UBE2U	0	TRIM65	1	two hybrid	van Wijk SJ (2009)	1
MAP3K1	4	UBE2K	0	enzymatic study	Charlaftis N (2014)	1
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
TAB3	1	UBC	7	x-ray crystallography, pull down, pull down, pull down	Sato Y (2009), Kanayama A (2004), Wang J (2015), Zhang X (2017)	4
UBC	7	NAA10	9	pull down	Zhang X (2017)	1
PRKCA	7	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
RBCK1	0	TAB3	1	affinity chromatography technology	Tian Y (2007)	1
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
ARNT2	5	APP	1	pull down	Olah J (2011)	1
SHARPIN	1	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Elliott PR (2014), Draber P (2015), Elliott PR (2016)	4
OTUB2	0	TRIM25	5	two hybrid	Hayes SD (2012)	1
HSP90AA1	7	TAB2	5	affinity chromatography technology	Gano JJ (2010)	1
IKBKG	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Henn IH (2007), Henn IH (2007), Sha D (2010)	3
PDLIM7	0	SHARPIN	1	affinity chromatography technology	Wang L (2017)	1
TRAF1	0	SYCE1	0	two hybrid	Rolland T (2014)	1
ESR1	0	TRAF6	0	affinity chromatography technology	Robinson LJ (2009)	1
RBCK1	0	NR2C2	0	affinity chromatography technology	Tian Y (2007)	1
RABGEF1	1	SHARPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	MKRN2	2	two hybrid	Rolland T (2014)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
TLR3	2	SHARPIN	1	affinity chromatography technology	Zinngrebe J (2016)	1
UBE2D1	0	RNF181	0	two hybrid, pull down, pull down	van Wijk SJ (2009), Brophy TM (2008), Pedersen SM (2015)	3
LMO2	2	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ARPC5	2	affinity chromatography technology	Choudhury NR (2017)	1
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
MAP3K1	4	PSMD4	1	enzymatic study	Charlaftis N (2014)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D4	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
HSP90AA1	7	TSSK3	3	affinity chromatography technology	Taipale M (2012)	1
NOD2	1	TNFAIP3	3	affinity chromatography technology	Draber P (2015)	1
SMURF1	4	PSMD4	1	enzymatic study	Andrews PS (2010)	1
OTULIN	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rivkin E (2013), Schaeffer V (2014), Elliott PR (2014), Draber P (2015)	4
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
UBE2L3	1	RBCK1	0	two hybrid, pull down, pull down	Markson G (2009), Tatematsu K (2008), Kirisako T (2006)	3
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
NR2C2	0	TRAF6	0	affinity chromatography technology	Rafferty BJ (2010)	1
RBCK1	0	IREB2	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid	Yamanaka K (2003), Yamanaka K (2003), Zumbrennen KB (2008), Zumbrennen KB (2008), Yamanaka K (2003)	5
USP7	14	RBCK1	0	two hybrid	Hayes SD (2012)	1
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
ESR1	0	FKBPL	1	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
PRKN	1	UBE2S	2	pull down	Kazlauskaite A (2014)	1
HSP90AA1	7	NR1I2	5	affinity chromatography technology	Taipale M (2012)	1
RNF31	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2014), Zhu J (2014)	2
IKBKG	0	PRKCB	4	pull down	Fenner BJ (2010)	1
RNF31	3	PDLIM7	0	affinity chromatography technology, affinity chromatography technology	Wang L (2017), Wang L (2017)	2
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
USP15	4	UBE2S	2	enzymatic study	Bremm A (2010)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
NOD2	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
OTUB2	0	APP	1	pull down	Olah J (2011)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
MALT1	1	TNFAIP3	3	affinity chromatography technology	Yang Y (2014)	1
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
UBE2D3	1	UHRF2	1	two hybrid, affinity chromatography technology	van Wijk SJ (2009), Lai M (2016)	2
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
RNF181	0	UBC	7	enzymatic study	Pedersen SM (2015)	1
PCGF2	3	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010)	3
USP7	14	UBE2S	2	enzymatic study	Bremm A (2010)	1
UBE2D4	0	TRIM25	5	two hybrid	Markson G (2009)	1
UBE2U	0	PCGF2	3	two hybrid	van Wijk SJ (2009)	1
FKBPL	1	UBC	7	affinity chromatography technology	Donley C (2013)	1
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
TRIM25	5	NAA10	9	affinity chromatography technology	Choudhury NR (2017)	1
ARNT2	5	SYCE1	0	two hybrid	Corominas R (2014)	1
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
BIRC3	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
TRIM21	0	RBCK1	0	two hybrid	Woodsmith J (2012)	1
RBCK1	0	PCGF2	3	two hybrid	Woodsmith J (2012)	1
