PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPP1CC	2	AKT1	1	affinity chromatography technology	Flores-Delgado G (2007)	1
ESR1	0	8339	0	pull down	Nalvarte I (2010)	1
TFAP4	3	MDC1	8	affinity chromatography technology	Ku WC (2009)	1
MSH6	2	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
ATRIP	1	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2003), Wang Y (2003), Cortez D (2004), Cortez D (2001), Cortez D (2001), Cortez D (2001), Cortez D (2001), Rendtlew Danielsen JM (2009), Kulkarni A (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Itakura E (2004), Itakura E (2004), Itakura E (2004), Pabla N (2008), Pabla N (2011), Collis SJ (2007), Collis SJ (2007), Warmerdam DO (2010), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Bomgarden RD (2004), Choi JH (2007), Lovejoy CA (2009), Huttlin EL (2017)	27
PPP1CC	2	ATM	9	affinity chromatography technology	Flores-Delgado G (2007)	1
PMS2	4	MSH6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Matton N (2000), Matton N (2000), Plotz G (2003)	4
ATM	9	E2F1	0	enzymatic study	Lin WC (2001)	1
ATR	6	RPA1	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Pabla N (2008), Marechal A (2014)	3
ERCC1	1	TOPBP1	5	biochemical	Wan C (2015)	1
EGLN3	0	MSH6	2	affinity chromatography technology	Rodriguez J (2016)	1
TOPBP1	5	POLE	10	affinity chromatography technology	Maekiniemi M (2001)	1
BRCA1	7	BLM	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Acharya S (2014), Ertych N (2016)	3
BARD1	4	BRIP1	2	unspecified method, affinity chromatography technology	Thanassoulas A (2010), Wu W (2016)	2
TOPBP1	5	RAD9A	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maekiniemi M (2001), Maekiniemi M (2001), Maekiniemi M (2001), Delacroix S (2007), Greer DA (2003)	5
BRCA1	7	HSPA8	4	two hybrid, affinity chromatography technology	Yu X (1998), Ertych N (2016)	2
ABL1	9	TOPBP1	5	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zeng L (2005), Zeng L (2005), Zeng L (2005), Zeng L (2005)	4
AKT1	1	TOPBP1	5	enzymatic study, affinity chromatography technology	Liu K (2006), Liu K (2006)	2
SMARCA4	19	TOP2B	9	biochemical	Havugimana PC (2012)	1
ATRIP	1	TELO2	6	affinity chromatography technology	Collis SJ (2007)	1
BRCA1	7	TOPBP1	5	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenberg RA (2006), Mok MT (2010), Tian F (2013), Hill SJ (2014), Sakasai R (2012)	5
ATR	6	NBN	1	unspecified method, pull down, affinity chromatography technology	Kim ST (1999), Falck J (2005), Falck J (2005)	3
TOPBP1	5	SMARCAD1	1	two hybrid, pull down	Bantele SC (2017), Bantele SC (2017)	2
POLE	10	MSH6	2	biochemical	Wan C (2015)	1
EGLN3	0	BLM	2	affinity chromatography technology	Rodriguez J (2016)	1
8339	0	BARD1	4	bioid	Lambert JP (2015)	1
RAD9A	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Yoshida K (2002), Yoshida K (2002), Yoshida K (2002), Yoshida K (2002)	4
ATM	9	CHEK1	2	unspecified method, enzymatic study, genetic interference	Kim ST (1999), Sorensen CS (2003), Shen JP (2017)	3
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
ESR1	0	DCAF1	5	affinity chromatography technology, affinity chromatography technology	Britschgi A (2017), Britschgi A (2017)	2
ESR1	0	HSPA5	0	affinity chromatography technology	Dhamad AE (2016)	1
ACAT1	1	TOPBP1	5	biochemical	Havugimana PC (2012)	1
TOPBP1	5	BLM	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Wang J (2013), Wang J (2013), Wang J (2013), Wang J (2013), Wang J (2013), Wang J (2013), Wang J (2013)	7
PMS2	4	BRIP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Xie J (2010), Peng M (2007), Peng M (2007), Hein MY (2015), Mori R (2013)	6
