PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LATS1	3	PTPN14	5	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Wilson KE (2014), Wilson KE (2014)	3
ERBB4	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, pull down	Sundvall M (2008), Sundvall M (2008), Sundvall M (2008), Omerovic J (2007), Omerovic J (2007), Omerovic J (2007)	6
DVL2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Wei W (2012), Wei W (2012), Wei W (2012), Mund T (2015), Mund T (2015), Mund T (2015)	6
SMAD1	0	SKIL	3	affinity chromatography technology	Mizuide M (2003)	1
TXNIP	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, bioid	Zhang P (2010), Zhang P (2010), Zhang P (2010), Liu Y (2016), Liu Y (2016), Forred BJ (2016)	6
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
ATN1	2	WWP2	7	two hybrid, pull down, two hybrid	Wood JD (1998), Wood JD (1998), Lim J (2006)	3
PTPN14	5	WWP2	7	affinity chromatography technology, affinity chromatography technology	Wang W (2012), Chaudhary N (2014)	2
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
406979	0	HNRNPL	3	affinity chromatography technology	Treiber T (2017)	1
TRAF6	0	WWP1	3	affinity chromatography technology	Lin XW (2013)	1
WWP1	3	RTN4	4	pull down, affinity chromatography technology	Qin H (2008), Qin H (2008)	2
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
WBP2	0	WWP2	7	unspecified method, affinity chromatography technology, two hybrid, pull down	Pirozzi G (1997), Chaudhary N (2014), Lim SK (2016), Lim SK (2016)	4
SMAD5	2	SMAD6	9	affinity chromatography technology	Murakami G (2003)	1
HSPB1	2	WWP1	3	two hybrid	Katsogiannou M (2014)	1
CPSF6	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ingham RJ (2005), Ingham RJ (2005), Ingham RJ (2005), OConnor HF (2015), Huttlin EL (2017)	5
XRCC5	5	RUNX2	2	affinity chromatography technology	Willis DM (2002)	1
EWSR1	2	WWP2	7	two hybrid	Rual JF (2005)	1
SMAD6	9	WWP2	7	affinity chromatography technology	Herhaus L (2014)	1
ITCH	1	LAPTM5	3	affinity chromatography technology, enzymatic study	Ishihara T (2011), Ishihara T (2011)	2
TRAF4	1	WWP2	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
STAT6	1	WWP1	3	two hybrid	Ravasi T (2010)	1
RUNX2	2	HIVEP3	12	affinity chromatography technology, pull down	Jones DC (2006), Jones DC (2006)	2
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
LZTR1	16	IKBKG	0	two hybrid	Ravasi T (2010)	1
HNRNPL	3	WWP1	3	affinity chromatography technology	Fei T (2017)	1
406980	0	WWP2	7	affinity chromatography technology	Treiber T (2017)	1
PCBD1	0	WWP1	3	two hybrid	Ravasi T (2010)	1
SPART	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Milewska M (2009), Edwards TL (2009), Hooper C (2010), Eastman SW (2009), Ingham RJ (2005), Huttlin EL (2017)	6
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
HNRNPL	3	TMEM255B	0	affinity chromatography technology	Fei T (2017)	1
EZR	8	WWP1	3	affinity chromatography technology	Zaarour RF (2012)	1
TMEM255A	0	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP1	3	KLF2	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Conkright MD (2001), Conkright MD (2001), Zhang X (2004)	3
UBE2D3	1	WWP2	7	pull down, pull down, pull down	Maspero E (2013), Lv Y (2014), Kristariyanto YA (2015)	3
CPSF6	1	WWP1	3	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Xin X (2009), Huttlin EL (2017)	4
LDLRAD4	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
WBP1	1	WWP2	7	unspecified method	Pirozzi G (1997)	1
WWP1	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
ESR2	1	KLF5	4	pull down, affinity chromatography technology, affinity chromatography technology	Nakajima Y (2011), Nakajima Y (2011), Nakajima Y (2011)	3
TRAF4	1	FBXL18	5	two hybrid	Rolland T (2014)	1
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
WBP1	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD5	2	WWP1	3	affinity chromatography technology, two hybrid	Komuro A (2004), Colland F (2004)	2
NOTCH1	25	DAZAP2	1	two hybrid	Daakour S (2016)	1
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
SMAD4	9	SMAD5	2	affinity chromatography technology, two hybrid, two hybrid	Hanai J (1999), Haag J (2006), Colland F (2004)	3