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
SMURF1	4	UBE2K	0	enzymatic study	Andrews PS (2010)	1
USP21	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
LMO2	2	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
RBCK1	0	APP	1	pull down	Olah J (2011)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
USP21	2	DDX58	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Fan Y (2014), Fan Y (2014), Fan Y (2014)	3
MALT1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
ESR1	0	NR2C2	0	pull down, pull down	Shyr CR (2002), Shyr CR (2002)	2
UBE2S	2	RBCK1	0	two hybrid	Markson G (2009)	1
UBC	7	USP32	0	pull down, pull down	Zhang X (2017), Kwasna D (2018)	2
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
TRIM25	5	NR2C2	0	affinity chromatography technology	Choudhury NR (2017)	1
RBCK1	0	TRIM65	1	two hybrid	Woodsmith J (2012)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
MAP3K1	4	RBCK1	0	enzymatic study	Charlaftis N (2014)	1
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
UBE2D3	1	DDX58	3	enzymatic study	Arimoto K (2008)	1
ARNT2	5	RBCK1	0	two hybrid	Corominas R (2014)	1
USP21	2	USP7	14	enzymatic study	Loch CM (2012)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
LTBR	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
PRKN	1	UBE2G1	2	affinity chromatography technology, pull down, pull down, pull down	Imai Y (2001), Kalia SK (2004), Fallon L (2006), Durcan TM (2011)	4
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
LDLRAD4	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMD4	1	APP	1	pull down	Olah J (2011)	1
SHARPIN	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Verhelst K (2012), Verhelst K (2012)	2
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
PRKN	1	UBE2L3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down	Shimura H (2001), Imai Y (2000), Ramsey CP (2010), Sato S (2006), Chaugule VK (2011), Um JW (2012), Choi P (2003), Uchiki T (2009), Joch M (2007), Li Y (2011), Shin JH (2011), Chung KK (2001), Sato S (2006), Hampe C (2006), Um JW (2006), Chaugule VK (2011), Wang H (2011), Imam SZ (2011), Duda DM (2013), Wauer T (2013), Rankin CA (2014), Shimura H (2000), Durcan TM (2011), Wenzel DM (2011), Romani-Aumedes J (2014), Caulfield TR (2014), Koyano F (2014), Kurup PK (2015), Wauer T (2015), Song P (2016), Kumar A (2015), Lee SB (2015), Lee SB (2015), Song P (2016), Kazlauskaite A (2015), Veeriah S (2010), Park S (2017), Park S (2017), Kumar A (2017), Klosowiak JL (2016), Gersch M (2017), Tang MY (2017), Kazlauskaite A (2014), Sul JW (2013)	44
TRIM25	5	USP32	0	affinity chromatography technology	Choudhury NR (2017)	1
UCHL5	1	APP	1	pull down	Olah J (2011)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
IREB2	3	APP	1	pull down	Olah J (2011)	1
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
PDLIM7	0	NR2C2	0	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
FKBPL	1	APP	1	pull down	Olah J (2011)	1
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
TAB3	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology	Ishitani T (2003), Kanayama A (2004), Shinohara H (2016)	3
TNF	0	OTULIN	0	affinity chromatography technology	Schaeffer V (2014)	1
PRKN	1	BACH1	3	affinity chromatography technology	Zenke-Kawasaki Y (2007)	1
NOD2	1	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
NOD2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
UBE2D4	0	UHRF2	1	two hybrid	van Wijk SJ (2009)	1
RNF31	3	PRKCA	7	enzymatic study	Queisser MA (2014)	1
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBE2U	0	RBCK1	0	two hybrid	Markson G (2009)	1
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
MALT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li Y (2013), Li Y (2013), Ginster S (2017)	3
TRAF1	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017), Abdul-Sater AA (2017)	4
SHARPIN	1	ESR1	0	affinity chromatography technology	Zhuang T (2017)	1
MALT1	1	UBE2N	1	pull down	Zhou H (2004)	1
LDLRAD4	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
PAN2	3	HSP90AA1	7	affinity chromatography technology	Bett JS (2013)	1
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
DDX58	3	UBC	7	pull down, pull down	Feng M (2012), Zeng W (2010)	2
UBE2S	2	UBE2D3	1	affinity chromatography technology	Kuang P (2016)	1
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
USP32	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
PDLIM7	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
USP7	14	UHRF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Liu Y (2016), Lai M (2016)	3
