PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX5	11	ARID5A	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
ATXN1	2	ARID5A	4	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
ATXN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
DAB1	1	ARID5A	4	two hybrid	Rolland T (2014)	1
MDFI	1	ARID5A	4	two hybrid	Rolland T (2014)	1
ARID5A	4	KRTAP12-4	0	two hybrid	Rolland T (2014)	1
ESR1	0	ARID5A	4	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Georgescu SP (2005), Georgescu SP (2005), Georgescu SP (2005), Georgescu SP (2005), Georgescu SP (2005)	5
DAB1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
AR	3	ARID5A	4	two hybrid	Georgescu SP (2005)	1
DAZAP2	1	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
PNMA1	0	ARID5A	4	two hybrid	Rolland T (2014)	1
RXRA	1	ARID5A	4	two hybrid	Georgescu SP (2005)	1
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBPMS	0	KRTAP12-2	1	two hybrid	Rolland T (2014)	1
DAZAP2	1	ARID5A	4	two hybrid	Rolland T (2014)	1
CKS1B	0	ARID5A	4	two hybrid	Rolland T (2014)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
DAB1	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
RARA	5	ARID5A	4	two hybrid	Georgescu SP (2005)	1
ARID5A	4	KRT40	0	two hybrid	Rolland T (2014)	1
ESR1	0	GOLGA2	2	affinity chromatography technology	Tarallo R (2011)	1
ARID5A	4	RHOXF2	0	two hybrid	Rolland T (2014)	1
ARID5A	4	RBPMS	0	two hybrid	Rolland T (2014)	1
ARID5A	4	KRTAP12-2	1	two hybrid	Rolland T (2014)	1
ESR2	1	ARID5A	4	two hybrid	Georgescu SP (2005)	1
THRA	2	RXRA	1	biochemical, affinity chromatography technology, two hybrid, pull down, imaging technique	Bugge TH (1992), Sharma D (2000), Albers M (2005), Liao CS (2009), Liao CS (2009)	5
THRA	2	ARID5A	4	two hybrid	Georgescu SP (2005)	1
SH2D2A	2	ARID5A	4	two hybrid	Grossmann A (2015)	1
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
GOLGA2	2	ARID5A	4	two hybrid	Rolland T (2014)	1