PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNW1	0	CPSF2	2	affinity chromatography technology	Lleres D (2010)	1
HCFC1	4	CLP1	2	two hybrid	Zhou HJ (2001)	1
CREB3	1	HCFC1	4	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu R (1998), Lu R (1998), Freiman RN (1997), Freiman RN (1997), Lu R (1997), Lu R (1997), Misra V (2005), DenBoer LM (2013), Huttlin EL (2015), Huttlin EL (2017)	10
TSEN15	0	CLP1	2	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Huttlin EL (2017)	2
HMCN1	7	CLP1	2	biochemical	Wan C (2015)	1
SNW1	0	PCF11	2	affinity chromatography technology	Lleres D (2010)	1
CPSF6	1	PCF11	2	biochemical	Wan C (2015)	1
CPSF6	1	CPSF7	4	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015), Huttlin EL (2017)	3
CLP1	2	APP	1	pull down	Olah J (2011)	1
PCF11	2	CPSF2	2	biochemical	Wan C (2015)	1
MBLAC1	0	CLP1	2	affinity chromatography technology	Huttlin EL (2017)	1
CLP1	2	CPSF2	2	affinity chromatography technology	de Vries H (2000)	1
NUDT21	0	CPSF6	1	two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
CLP1	2	CPSF7	4	affinity chromatography technology	de Vries H (2000)	1
NUDT21	0	CPSF7	4	two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Wan C (2015), Hein MY (2015), Hein MY (2015)	5
SNW1	0	CPSF7	4	affinity chromatography technology	Lleres D (2010)	1
AMMECR1	2	CLP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CLP1	2	CREB3	1	two hybrid, pull down	Zhou HJ (2001), Zhou HJ (2001)	2
CLP1	2	CPSF6	1	affinity chromatography technology	de Vries H (2000)	1
TSEN2	5	CLP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
AMMECR1	2	TSEN54	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSEN2	5	TSEN15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
TSEN2	5	TSEN54	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Rolland T (2014), Huttlin EL (2017)	4
SNW1	0	CPSF6	1	affinity chromatography technology	Lleres D (2010)	1
TSEN34	2	TSEN54	1	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004)	2
CLP1	2	NUDT21	0	affinity chromatography technology	de Vries H (2000)	1
CLP1	2	TSEN54	1	affinity chromatography technology	Paushkin SV (2004)	1
NUDT21	0	PCF11	2	biochemical	Wan C (2015)	1
PCF11	2	CLP1	2	biochemical	Wan C (2015)	1
SNW1	0	CLP1	2	affinity chromatography technology	Lleres D (2010)	1
CLP1	2	TSEN34	2	affinity chromatography technology	Paushkin SV (2004)	1
TSEN54	1	TSEN15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
TSEN15	0	TSEN34	2	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Huttlin EL (2017)	2
TSEN2	5	TSEN34	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3