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
BACH1	3	RBCK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zenke-Kawasaki Y (2007), Zenke-Kawasaki Y (2007), Zenke-Kawasaki Y (2007)	3
UBE2L6	0	RBCK1	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TNF	0	MAP3K7	2	affinity chromatography technology	Ea CK (2006)	1
MKRN2	2	UBE2D4	0	two hybrid	Rolland T (2014)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
TRIM25	5	TNFRSF1A	3	affinity chromatography technology	Choudhury NR (2017)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	UBE2L3	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2G1	2	RBCK1	0	two hybrid	Markson G (2009)	1
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
UBE2L6	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
UBE2D3	1	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
RNF31	3	UBE2L3	1	pull down, pull down, pull down	Kirisako T (2006), Greenfeld H (2015), Liu J (2017)	3
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
MALT1	1	TAB2	5	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
NEDD4	2	RBCK1	0	pull down	Persaud A (2009)	1
TLR3	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Cusson-Hermance N (2005)	2
SMURF1	4	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Ito I (2010), Ito I (2010), Ito I (2010)	3
USP21	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
RBCK1	0	UHRF2	1	two hybrid	Woodsmith J (2012)	1
RBCK1	0	MKRN2	2	two hybrid	Woodsmith J (2012)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
ARPC5	2	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
TLR3	2	BIRC3	1	affinity chromatography technology	Zinngrebe J (2016)	1
PAN2	3	TRIM21	0	affinity chromatography technology	Bett JS (2013)	1
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
RBCK1	0	MAP3K7	2	affinity chromatography technology	Tian Y (2007)	1
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
USP21	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Xu G (2010), Xu G (2010)	2
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
UBE2D4	0	RBCK1	0	two hybrid	Markson G (2009)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
IKBKG	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Verhelst K (2012), Zak DE (2011), Tokunaga F (2011), Tokunaga F (2011), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017), Bal E (2017)	10
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RNF31	3	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Rivkin E (2013), Rivkin E (2013), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Schimmack G (2017)	20
BIRC3	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
DDX58	3	RBCK1	0	affinity chromatography technology	Inn KS (2011)	1
UBC	7	UCHL5	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, pull down, pull down, enzymatic study, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Boudreaux D (2012), Sahtoe DD (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	10
TRAF6	0	APP	1	pull down	Olah J (2011)	1
LTBR	0	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Huttlin EL (2015), Huttlin EL (2017)	3
PRKCB	4	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
SMURF1	4	RBCK1	0	enzymatic study	Andrews PS (2010)	1
USP49	1	RBCK1	0	two hybrid	Hayes SD (2012)	1
PRKCB	4	RBCK1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tatematsu K (2008), Vallentin A (2007), Vallentin A (2007), Nakamura M (2006), Gustafsson Sheppard N (2012)	5
UBE2K	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
NOD2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Kim JY (2008), Chen CM (2004), Chen CM (2004), Chen CM (2004), Chen CM (2004), Windheim M (2007)	6
ESR1	0	TAB3	1	affinity chromatography technology	Okada M (2015)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
TNF	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
OTUD6A	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM25	5	DDX58	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gack MU (2007), Gack MU (2007), Gack MU (2007), Gack MU (2010), Nistal-Villan E (2010), Nistal-Villan E (2010), Inn KS (2011), Inn KS (2011), Maharaj NP (2011), Oshiumi H (2013), Weng L (2014), Xia ZP (2009), Feng M (2012), Gao D (2009), Gao D (2009), Jiang J (2016), Hu Y (2017), Hu Y (2017)	18
TAB2	5	NR2C2	0	affinity chromatography technology, affinity chromatography technology	Suzuki S (2007), Rafferty BJ (2010)	2
TRIM25	5	UBE2S	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
UBE2D2	0	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
