PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BIRC2	1	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
TRIM25	5	MAP3K2	1	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	STK38	0	affinity chromatography technology	Taipale M (2012)	1
CTNNB1	30	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CH (2012), Chen CH (2012), Tian Q (2004), Tian Q (2004), Tian Q (2004), Fang D (2007)	6
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
MAPK7	1	YWHAG	5	affinity chromatography technology	Erazo T (2013)	1
GSK3B	1	BIRC2	1	affinity chromatography technology	Sun M (2009)	1
YWHAZ	1	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
AXIN1	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	AXIN1	1	affinity chromatography technology	Choudhury NR (2017)	1
MAPK7	1	SH2D2A	2	two hybrid	Wang J (2011)	1
TRIM25	5	SFN	1	affinity chromatography technology	Urano T (2002)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
YWHAE	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	MAP3K2	1	enzymatic study	Persaud A (2009)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
MAP3K2	1	TRAF7	11	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	CBY1	3	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K2	1	MAP2K3	1	enzymatic study	Deacon K (1997)	1
MAPK7	1	YWHAE	0	two hybrid, affinity chromatography technology	Zheng Q (2004), Erazo T (2013)	2
MAPK8	3	YWHAZ	1	enzymatic study	Yoshida K (2005)	1
BTRC	1	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
MAPK7	1	YWHAB	1	pull down, affinity chromatography technology	Zheng Q (2004), Zheng Q (2004)	2
MAP3K2	1	MAP2K7	5	affinity chromatography technology, biochemical, enzymatic study	Cheng J (2000), Cheng J (2000), Takeda AN (2014)	3
NEDD4L	3	MAP3K3	3	enzymatic study	Persaud A (2009)	1
NEDD4	2	MAP3K2	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
MAP2K5	1	TRAF7	11	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chandran S (2011), Ichimura T (2013)	2
RAB3IP	0	YWHAE	0	affinity chromatography technology	Boldt K (2016)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
SFN	1	CBY1	3	affinity chromatography technology	Mancini M (2015)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
USP2	0	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
MAP3K2	1	STUB1	4	affinity chromatography technology, pull down, enzymatic study	Maruyama T (2010), Maruyama T (2010), Maruyama T (2010)	3
AXIN2	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
GSK3B	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
TRIM25	5	TRAF7	11	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K2	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Greenblatt MB (2016), Greenblatt MB (2016), Greenblatt MB (2016), Greenblatt MB (2016)	4
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
MAP2K7	5	GSK3B	1	biochemical	Wan C (2015)	1
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
YWHAG	5	MAP3K2	1	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Hein MY (2015)	2
HSP90AA1	7	BTRC	1	affinity chromatography technology	Taipale M (2012)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K2	1	PIBF1	2	two hybrid	Bandyopadhyay S (2010)	1
MAP3K2	1	YWHAQ	0	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	MAP2K3	1	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	MAPK7	1	affinity chromatography technology	Taipale M (2012)	1
CTNNB1	30	MAPK8	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee MH (2009), Lee MH (2009), Lee MH (2009)	3
BTRC	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
SFN	1	CTNNB1	30	affinity chromatography technology	Mancini M (2015)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
GSK3B	1	HSP90AA1	7	enzymatic study	Muller P (2012)	1
MAP3K3	3	MAP2K7	5	enzymatic study	Takeda AN (2014)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
CTNNB1	30	CBY1	3	pull down, affinity chromatography technology, affinity chromatography technology	Takemaru K (2003), Takemaru K (2003), Vandepoele K (2010)	3
AXIN1	1	AXIN2	1	affinity chromatography technology	Sue Ng S (2010)	1
NEDD4L	3	YWHAB	1	affinity chromatography technology	Pavlov TS (2010)	1
STAMBP	2	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K2	1	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study	Cheng J (2000), Deacon K (1997), Enomoto A (2008)	3
MAP3K2	1	YWHAZ	1	affinity chromatography technology	Hein MY (2015)	1
MAP3K3	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fang S (2009), Fang S (2009)	2
YWHAB	1	MAP3K2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2004), Couzens AL (2013), Hein MY (2015)	3
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K3	3	MAP2K5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology	Sun W (2001), Bouwmeester T (2004), Sun W (2001), Nakamura K (2010), Lamark T (2003), Lamark T (2003), Erdogan E (2006), Takeda AN (2014), Takeda AN (2014), Chen TC (2014), Huttlin EL (2017)	11
YWHAE	0	MAP3K2	1	pull down, affinity chromatography technology, affinity chromatography technology	Fanger GR (1998), Gloeckner CJ (2007), Hein MY (2015)	3
IKBKG	0	MAP3K2	1	pull down	Fenner BJ (2010)	1
TRIM25	5	MAP2K4	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	STX3	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K3	3	YWHAG	5	affinity chromatography technology	Bouwmeester T (2004)	1
MAPK7	1	MAP3K2	1	affinity chromatography technology	Takeda AN (2014)	1
