PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKCA	7	NOXA1	0	enzymatic study	Kroviarski Y (2010)	1
NOXA1	0	RIMBP3	0	two hybrid	Rolland T (2014)	1
HACE1	2	NOXA1	0	affinity chromatography technology	Daugaard M (2013)	1
PRKCG	3	NOXA1	0	two hybrid	Lim J (2006)	1
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	NOXA1	0	enzymatic study	Kroviarski Y (2010)	1
PRKCA	7	NCF1	2	enzymatic study	Fontayne A (2002)	1
NOXA1	0	NOX1	1	affinity chromatography technology	Kroviarski Y (2010)	1
NOXA1	0	RAC1	7	affinity chromatography technology	Kroviarski Y (2010)	1
MAPK11	1	NOXA1	0	enzymatic study	Kroviarski Y (2010)	1
CACNA1A	21	NOXA1	0	two hybrid	Kahle JJ (2011)	1
HACE1	2	RAC1	7	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Torrino S (2011), Torrino S (2011), Torrino S (2011), Castillo-Lluva S (2012), Castillo-Lluva S (2012), Castillo-Lluva S (2012), Daugaard M (2013), Palicharla VR (2015), Andrio E (2017)	9
FAT1	12	NOXA1	0	two hybrid	de Bock CE (2017)	1
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
EP300	36	NOXA1	0	two hybrid	Wang J (2011)	1
NCF1	2	NOXA1	0	two hybrid	Takeshita F (2005)	1
PRKACA	2	NOXA1	0	enzymatic study	Kroviarski Y (2010)	1
PRKCA	7	EP300	36	enzymatic study, affinity chromatography technology	Yuan LW (2000), Rath S (2016)	2