USP15	4	TRIM21	0	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
RABGEF1	1	UBE2D1	0	pull down	Kalesnikoff J (2007)	1
PRKCA	7	RBCK1	0	affinity chromatography technology, enzymatic study	Queisser MA (2014), Queisser MA (2014)	2
UBE2D3	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
PDLIM7	0	RBCK1	0	affinity chromatography technology	Wang L (2017)	1
UBE2L3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Bruce MC (2008), Wiesner S (2007), Vina-Vilaseca A (2010), Anindya R (2007), Lin Q (2010), Chung S (2011), Tofaris GK (2011), Han L (2013), Persaud A (2014), Uchiki T (2009), Miyazaki K (2003), Zhang W (2016), Zhang X (2017)	14
SHARPIN	1	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Nakazawa S (2016)	2
FKBPL	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
NEDD4	2	PSMD4	1	enzymatic study, enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012), Puig-Sarries P (2015)	3
UCHL5	1	PSMD4	1	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Qiu XB (2006), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	6
BIRC3	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
RABGEF1	1	ESR1	0	affinity chromatography technology	La Rosa P (2011)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
USP21	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
USP7	14	TRAF1	0	pull down	Zapata JM (2001)	1
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
HSP90AA1	7	NR2C2	0	affinity chromatography technology	Taipale M (2012)	1
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
NOD2	1	IKBKG	0	affinity chromatography technology	Damgaard RB (2012)	1
PAN2	3	RBCK1	0	two hybrid	Hayes SD (2012)	1
OTUD6A	2	UBC	7	enzymatic study	Mevissen TE (2013)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
TNFRSF1A	3	RABGEF1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
RBCK1	0	RNF181	0	two hybrid	Woodsmith J (2012)	1
LMO2	2	SHARPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
PDLIM7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
MAP3K7	2	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011), Mendoza H (2008), Criollo A (2011), Hong S (2007), Minoda Y (2009), Liu R (2014), Shinohara H (2016), Zhang J (2017)	13
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
UBE2S	2	APP	1	pull down	Olah J (2011)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
OTUB2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
NEDD4	2	PDLIM7	0	affinity chromatography technology	DCruz R (2016)	1
NAA10	9	RBCK1	0	two hybrid	Rolland T (2014)	1
TAB2	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Cutrupi S (2012), Cutrupi S (2012), Zhu P (2006), Zhu P (2006), Reineri S (2016), Reineri S (2016), Reineri S (2016), Reineri S (2016)	8
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
NR1I2	5	RBCK1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rana R (2013), Rana R (2013), Rana R (2013), Rana R (2013)	4
HSP90AA1	7	PRKCA	7	affinity chromatography technology	Taipale M (2012)	1
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
USP7	14	ARNT2	5	two hybrid	Lim J (2006)	1
FKBPL	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jascur T (2005), Jascur T (2005), Donley C (2013), Donley C (2013), Taipale M (2014), Taipale M (2014)	6
UHRF2	1	UBE2D1	0	pull down, pull down	Mori T (2011), Mori T (2004)	2
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
OTUB2	0	TRAF6	0	affinity chromatography technology, two hybrid	Li S (2010), Hayes SD (2012)	2
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
UBE2U	0	PML	7	two hybrid	van Wijk SJ (2009)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
UBE2D2	0	UHRF2	1	two hybrid	van Wijk SJ (2009)	1
DDX58	3	USP15	4	affinity chromatography technology, pull down	Zhang H (2015), Zhang H (2015)	2
PDLIM7	0	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down	Sangadala S (2006), Sangadala S (2006), Sangadala S (2006), Sangadala S (2006), Sangadala S (2007), Sangadala S (2007)	6
UBE2L6	0	TRIM25	5	affinity chromatography technology	Urano T (2002)	1
SMURF1	4	PRKCA	7	enzymatic study	Andrews PS (2010)	1
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
TRIM21	0	UBE2L3	1	pull down	Wada K (2006)	1
TAB2	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SMURF1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Nie J (2010), Nie J (2010), Fei C (2013), Wang J (2013), Cao Y (2014), Xie P (2014), Xie P (2014), Lu K (2008), Kristariyanto YA (2015), Andrews PS (2010), He S (2017), Zhang Y (2017)	12
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