TOPBP1	5	SMC4	2	affinity chromatography technology	Wang J (2013)	1
EGLN3	0	POLE	10	affinity chromatography technology	Rodriguez J (2016)	1
PPP1CC	2	TOPBP1	5	two hybrid	Fardilha M (2011)	1
RAD9A	1	MSH6	2	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
PPP1CC	2	ESR1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
RPA1	0	RMI1	0	affinity chromatography technology	Marechal A (2014)	1
EGLN3	0	DCAF1	5	affinity chromatography technology	Rodriguez J (2016)	1
TELO2	6	ATM	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kaizuka T (2010), Takai H (2010), Takai H (2007), Takai H (2007)	4
TOPBP1	5	HIST2H4A	0	affinity chromatography technology	Wang J (2013)	1
PMS2	4	DDB1	6	affinity chromatography technology	Cannavo E (2007)	1
8339	0	TOPBP1	5	bioid	Lambert JP (2015)	1
TOPBP1	5	TOP2B	9	two hybrid	Yamane K (1997)	1
ATM	9	TOPBP1	5	affinity chromatography technology	Perfettini JL (2009)	1
TOPBP1	5	ATRIP	1	affinity chromatography technology	Venere M (2007)	1
BLM	2	RPA1	0	pull down, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brosh RM (2000), Opresko PL (2002), Moens PB (2002), Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Wang J (2013), Marechal A (2014), Chaudhury I (2014), Elia AE (2015)	10
MDC1	8	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, pull down, affinity chromatography technology, imaging technique	Xu X (2003), Goldberg M (2003), Goldberg M (2003), Lukas C (2004), Cha H (2010), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Lou Z (2004), Hari FJ (2010), Lu CS (2012), Wu L (2008), Wu L (2008), Wu L (2008), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008)	18
RHNO1	1	RAD9A	1	affinity chromatography technology, affinity chromatography technology	Cotta-Ramusino C (2011), Cotta-Ramusino C (2011)	2
BRCA1	7	HSPA5	0	affinity chromatography technology	Ertych N (2016)	1
ACAT1	1	ERCC2	4	biochemical	Wan C (2015)	1
ATR	6	TOPBP1	5	affinity chromatography technology	Rendtlew Danielsen JM (2009)	1
BRCA1	7	BACH1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cantor SB (2001), Cantor SB (2001), Kumaraswamy E (2007), Kumaraswamy E (2007), Shiozaki EN (2004), Shiozaki EN (2004), Greenberg RA (2006), Greenberg RA (2006), Sy SM (2009), Wang B (2007), Wang B (2007), Wang B (2007), Botuyan MV (2004), Botuyan MV (2004), Hu Y (2014)	15
TOPBP1	5	ACTG1	5	affinity chromatography technology	Wang J (2013)	1
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
POLE	10	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
MDC1	8	ATM	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Xu X (2003), Kolas NK (2007), Stewart GS (2003), Stewart GS (2003), Rassoolzadeh H (2015)	5
ESR1	0	BARD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dizin E (2010), Dizin E (2010), Liu Y (2015)	3
PMS2	4	UBR5	13	affinity chromatography technology	Cannavo E (2007)	1
TOPBP1	5	TOPBP1	5	affinity chromatography technology	Liu K (2006)	1
SMARCA4	19	TOPBP1	5	affinity chromatography technology	Cohen SM (2010)	1
BACH1	3	TOPBP1	5	affinity chromatography technology	Greenberg RA (2006)	1
EGLN3	0	UBR5	13	affinity chromatography technology	Rodriguez J (2016)	1
TOPBP1	5	GINS1	0	two hybrid	Tanaka S (2013)	1
NBN	1	BRIP1	2	affinity chromatography technology	Suhasini AN (2013)	1
TNFAIP2	2	TOPBP1	5	biochemical	Havugimana PC (2012)	1
RPAP2	3	TOPBP1	5	affinity chromatography technology	Jeronimo C (2007)	1
BRIP1	2	BLM	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Suhasini AN (2011), Suhasini AN (2011), Suhasini AN (2011), Suhasini AN (2011), Sommers JA (2014)	5
EGLN3	0	BACH1	3	affinity chromatography technology	Rodriguez J (2016)	1