WWP2	7	SFTPC	0	pull down	Kotorashvili A (2009)	1
FAM189A2	2	YWHAQ	0	affinity chromatography technology	Huttlin EL (2017)	1
CPSF6	1	WWP2	7	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
WWP2	7	DIDO1	9	two hybrid	Rual JF (2005)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
LNX1	7	UBE2D2	0	pull down, pull down, pull down	Nie J (2002), Nie J (2004), Guo Z (2012)	3
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
ARRDC1	4	WWP1	3	pull down, two hybrid, affinity chromatography technology	Rauch S (2011), Rauch S (2011), Huttlin EL (2017)	3
WWP2	7	FBXL18	5	two hybrid	Rolland T (2014)	1
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
WWP1	3	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
TP63	0	CPSF6	1	affinity chromatography technology	Amoresano A (2010)	1
ILDR1	2	ITCH	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	XRCC5	5	affinity chromatography technology	Fei T (2017)	1
ATN1	2	WWP1	3	two hybrid, two hybrid	Wood JD (1998), Lim J (2006)	2
ASH2L	2	WWP1	3	two hybrid	Wang J (2011)	1
SMAD2	5	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
LZTR1	16	WWP1	3	two hybrid	Ravasi T (2010)	1
LDLRAD4	1	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	ZNF638	8	affinity chromatography technology	Fei T (2017)	1
CDK8	1	WWP1	3	affinity chromatography technology	Hein MY (2015)	1
RNF11	0	SMAD4	9	affinity chromatography technology	Azmi PB (2009)	1
LATS1	3	PTEN	24	enzymatic study	Chiyoda T (2012)	1
HNRNPL	3	SCNN1A	1	affinity chromatography technology	Fei T (2017)	1
SARAF	0	ITCH	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	PRKAA2	1	affinity chromatography technology	Fei T (2017)	1
WWP2	7	SCNN1A	1	pull down	McDonald FJ (2002)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
DAZAP2	1	WWP1	3	two hybrid	Rual JF (2005)	1
CDK8	1	SMAD1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009), Alarcon C (2009)	3
YWHAQ	0	HSPB1	2	affinity chromatography technology, two hybrid	Pozuelo-Rubio M (2010), Katsogiannou M (2014)	2
TXNIP	2	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
FAM189A2	2	WWP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
ESR2	1	WWP1	3	affinity chromatography technology, affinity chromatography technology	Nakajima Y (2011), Nakajima Y (2011)	2
PTEN	24	NOTCH1	25	genetic interference	Vizeacoumar FJ (2013)	1
RUNX2	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Jones DC (2006), Jones DC (2006)	2
ATN1	2	EWSR1	2	two hybrid, bioid	Lim J (2006), Elzi DJ (2014)	2
EZH2	4	HSPB1	2	affinity chromatography technology	Cao Q (2014)	1
LNX1	7	WWP1	3	two hybrid	Wolting CD (2011)	1
EZH2	4	WWP1	3	affinity chromatography technology	Cao Q (2014)	1
FAM189A2	2	WWP2	7	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
EZH2	4	FBXL18	5	affinity chromatography technology	Cao Q (2014)	1
HSP90AA1	7	ERBB4	5	affinity chromatography technology	Taipale M (2012)	1
PRKAA2	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Lee JO (2013), Lee JO (2013), Lee JO (2013), Lee JO (2013)	4
TRAF4	1	WWP1	3	two hybrid	Rolland T (2014)	1
RNF11	0	WWP1	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, pull down, two hybrid	Chen C (2008), Chen C (2008), Chen C (2008), Chen C (2008), Chen C (2008), Colland F (2004)	6
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
PTEN	24	UBE2L3	1	affinity chromatography technology	Waite KA (2003)	1
PTPN14	5	ZNF638	8	affinity chromatography technology	Boldt K (2016)	1
DVL2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Mund T (2015), Mund T (2015), Mund T (2015)	3
ARRDC1	4	ITCH	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Shea FF (2012), Puca L (2013), Huttlin EL (2015), Huttlin EL (2017)	5
LITAF	0	WWP2	7	affinity chromatography technology	Li W (2015)	1
EZH2	4	CPSF6	1	affinity chromatography technology	Cao Q (2014)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
CDK8	1	SMAD3	1	enzymatic study	Alarcon C (2009)	1
406979	0	CPSF6	1	affinity chromatography technology	Treiber T (2017)	1
IKBKG	0	WWP1	3	two hybrid	Ravasi T (2010)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
