PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF274	3	HIST1H1A	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF274	3	MRPL27	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF274	3	RPS27A	1	affinity chromatography technology	Huttlin EL (2017)	1
CBX5	3	ATRX	7	imaging technique, unspecified method, affinity chromatography technology, affinity chromatography technology	Wong LH (2010), Lechner MS (2005), Berube NG (2000), Berube NG (2000)	4
RPS27A	1	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Sun XX (2011), Sun XX (2011), Sun XX (2011), Sun XX (2011), Wang J (2011)	5
ATRX	7	MDM2	2	unspecified method	Li Z (2017)	1
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
CBX5	3	ZNF274	3	affinity chromatography technology	Nozawa RS (2010)	1
CBX5	3	TRIM28	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2002), Cammas F (2002), Cammas F (2002), Nielsen AL (2001), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Ryan RF (1999), Rosnoblet C (2011), Hu C (2012), Hu C (2012), White D (2012), Nozawa RS (2010), Kubota S (2013), Kubota S (2013), Kubota S (2013), Garvin AJ (2013), Huttlin EL (2017), Hauri S (2016)	21
ZNF274	3	MALSU1	2	affinity chromatography technology	Huttlin EL (2017)	1
ATRX	7	ZNF274	3	affinity chromatography technology	Valle-Garcia D (2016)	1
ATRX	7	SETDB1	3	affinity chromatography technology	Valle-Garcia D (2016)	1
MDM2	2	SETDB1	3	two hybrid	Wang J (2011)	1
ZNF10	0	TRIM28	1	two hybrid, pull down, biochemical, pull down, pull down, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, two hybrid, pull down	Moosmann P (1996), Peng H (2000), Peng H (2000), Losson R (2010), Frietze S (2010), Peng H (2007), Peng H (2007), Friedman JR (1996), Peng H (2000), Peng H (2000), Venturini L (1999), Peng H (2000)	12
ATRX	7	TRIM28	1	affinity chromatography technology	Valle-Garcia D (2016)	1
ZNF274	3	SETDB1	3	affinity chromatography technology, affinity chromatography technology	Frietze S (2010), Frietze S (2010)	2
ZNF274	3	RPL26L1	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF10	0	ZNF274	3	biochemical	Peng H (2007)	1
ZNF274	3	TRIM28	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Frietze S (2010), Frietze S (2010), Frietze S (2010), Frietze S (2010), Addison JB (2015), Huttlin EL (2017)	6
TRIM28	1	SETDB1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Schultz DC (2002), Schultz DC (2002), Ivanov AV (2007)	3
ZNF274	3	MDM2	2	affinity chromatography technology	Huttlin EL (2017)	1
ZNF274	3	MRPS14	0	affinity chromatography technology	Huttlin EL (2017)	1
CBX5	3	SETDB1	3	affinity chromatography technology	Loyola A (2009)	1