PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NANOG	0	ARID3B	4	affinity chromatography technology	Oliviero G (2015)	1
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
1820	0	ARID3B	4	affinity chromatography technology	Huttlin EL (2017)	1
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
JUN	0	ARID3B	4	affinity chromatography technology	Li X (2015)	1
NANOG	0	TEAD2	2	affinity chromatography technology	Oliviero G (2015)	1
FOXL1	0	1820	0	affinity chromatography technology	Li X (2015)	1
POT1	2	ARID3B	4	two hybrid	Lee OH (2011)	1
RB1	2	AR	3	pull down, pull down, two hybrid, affinity chromatography technology	Lu J (1998), Yeh S (1998), Yeh S (1998), Gamble SC (2007)	4
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
FOXL1	0	ARID3B	4	affinity chromatography technology	Li X (2015)	1
NR3C1	2	ARID3B	4	bioid	Lempiaeinen JK (2017)	1
PPP3CC	0	APP	1	pull down	Olah J (2011)	1
HELZ	6	1820	0	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	1820	0	affinity chromatography technology	Cox JL (2013)	1
HELZ	6	RB1	2	affinity chromatography technology	Boldt K (2016)	1
HELZ	6	ARID3B	4	affinity chromatography technology	Boldt K (2016)	1
PPP3CC	0	ARID3B	4	affinity chromatography technology	Huttlin EL (2015)	1
FOXL1	0	NR3C1	2	affinity chromatography technology	Li X (2015)	1
FOXH1	1	ARID3B	4	affinity chromatography technology	Li X (2015)	1
RB1	2	ARID3B	4	pull down	Numata S (1999)	1
SOX2	4	MEPCE	1	affinity chromatography technology	Cox JL (2013)	1
MARF1	8	ARID3B	4	affinity chromatography technology	Boldt K (2016)	1
FOXB1	1	1820	0	affinity chromatography technology	Li X (2015)	1
MEPCE	1	ARID3B	4	affinity chromatography technology	Jeronimo C (2007)	1
BCAT1	6	HELZ	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LHX6	1	ARID3B	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TINF2	1	ARID3B	4	two hybrid	Lee OH (2011)	1
RB1	2	CDK9	3	pull down, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, enzymatic study	Simone C (2002), Simone C (2002), De Luca A (1997), Garriga J (1996), Garriga J (1996), Grana X (1994)	6
AR	3	ARID3B	4	bioid	Lempiaeinen JK (2017)	1
HELZ	6	MARF1	8	affinity chromatography technology	Boldt K (2016)	1
ARID3B	4	APP	1	pull down	Olah J (2011)	1
MARF1	8	RB1	2	affinity chromatography technology	Boldt K (2016)	1
RBPJ	1	ARID3B	4	affinity chromatography technology	Li X (2015)	1
MEPCE	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	7
RBPJ	1	APP	1	pull down	Olah J (2011)	1
BCAT1	6	ARID3B	4	affinity chromatography technology	Huttlin EL (2015)	1
FOXH1	1	1820	0	affinity chromatography technology	Li X (2015)	1
FOXL1	0	IRF9	0	affinity chromatography technology	Li X (2015)	1
1820	0	APP	1	pull down	Olah J (2011)	1
JUN	0	RB1	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Nishitani J (1999), Nishitani J (1999), Nishitani J (1999), Nead MA (1998), Nead MA (1998)	5
TEAD2	2	ARID3B	4	affinity chromatography technology	Li X (2015)	1
NANOG	0	SOX2	4	affinity chromatography technology	Oliviero G (2015)	1
CDK9	3	ARID3B	4	affinity chromatography technology	Jeronimo C (2007)	1
NANOG	0	1820	0	affinity chromatography technology	Oliviero G (2015)	1
FOXE1	2	ARID3B	4	affinity chromatography technology	Li X (2015)	1
MARF1	8	1820	0	affinity chromatography technology	Boldt K (2016)	1
JUN	0	AR	3	affinity chromatography technology, affinity chromatography technology	Sato N (1997), Sato N (1997)	2
IRF9	0	ARID3B	4	two hybrid	Ravasi T (2010)	1
TEAD2	2	NR3C1	2	affinity chromatography technology	Li X (2015)	1
SOX2	4	ARID3B	4	affinity chromatography technology	Cox JL (2013)	1
CDK9	3	AR	3	affinity chromatography technology, pull down	Lee DK (2001), Lee DK (2001)	2
FOXB1	1	ARID3B	4	affinity chromatography technology	Li X (2015)	1
NEUROG3	3	ARID3B	4	affinity chromatography technology	Huttlin EL (2017)	1