ATN1	2	DVL2	5	two hybrid	Lim J (2006)	1
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
WWP2	7	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Xu H (2009), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Chen Z (2016)	6
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
KLF5	4	SMAD3	1	affinity chromatography technology	Guo P (2009)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
406980	0	CPSF6	1	affinity chromatography technology	Treiber T (2017)	1
HSP90AA1	7	FBXL15	0	affinity chromatography technology	Taipale M (2012)	1
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
PTCH1	8	ITCH	1	affinity chromatography technology, affinity chromatography technology	Chen XL (2014), Chen XL (2014)	2
SARAF	0	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
PTCH1	8	CPSF6	1	affinity chromatography technology	Yamaki Y (2016)	1
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
WWP1	3	SKIL	3	affinity chromatography technology	Komuro A (2004)	1
EWSR1	2	SMAD4	9	two hybrid	Rual JF (2005)	1
UBC	7	PHF20L1	4	pull down	Nathan JA (2013)	1
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
WWP1	3	SFTPC	0	pull down	Kotorashvili A (2009)	1
KLF5	4	SMAD4	9	affinity chromatography technology	Guo P (2009)	1
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
HSPB1	2	HSP90AA1	7	two hybrid	Katsogiannou M (2014)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
RNF11	0	YWHAQ	0	affinity chromatography technology	Connor MK (2005)	1
406980	0	HNRNPL	3	affinity chromatography technology	Treiber T (2017)	1
WWP2	7	UBE2D2	0	pull down, pull down, pull down	Sheng Y (2012), Kristariyanto YA (2015), Chaudhary N (2014)	3
ARRDC1	4	WWP2	7	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rauch S (2011), Nabhan JF (2012), Shea FF (2012), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
WWP1	3	ERBB4	5	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li Y (2009), Li Y (2009), Li Y (2009), Feng SM (2009), Feng SM (2009)	5
TMEM255B	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP1	3	DIDO1	9	two hybrid	Rual JF (2005)	1
PTPN14	5	UBC	7	affinity chromatography technology	Wang W (2012)	1
SMAD2	5	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
FAM189A2	2	FAM189B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2L3	1	SMAD7	1	unspecified method	Ogunjimi AA (2005)	1
SCNN1A	1	WWP1	3	two hybrid	Malbert-Colas L (2003)	1
ITCH	1	WBP2	0	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Ingham RJ (2005), OConnor HF (2015), Lim SK (2016), Lim SK (2016), Lim SK (2016), Lim SK (2016), Lim SK (2016)	7
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
PTPN14	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Wang W (2012), Li X (2016)	2
HSPB1	2	XRCC5	5	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Katsogiannou M (2014)	2
ITCH	1	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Wiesner S (2007), Ishihara T (2011), Scialpi F (2008), Bai Y (2004), Oberst A (2007), Mouchantaf R (2006), Rossi M (2005), Zhang P (2010), Anindya R (2007), Kathania M (2015), Kristariyanto YA (2015), Riling C (2015), Riling C (2015), Zhang W (2016)	14
RUNX2	2	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Jun JH (2010), Wang Q (2007)	5
HSP90AA1	7	LNX1	7	affinity chromatography technology	Taipale M (2012)	1
WBP2	0	WWP1	3	unspecified method, two hybrid	Pirozzi G (1997), Lim SK (2016)	2
ARRDC2	0	WWP1	3	pull down	Rauch S (2011)	1
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
SPART	0	WWP2	7	two hybrid, affinity chromatography technology	Eastman SW (2009), Chaudhary N (2014)	2
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
WWP2	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid	Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011)	6
WWP1	3	WWP1	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Anindya R (2007), Courivaud T (2015), Zhang W (2016), Chen Z (2017)	4
WWP2	7	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
FAM189B	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP1	3	UBE2L3	1	pull down, pull down, pull down, pull down, pull down	Peschiaroli A (2010), Anindya R (2007), Kristariyanto YA (2015), Courivaud T (2015), Zhang W (2016)	5