HSP90AA1	7	PRKCB	4	affinity chromatography technology	Taipale M (2012)	1
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
TLR3	2	RNF31	3	affinity chromatography technology	Zinngrebe J (2016)	1
SMURF1	4	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Cao Y (2014), Xie P (2014), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Andrews PS (2010), He S (2017), Zhang Y (2017)	8
USP2	0	TRIM21	0	two hybrid	Hayes SD (2012)	1
TRIML1	2	APP	1	pull down	Olah J (2011)	1
PRKCB	4	RNF31	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), Nakamura M (2006)	3
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRIM25	5	LTBR	0	affinity chromatography technology	Choudhury NR (2017)	1
PSMD4	1	RBCK1	0	affinity chromatography technology, pull down	Yoshimoto N (2009), Beasley SA (2012)	2
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
RABGEF1	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
LTBR	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	UBE2G1	2	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	UBE2K	0	pull down	Kazlauskaite A (2014)	1
FKBPL	1	RBCK1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013), Donley C (2013), Huttlin EL (2017)	4
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
UBE2K	0	RBCK1	0	two hybrid	Markson G (2009)	1
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
RBCK1	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Tian Y (2007), Tian Y (2007)	2
RBCK1	0	TRIML1	2	two hybrid	Woodsmith J (2012)	1
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
RBCK1	0	TSSK3	3	two hybrid	Rolland T (2014)	1
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
ARNT2	5	TRAF1	0	two hybrid	Corominas R (2014)	1
UBE2D4	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
MALT1	1	RBCK1	0	enzymatic study	Klein T (2015)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
UBE2D1	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
RABGEF1	1	UBE2D3	1	pull down	Xu L (2010)	1
TAB3	1	IKBKG	0	pull down, pull down	Kanayama A (2004), Emmerich CH (2013)	2
PSMD4	1	PRKN	1	pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Safadi SS (2010), Uchiki T (2009), Sakata E (2003), Safadi SS (2011), Um JW (2010), Um JW (2010), Kim HT (2012), Beasley SA (2012), Sarraf SA (2013), Sarraf SA (2013)	10
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
LTBR	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
MALT1	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
LDLRAD4	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K1	4	UCHL5	1	enzymatic study	Charlaftis N (2014)	1
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RBCK1	0	RBCK1	0	enzymatic study, affinity chromatography technology, two hybrid	Tatematsu K (2008), Yoshimoto N (2005), Rolland T (2014)	3
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
TRIM25	5	PML	7	affinity chromatography technology	Choudhury NR (2017)	1
OTULIN	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Keusekotten K (2013), Keusekotten K (2013), Rivkin E (2013), Schaeffer V (2014), Mevissen TE (2013), Wauer T (2015), Kliza K (2017), Kwasna D (2018)	8
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
PRKN	1	UBE2L6	0	affinity chromatography technology, affinity chromatography technology, pull down	Zhang Y (2000), Um JW (2012), Chaugule VK (2011)	3
PCGF2	3	UBE2D3	1	pull down	Taherbhoy AM (2015)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
USP7	14	PML	7	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Sivachandran N (2010), Sarkari F (2011), Sarkari F (2011), Hein MY (2015)	4
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
RABGEF1	1	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
RBCK1	0	SYCE1	0	two hybrid	Rolland T (2014)	1
OTUB2	0	UBE2N	1	pull down	Nakada S (2010)	1
SMURF1	4	UBE2G1	2	enzymatic study	Andrews PS (2010)	1
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
TLR3	2	RBCK1	0	affinity chromatography technology	Zinngrebe J (2016)	1
RBCK1	0	NDUFAF3	2	two hybrid	Rolland T (2014)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
TNFRSF1A	3	PRKCB	4	affinity chromatography technology	Kilpatrick LE (2000)	1
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
MAP3K1	4	UBE2G1	2	enzymatic study	Charlaftis N (2014)	1
PRKN	1	UBE2D4	0	pull down	Kazlauskaite A (2014)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
LDLRAD4	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UCHL5	1	RBCK1	0	two hybrid	Hayes SD (2012)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2