PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTEN	24	CASP8	1	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
SMAD4	9	IL24	0	two hybrid	Arroyo R (2015)	1
HRAS	2	IL24	0	two hybrid	Arroyo R (2015)	1
FBXW7	2	IL24	0	two hybrid	Arroyo R (2015)	1
LSP1	3	IL24	0	two hybrid	Arroyo R (2015)	1
PIK3CA	8	IL24	0	two hybrid	Arroyo R (2015)	1
KRAS	1	FBXW7	2	genetic interference	Luo J (2009)	1
IL24	0	CLU	1	pull down, pull down	Bhutia SK (2012), Bhutia SK (2012)	2
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
CASP8	1	IL24	0	two hybrid	Arroyo R (2015)	1
PTEN	24	IL24	0	two hybrid	Arroyo R (2015)	1
ATM	9	IL24	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
CCR5	1	IL24	0	two hybrid	Wang J (2011)	1
RB1CC1	9	IL24	0	two hybrid	Arroyo R (2015)	1
PTEN	24	AKT1	1	affinity chromatography technology, fluorescent resonance energy transfe	Mistafa O (2010), Ivanov AA (2017)	2
DCD	0	IL24	0	two hybrid	Wang J (2011)	1
PARP1	3	IL24	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
BAG4	2	IL24	0	two hybrid	Arroyo R (2015)	1
PALB2	3	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dray E (2010), Hayakawa T (2010), Zhang F (2009), Zhang F (2009), Xia B (2006), Anantha RW (2013), Bleuyard JY (2012), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Foo TK (2017), Foo TK (2017)	18
ESR2	1	IL24	0	two hybrid	Arroyo R (2015)	1
PIK3CA	8	HRAS	2	pull down, two hybrid, pull down	Vargiu P (2004), Li W (2000), Rodriguez-Viciana P (1996)	3
NOTCH2	10	IL24	0	two hybrid	Arroyo R (2015)	1
APC	5	IL24	0	two hybrid	Arroyo R (2015)	1
IL24	0	RARG	2	two hybrid	Wang J (2011)	1
PALB2	3	IL24	0	two hybrid	Arroyo R (2015)	1
AKT1	1	IL24	0	two hybrid	Arroyo R (2015)	1
CHEK2	2	IL24	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015), Arroyo R (2015)	3
KRAS	1	PIK3CA	8	two hybrid, genetic interference	Li W (2000), Hart T (2015)	2
RAD51	3	IL24	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
HMMR	1	IL24	0	two hybrid	Arroyo R (2015)	1
PIK3CA	8	AKT1	1	affinity chromatography technology, protein complementation assay, affinity chromatography technology, enzymatic study	Mitra S (2011), Miao B (2010), Xiong Y (2009), Akil H (2015)	4
FBXW7	2	PTEN	24	affinity chromatography technology, affinity chromatography technology	Yang C (2013), Yang C (2013)	2
KRAS	1	IL24	0	two hybrid	Arroyo R (2015)	1
ATM	9	CHEK2	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Lee JH (2004), Lee JH (2004), Matsuoka S (2000), Lee JH (2005), Zhou BB (2000), Chan DW (2000)	6
ATM	9	PARP1	3	pull down	Haince JF (2007)	1
RAD51	3	ATM	9	affinity chromatography technology, affinity chromatography technology	Chen G (1999), Chen G (1999)	2
CASP8	1	PARP1	3	enzymatic study	Betin VM (2009)	1