PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAFD1	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	TRAFD1	2	affinity chromatography technology	Kirli K (2015)	1
CFTR	5	CLTC	12	affinity chromatography technology	Pankow S (2015)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
EGFR	5	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Yao Z (2017)	4
TRAFD1	2	ASPM	9	affinity chromatography technology	Huttlin EL (2017)	1
RIPK4	0	ILK	0	affinity chromatography technology	Rodriguez J (2016)	1
CFTR	5	KDELR1	1	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	XPO1	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
CLTC	12	TRAFD1	2	affinity chromatography technology	Hein MY (2015)	1
HSPA5	0	TRAFD1	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	ASPM	9	affinity chromatography technology	Rodriguez J (2016)	1
CFTR	5	TES	1	affinity chromatography technology	Pankow S (2015)	1
VHL	0	TRAFD1	2	affinity chromatography technology	Lai Y (2011)	1
CFTR	5	HSPA5	0	affinity chromatography technology	Pankow S (2015)	1
TRAFD1	2	NAA15	9	affinity chromatography technology	Huttlin EL (2017)	1
TRAFD1	2	ACAD11	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
PAN2	3	TRAFD1	2	affinity chromatography technology	Bett JS (2013)	1
EGLN3	0	MAPK6	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
CFTR	5	TRAFD1	2	affinity chromatography technology	Pankow S (2015)	1
ILK	0	XPO1	8	affinity chromatography technology	So J (2015)	1
BAG6	2	TRAFD1	2	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
ILK	0	TRAFD1	2	affinity chromatography technology	Varjosalo M (2013)	1
KDELR1	1	TRAFD1	2	affinity chromatography technology	Huttlin EL (2017)	1
HTT	14	TRAFD1	2	two hybrid	Suter B (2013)	1
MAPK6	1	ASPM	9	affinity chromatography technology	Rodriguez J (2016)	1
HTT	14	EGFR	5	affinity chromatography technology	Liu YF (1997)	1
FAM46A	2	TRAFD1	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	TRAFD1	2	affinity chromatography technology	Rodriguez J (2016)	1
TRAFD1	2	BBS4	2	affinity chromatography technology	Boldt K (2016)	1
ZNF131	0	TRAFD1	2	affinity chromatography technology	Varier RA (2016)	1
TRAFD1	2	NGLY1	0	two hybrid	Rolland T (2014)	1
PAN2	3	CLTC	12	affinity chromatography technology	Bett JS (2013)	1
EGFR	5	NGLY1	0	affinity chromatography technology	Tong J (2014)	1
ALG10B	0	TRAFD1	2	affinity chromatography technology	Huttlin EL (2017)	1
FAM46A	2	BAG6	2	two hybrid	Colland F (2004)	1
EGLN3	0	ILK	0	affinity chromatography technology	Rodriguez J (2016)	1
EGFR	5	TRAFD1	2	affinity chromatography technology	Yao Z (2017)	1
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
EGLN3	0	TRAFD1	2	affinity chromatography technology	Rodriguez J (2016)	1
XKRX	1	TRAFD1	2	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	HSPA5	0	pull down	Lai Y (2012)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
PAN2	3	HSPA5	0	affinity chromatography technology	Bett JS (2013)	1
EGLN3	0	BAG6	2	affinity chromatography technology	Rodriguez J (2016)	1
HTT	14	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2011), Zucchelli S (2011)	2
TES	1	TRAFD1	2	affinity chromatography technology	Sala S (2017)	1
TRAF6	0	TRAFD1	2	pull down	Mashima R (2005)	1
UBC	7	HSPA5	0	pull down	Nathan JA (2013)	1
HSPA5	0	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
RIPK4	0	BAG6	2	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	TRAFD1	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
TES	1	BAG6	2	affinity chromatography technology	Sala S (2017)	1
MAPK6	1	TRAFD1	2	affinity chromatography technology	Rodriguez J (2016)	1
TES	1	CLTC	12	affinity chromatography technology	Sala S (2017)	1
CDK20	0	TRAFD1	2	affinity chromatography technology	Varjosalo M (2013)	1
MAPK6	1	BAG6	2	two hybrid, affinity chromatography technology	Vinayagam A (2011), Rodriguez J (2016)	2
RIPK4	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1