SMARCA4	19	MDC1	8	biochemical	Wan C (2015)	1
ESR1	0	TOPBP1	5	pull down	Nalvarte I (2010)	1
MSH6	2	BLM	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Yang Q (2004), Yang Q (2004)	3
DTD1	0	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Chowdhury A (2010), Chowdhury A (2010)	2
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
MSH6	2	CHEK1	2	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
ATM	9	DCAF1	5	enzymatic study	Kim K (2012)	1
RPA1	0	SMC4	2	affinity chromatography technology	Marechal A (2014)	1
BRCA1	7	RPA1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Suhasini AN (2011), Mok MT (2010), Tian F (2013)	3
PPP1CC	2	HSPA5	0	affinity chromatography technology	Cid C (2007)	1
EGLN3	0	TOPBP1	5	affinity chromatography technology	Rodriguez J (2016)	1
SLX4	6	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), So J (2015)	5
SLX4	6	TOPBP1	5	affinity chromatography technology	Gritenaite D (2014)	1
HSPA5	0	ACTG1	5	affinity chromatography technology	Li J (2013)	1
PML	7	TOP2B	9	affinity chromatography technology	McNamara S (2008)	1
EGLN3	0	HSPA8	4	affinity chromatography technology	Rodriguez J (2016)	1
TOPBP1	5	RPA1	0	imaging technique	Gong Z (2010)	1
DTD1	0	CDC45	1	affinity chromatography technology, affinity chromatography technology	Chowdhury A (2010), Chowdhury A (2010)	2
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
RMI1	0	BLM	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deans AJ (2009), Wang J (2013), Hein MY (2015)	3
PMS2	4	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
BRCA1	7	PMS2	4	affinity chromatography technology	Hill SJ (2014)	1
SLX4	6	ERCC1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Kim Y (2013), Huttlin EL (2015), Perez-Oliva AB (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	12
CHEK1	2	BLM	2	affinity chromatography technology, imaging technique, genetic interference	Sengupta S (2004), Sengupta S (2004), Srivas R (2016)	3
EGLN3	0	CDC45	1	affinity chromatography technology	Rodriguez J (2016)	1
POLE	10	DDB1	6	affinity chromatography technology	Moiseeva TN (2016)	1
TOPBP1	5	BRIP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gong Z (2010), Gong Z (2010), Gong Z (2010), Gong Z (2010), Sakasai R (2012), Sakasai R (2012), Guo M (2014)	7
SLX4	6	DDB1	6	affinity chromatography technology	Ghosal G (2012)	1
DDB1	6	ABL1	9	affinity chromatography technology	Cong F (2002)	1
CDO1	2	TOPBP1	5	affinity chromatography technology	Huttlin EL (2017)	1
TFAP4	3	BRCA1	7	affinity chromatography technology	Ku WC (2009)	1
NBN	1	CHEK1	2	genetic interference	Pichierri P (2004)	1
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
EGLN3	0	PML	7	affinity chromatography technology	Rodriguez J (2016)	1
CDC45	1	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Chowdhury A (2010), Chowdhury A (2010)	2
SMARCAD1	1	SMARCA4	19	affinity chromatography technology	Rowbotham SP (2011)	1
AKT1	1	CHEK1	2	genetic interference	Shen JP (2017)	1
RPA1	0	HSPA5	0	affinity chromatography technology	Marechal A (2014)	1
ATR	6	E2F1	0	enzymatic study	Lin WC (2001)	1
BRIP1	2	BRCA1	7	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Botuyan MV (2004), Botuyan MV (2004), Botuyan MV (2004), Joo WS (2002), Yu X (2003), Yu X (2003), Rodriguez M (2003), Rodriguez M (2003), Clapperton JA (2004), Clapperton JA (2004), Yu X (2003), Kim H (2007), Sobhian B (2007), Suhasini AN (2011), Xie J (2010), Peng M (2007), Peng M (2007), Gupta R (2007), Nelson AC (2010), Nelson AC (2010), Nomine Y (2008), Dohrn L (2012), Drikos I (2009), Tischkowitz M (2008), Campbell SJ (2010), Hill SJ (2014), Wu W (2016), Suhasini AN (2013), Sakasai R (2012), Guo M (2014), Ertych N (2016)	31