MAP3K3	3	XIAP	0	pull down, enzymatic study	Takeda AN (2014), Takeda AN (2014)	2
GSK3B	1	XIAP	0	affinity chromatography technology	Sun M (2009)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
STAMBP	2	MAP2K5	1	two hybrid	Tsang HT (2006)	1
SMURF1	4	AXIN1	1	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Fei C (2013), Fei C (2013), Fei C (2014), Fei C (2014), Fei C (2014)	5
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
RAB3IP	0	MAP3K2	1	affinity chromatography technology	Boldt K (2016)	1
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
MAP3K3	3	TRAF7	11	affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Xu LG (2004)	2
MAP3K2	1	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
MAP3K3	3	MAP2K4	3	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Hernandez ED (2014), Hernandez ED (2014)	3
MAP3K2	1	MAPK8	3	affinity chromatography technology, biochemical	Cheng J (2000), Cheng J (2000)	2
AXIN2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von Kries JP (2000), Schwarz-Romond T (2002), Varjosalo M (2013), Varjosalo M (2013)	4
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
MAPK8	3	HSP90AA1	7	affinity chromatography technology	Nieto-Miguel T (2008)	1
MAP2K5	1	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
MAP3K3	3	SMURF1	4	affinity chromatography technology, pull down	Crose LE (2009), Crose LE (2009)	2
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
SFN	1	RAB3IP	0	two hybrid	Rolland T (2014)	1
STK38	0	MAP3K2	1	affinity chromatography technology, affinity chromatography technology	Enomoto A (2008), Enomoto A (2008)	2
AXIN2	1	CTNNB1	30	affinity chromatography technology	von Kries JP (2000)	1
MAP3K3	3	MAP2K3	1	enzymatic study	Deacon K (1997)	1
MAP3K2	1	SMURF1	4	affinity chromatography technology, enzymatic study	Crose LE (2009), Andrews PS (2010)	2
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
HSP90AA1	7	MAP2K7	5	affinity chromatography technology	Taipale M (2012)	1
YWHAZ	1	STK38	0	affinity chromatography technology	Jin J (2004)	1
MAPK8	3	MAP2K7	5	enzymatic study, enzymatic study, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Tournier C (1997), Tournier C (1997), Tournier C (1997), Cheng J (2000), Ho DT (2006), Ho DT (2006), Ho DT (2006), Ho DT (2006), Enomoto A (2003), Takeda AN (2014), Sundarrajan M (2003), Chen TC (2014), Zhu T (2016), Zhu T (2016)	14
MAP3K2	1	STX3	3	affinity chromatography technology	Hein MY (2015)	1
SMURF1	4	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cui Y (2011), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017)	5
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
TRIM25	5	BTRC	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	STK38	0	pull down, affinity chromatography technology	Takeuchi T (2006), Choudhury NR (2017)	2
MAP3K2	1	SH2D2A	2	two hybrid, affinity chromatography technology	Sun W (2001), Sun W (2001)	2
BTRC	1	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
MAP2K5	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K3	3	YWHAE	0	two hybrid, affinity chromatography technology, pull down	Fanger GR (1998), Fanger GR (1998), Fanger GR (1998)	3
YWHAB	1	STK38	0	affinity chromatography technology	Jin J (2004)	1
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
IKBKG	0	BTRC	1	affinity chromatography technology	Orel L (2010)	1
MAP2K5	1	MAPK7	1	two hybrid, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Zhou G (1995), Zhou G (1995), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Huttlin EL (2017)	6
YWHAQ	0	SMURF1	4	affinity chromatography technology	Ichimura T (2013)	1
YWHAG	5	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
BIRC2	1	MAP3K3	3	enzymatic study	Takeda AN (2014)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
MAP3K2	1	XIAP	0	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study	Winsauer G (2008), Winsauer G (2008), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014)	6
GSK3B	1	BTRC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Kitagawa M (1999), Gao C (2014), Gao C (2014), Gao C (2014)	4
SMURF1	4	STK38	0	affinity chromatography technology	Xie Y (2013)	1
BTRC	1	YWHAE	0	affinity chromatography technology	Coyaud E (2015)	1
MAPK7	1	YWHAZ	1	affinity chromatography technology	Erazo T (2013)	1
NEDD4	2	MAP3K3	3	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
MAP3K2	1	MAP3K2	1	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Xu LG (2004), Deacon K (1997), Enomoto A (2008), Enomoto A (2008), Takeda AN (2014)	5
MAP3K2	1	MAP2K5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Sun W (2001), Sun W (2001), Nakamura K (2010), Nakamura K (2010), Wang J (2011), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Huttlin EL (2017)	10
SFN	1	NEDD4L	3	affinity chromatography technology	Benzinger A (2005)	1
HSP90AA1	7	MAP3K2	1	affinity chromatography technology	Taipale M (2012)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
RAB3IP	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
MAP3K3	3	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	MAP2K5	1	affinity chromatography technology	Taipale M (2012)	1
SFN	1	MAP3K2	1	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Hein MY (2015)	2
GSK3B	1	IKBKG	0	imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Medunjanin S (2016), Medunjanin S (2016), Medunjanin S (2016)	4
BTRC	1	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1