ITCH	1	TP63	0	affinity chromatography technology, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down	Rossi M (2006), Bellomaria A (2010), Bellomaria A (2010), Bellomaria A (2012), Bellomaria A (2012), Salah Z (2013), Melino S (2014)	7
XRCC5	5	WWP1	3	affinity chromatography technology	Hein MY (2015)	1
SCNN1A	1	ITCH	1	far western blotting	Harvey KF (2001)	1
HSP90AA1	7	PRKAA2	1	affinity chromatography technology	Taipale M (2012)	1
SPART	0	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Edwards TL (2009), Eastman SW (2009), Eastman SW (2009), Eastman SW (2009), Eastman SW (2009), Huttlin EL (2017)	7
PTPN21	10	WWP1	3	affinity chromatography technology	Li X (2016)	1
SMAD5	2	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
HNRNPL	3	WWP2	7	affinity chromatography technology	Fei T (2017)	1
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
UBC	7	HSPB1	2	affinity chromatography technology	Matsumoto M (2005)	1
YWHAQ	0	ESR2	1	pull down	Zilliacus J (2001)	1
LATS1	3	WWP1	3	unspecified method	Salah Z (2013)	1
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
DVL2	5	WWP2	7	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Mund T (2015), Mund T (2015), Mund T (2015), Mund T (2015), Chaudhary N (2014)	5
PTCH1	8	WWP2	7	affinity chromatography technology, affinity chromatography technology	Chen XL (2014), Chen XL (2014)	2
YWHAQ	0	WWP1	3	pull down	Meek SE (2004)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
PCBD1	0	LNX1	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TMEM255A	0	WWP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM51	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK8	1	SMAD5	2	affinity chromatography technology	Alarcon C (2009)	1
ESR2	1	CDK8	1	pull down	Kang YK (2002)	1
ESR2	1	HSP90AA1	7	affinity chromatography technology	Powell E (2010)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
HNRNPL	3	CDK8	1	affinity chromatography technology	Fei T (2017)	1
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
UBC	7	FBXL15	0	pull down	Zhang X (2017)	1
SETD4	1	WWP1	3	affinity chromatography technology	Hein MY (2015)	1
LITAF	0	WWP1	3	affinity chromatography technology	Li W (2015)	1
EZH2	4	WWP2	7	affinity chromatography technology	Cao Q (2014)	1
ITCH	1	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
WBP1	1	WWP1	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Huttlin EL (2015), Huttlin EL (2017)	3
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
HNRNPL	3	HIVEP3	12	affinity chromatography technology	Fei T (2017)	1
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LDLRAD4	1	WWP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD6	9	ITCH	1	affinity chromatography technology	Herhaus L (2014)	1
PTEN	24	WWP2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study	Crockett DK (2005), Ahmed SF (2012), Wu Y (2013), Maddika S (2011), Maddika S (2011), Maddika S (2011), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Chen Z (2016), Chen Z (2016), Chen Z (2017)	12
SMAD6	9	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Herhaus L (2014)	3
FAM189B	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC3	0	ITCH	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
WWP2	7	YWHAQ	0	affinity chromatography technology	Chaudhary N (2014)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
HIVEP3	12	WWP1	3	affinity chromatography technology	Jones DC (2006)	1
WWP1	3	NOTCH1	25	pull down, imaging technique	Flasza M (2006), Flasza M (2006)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
LDLRAD4	1	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTEN	24	WWP1	3	affinity chromatography technology, affinity chromatography technology	Li N (2015), Maddika S (2011)	2
SMAD2	5	KLF5	4	affinity chromatography technology, affinity chromatography technology	Brown KA (2008), Guo P (2009)	2
EZH2	4	ZNF638	8	affinity chromatography technology	Cao Q (2014)	1
WWP2	7	UBE2D1	0	pull down, pull down	Kristariyanto YA (2015), Chen Z (2016)	2
WWP1	3	ZNF638	8	two hybrid	Rual JF (2005)	1
