Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
RALBP1 10928 CARBAMAZEPINE CHEMBL108 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
RALBP1 rs329007 GG bevacizumab efficacy yes Patients were receiving treatment with bevacizumab + FOLFIRI (fluorouracil, leucovorin, irinotecan). Patients with the GG genotype had a significantly lower tumor response rate according to the RECIST criteria. However, when the p-value was adjusted for multiple testing, it was no longer significant (p=0.63). When considering only tumors on the left-sided colon and rectum, this SNP was also associated with tumor response rate. Genotype GG is associated with decreased response to bevacizumab, fluorouracil, irinotecan and leucovorin in people with Colorectal Neoplasms as compared to genotypes AA + AG. 25069475 1444934857