PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DOK5	0	RAI2	0	two hybrid	Grossmann A (2015)	1
UBQLN4	2	RAI2	0	two hybrid	Lim J (2006)	1
CTBP2	7	RAI2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RAI2	0	APP	1	pull down	Olah J (2011)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
RAI2	0	SGTB	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
FHL2	0	APP	1	pull down	Olah J (2011)	1
APPL2	4	RAI2	0	two hybrid	Grossmann A (2015)	1
CTBP2	7	APP	1	pull down	Olah J (2011)	1
ATXN1	2	FHL2	0	two hybrid	Lim J (2006)	1
FHL2	0	RAI2	0	two hybrid	Rolland T (2014)	1
ATXN1	2	RAI2	0	two hybrid	Suter B (2013)	1
CTBP1	2	RAI2	0	two hybrid	Corominas R (2014)	1
ATXN1	2	UBQLN4	2	two hybrid, two hybrid	Davidson JD (2000), Lim J (2006)	2