PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM16	0	TOMM34	0	biochemical	Kristensen AR (2012)	1
TRIM16	0	391634	0	biochemical	Kristensen AR (2012)	1
ULK1	8	TRIM16	0	enzymatic study, affinity chromatography technology	Chauhan S (2016), Chauhan S (2016)	2
POT1	2	TRIM16	0	two hybrid	Lee OH (2011)	1
NXF1	0	CUL5	1	affinity chromatography technology	Castello A (2012)	1
LGALS3	0	VIM	0	affinity chromatography technology	Carvalho RS (2014)	1
MOV10	6	ATG16L1	1	affinity chromatography technology	Castello A (2012)	1
TERF1	1	TOMM34	0	two hybrid	Lee OH (2011)	1
TRIM16	0	TRIM16L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM16	0	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Chauhan S (2016), Chauhan S (2016)	2
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
TERF1	1	391634	0	affinity chromatography technology	Giannone RJ (2010)	1
NXF1	0	DEPTOR	1	affinity chromatography technology	Castello A (2012)	1
ACD	1	TOMM34	0	two hybrid	Lee OH (2011)	1
TRIM16	0	CLUH	8	biochemical	Kristensen AR (2012)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
TOMM34	0	391634	0	biochemical	Kristensen AR (2012)	1
ULK1	8	BECN1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bodemann BO (2011), Chauhan S (2015), Chauhan S (2016)	3
ATG16L1	1	ULK1	8	affinity chromatography technology	Gammoh N (2013)	1
LGALS3	0	APP	1	pull down	Olah J (2011)	1
NXF1	0	E2F1	0	affinity chromatography technology	Castello A (2012)	1
LGALS3	0	RRAGB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACD	1	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
TRIM16	0	BECN1	2	affinity chromatography technology	Chauhan S (2016)	1
CUL5	1	MCM7	5	affinity chromatography technology	Bennett EJ (2010)	1
TRIM16	0	MCM7	5	biochemical	Kristensen AR (2012)	1
LGALS2	0	TRIM16	0	affinity chromatography technology	Chauhan S (2016)	1
ACD	1	TRIM16	0	two hybrid	Lee OH (2011)	1
MCM7	5	CLUH	8	biochemical	Kristensen AR (2012)	1
TRIM16	0	TFEB	6	affinity chromatography technology, affinity chromatography technology	Chauhan S (2016), Chauhan S (2016)	2
CLUH	8	391634	0	biochemical	Kristensen AR (2012)	1
LGALS2	0	APP	1	pull down	Olah J (2011)	1
TRIM16	0	CUL4A	2	affinity chromatography technology	Chauhan S (2016)	1
RRAGB	1	RRAGD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sancak Y (2008), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010)	6
TERF1	1	MCM7	5	affinity chromatography technology	Giannone RJ (2010)	1
MOV10	6	TOMM34	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	ATG16L1	1	affinity chromatography technology	Castello A (2012)	1
TRIM16	0	PPP3CB	1	affinity chromatography technology	Chauhan S (2016)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
TRIM16	0	CUL5	1	affinity chromatography technology	Chauhan S (2016)	1
TINF2	1	TOMM34	0	two hybrid	Lee OH (2011)	1
TRIM16	0	DEPTOR	1	affinity chromatography technology	Chauhan S (2016)	1
MCM7	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NXF1	0	TOMM34	0	affinity chromatography technology	Castello A (2012)	1
TRIM16	0	APP	1	pull down	Olah J (2011)	1
TRIM16	0	RRAGD	1	affinity chromatography technology	Chauhan S (2016)	1
NXF1	0	391634	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	MCM7	5	affinity chromatography technology	Castello A (2012)	1
VIM	0	TRIM16	0	affinity chromatography technology	Marshall GM (2010)	1
TRIM16	0	E2F1	0	affinity chromatography technology	Marshall GM (2010)	1
MOV10	6	TRIM16	0	affinity chromatography technology	Castello A (2012)	1
TINF2	1	TRIM16	0	two hybrid	Lee OH (2011)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
TRIM16	0	RRAGB	1	affinity chromatography technology	Chauhan S (2016)	1
NXF1	0	TRIM16	0	affinity chromatography technology	Castello A (2012)	1
POT1	2	TOMM34	0	two hybrid	Lee OH (2011)	1
DEPTOR	1	APP	1	pull down	Olah J (2011)	1
MOV10	6	E2F1	0	affinity chromatography technology	Castello A (2012)	1
LGALS3	0	TRIM16	0	affinity chromatography technology, affinity chromatography technology	Chauhan S (2016), Chauhan S (2016)	2
MCM7	5	TOMM34	0	biochemical	Kristensen AR (2012)	1
ATG16L1	1	APP	1	pull down	Olah J (2011)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
TRIM16	0	OPTN	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL5	1	ACD	1	affinity chromatography technology	Bennett EJ (2010)	1
OPTN	1	ATG16L1	1	affinity chromatography technology, pull down	Bansal M (2018), Bansal M (2018)	2
VIM	0	APP	1	pull down	Olah J (2011)	1
TERF1	1	TRIM16	0	two hybrid	Lee OH (2011)	1
CUL5	1	DEPTOR	1	enzymatic study	Antonioli M (2014)	1
RRAGB	1	APP	1	pull down	Olah J (2011)	1