TMEM51	2	WWP2	7	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
DIDO1	9	H2AFY2	0	biochemical	Havugimana PC (2012)	1
PHF20L1	4	WWP1	3	two hybrid	Wang J (2011)	1
ARRDC3	0	WWP1	3	pull down, affinity chromatography technology	Rauch S (2011), Huttlin EL (2017)	2
FAM189A2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
LATS1	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, unspecified method	Salah Z (2011), Salah Z (2011), Salah Z (2011), Ho KC (2011), Adler JJ (2013), Ho KC (2011), Ho KC (2011), Ho KC (2011), Salah Z (2013)	9
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
WWP1	3	KLF5	4	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Chen C (2005), Chen C (2005), Chen C (2005), Nakajima Y (2011), Zhao D (2011), Chen C (2010)	6
PTCH1	8	WWP1	3	affinity chromatography technology	Chen XL (2014)	1
ITCH	1	EWSR1	2	pull down	Ingham RJ (2005)	1
SMAD3	1	TP63	0	affinity chromatography technology	Lu D (2013)	1
ITCH	1	LITAF	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Eaton HE (2011), Eaton HE (2011), Li W (2015)	3
WWP1	3	UBE2D3	1	pull down	Kristariyanto YA (2015)	1
HSP90AA1	7	WWP1	3	affinity chromatography technology	Taipale M (2012)	1
EWSR1	2	CPSF6	1	two hybrid	Rual JF (2005)	1
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
WWP1	3	FBXL18	5	two hybrid	Rolland T (2014)	1
HSP90AA1	7	FBXL18	5	affinity chromatography technology	Taipale M (2012)	1
EWSR1	2	XRCC5	5	affinity chromatography technology	Elzi DJ (2014)	1
UBC	7	HIVEP3	12	affinity chromatography technology	Matsumoto M (2005)	1
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
406979	0	WWP1	3	affinity chromatography technology	Treiber T (2017)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
UBC	7	SPART	0	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
406979	0	WWP2	7	affinity chromatography technology	Treiber T (2017)	1
WWP1	3	TP63	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Peschiaroli A (2010), Peschiaroli A (2010), Li Y (2008)	3
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
SMAD3	1	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
TNFRSF19	5	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
EWSR1	2	WWP1	3	two hybrid	Rual JF (2005)	1
TP63	0	HNRNPL	3	affinity chromatography technology	Amoresano A (2010)	1
STAT6	1	DAZAP2	1	two hybrid	Ravasi T (2010)	1
STAT6	1	LITAF	0	pull down, two hybrid	Tang X (2005), Tang X (2005)	2
CDK8	1	SMAD2	5	enzymatic study	Alarcon C (2009)	1
LAPTM5	3	WWP1	3	two hybrid	Colland F (2004)	1
H2AFY2	0	WWP1	3	two hybrid	Wang J (2011)	1
HNRNPL	3	TNFRSF19	5	affinity chromatography technology	Fei T (2017)	1
PTEN	24	UBE2D1	0	genetic interference	Vizeacoumar FJ (2013)	1
HNRNPL	3	H2AFY2	0	affinity chromatography technology	Fei T (2017)	1
ARRDC3	0	WWP2	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Dores MR (2015)	3
EWSR1	2	EZH2	4	two hybrid, affinity chromatography technology	Ravasi T (2010), Cao Q (2014)	2
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
PTEN	24	HSP90AA1	7	affinity chromatography technology, genetic interference	Maddika S (2011), Shen JP (2017)	2
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
TMEM255A	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ILDR1	2	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
SMAD3	1	RUNX2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Ohyama Y (2011)	4
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TMEM51	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
HNRNPL	3	PTEN	24	affinity chromatography technology	Fei T (2017)	1
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
PTEN	24	PTPN14	5	affinity chromatography technology	Crockett DK (2005)	1
WWP1	3	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
DVL2	5	PCBD1	0	two hybrid	Rual JF (2005)	1
LNX1	7	TRAF4	1	affinity chromatography technology	Lenihan JA (2017)	1
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
ATN1	2	ITCH	1	two hybrid, pull down	Wood JD (1998), Wood JD (1998)	2
SMAD1	0	UBC	7	two hybrid	Guo X (2001)	1
406980	0	WWP1	3	affinity chromatography technology	Treiber T (2017)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1