BARD1	4	NBN	1	biochemical, affinity chromatography technology	Greenberg RA (2006), Greenberg RA (2006)	2
EGLN3	0	RPAP2	3	affinity chromatography technology	Rodriguez J (2016)	1
NBN	1	BLM	2	biochemical	Wang Y (2000)	1
BRIP1	2	RPA1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down	Gong Z (2010), Gupta R (2007), Gupta R (2007), Gupta R (2007), Gupta R (2007)	5
RPA1	0	MDC1	8	affinity chromatography technology	Marechal A (2014)	1
EGLN3	0	PLK1	0	affinity chromatography technology	Rodriguez J (2016)	1
TOPBP1	5	MDC1	8	biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Wang J (2011), Wang J (2011), Wang J (2011), Wang J (2013)	4
EGLN3	0	BRCA1	7	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TICRR	5	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	RMI1	0	affinity chromatography technology	Rodriguez J (2016)	1
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
TOPBP1	5	HSPA5	0	affinity chromatography technology	Wang J (2013)	1
EGLN3	0	SLX4	6	affinity chromatography technology	Rodriguez J (2016)	1
CBLN4	2	TOPBP1	5	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	NBN	1	biochemical, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Shimada M (2009), Chen L (2008), Hill SJ (2014), Goldstein M (2015), Goldstein M (2015), Parameswaran B (2015)	9
BRCA1	7	E2F1	0	affinity chromatography technology	Gorski JJ (2011)	1
BRCA1	7	ATRIP	1	affinity chromatography technology, pull down, x-ray crystallography	Venere M (2007), Liu X (2013), Liu X (2013)	3
RAD9A	1	RPA1	0	affinity chromatography technology	Wu X (2005)	1
TELO2	6	TOPBP1	5	affinity chromatography technology	Rendtlew Danielsen JM (2009)	1
8339	0	PMS2	4	bioid	Lambert JP (2015)	1
NBN	1	MSH6	2	biochemical	Wang Y (2000)	1
ATM	9	ABL1	9	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study	Shafman T (1997), Chen G (1999), Chen G (1999), Kishi S (2001), Kishi S (2001), Shafman T (1997), Shafman T (1997), Hunt CR (2007), Wang X (2011), Baskaran R (1997)	10
BRCA1	7	MSH6	2	two hybrid, pull down, biochemical, affinity chromatography technology	Wang Q (2001), Wang Q (2001), Wang Y (2000), Hill SJ (2014)	4
AKT1	1	HSPA5	0	affinity chromatography technology	Klein JB (2005)	1
E2F1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Liu W (2012), Liu W (2012)	2
RPA1	0	TOP2B	9	affinity chromatography technology	Marechal A (2014)	1
PPP1CC	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cid C (2007), Cid C (2007), Fardilha M (2011)	3
ESR1	0	SMC4	2	affinity chromatography technology	Li W (2015)	1
TOPBP1	5	E2F1	0	affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Liu K (2003), Liu K (2003), Yu X (2003), Liu K (2003), Guo R (2010), Liu K (2006)	6
ESR1	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fan M (2005), Tateishi Y (2004), Ambrosino C (2010), Tarallo R (2011), Gebauer M (1998), Dhamad AE (2016), Dhamad AE (2016)	7
E2F1	0	DDB1	6	affinity chromatography technology	Hayes S (1998)	1
TOPBP1	5	RMI1	0	affinity chromatography technology	Wang J (2013)	1
ATRIP	1	ATM	9	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
BARD1	4	TOPBP1	5	biochemical, affinity chromatography technology	Greenberg RA (2006), Greenberg RA (2006)	2
TOPBP1	5	ERCC2	4	biochemical	Wan C (2015)	1
TOPBP1	5	HSPA8	4	affinity chromatography technology	Wang J (2013)	1
DDB1	6	ESR1	0	affinity chromatography technology	Ohtake F (2007)	1
TOPBP1	5	HDLBP	9	biochemical	Havugimana PC (2012)	1
PMS2	4	SMARCA4	19	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	RPAP2	3	affinity chromatography technology	Woods NT (2012)	1
ERCC1	1	ACAT1	1	biochemical	Wan C (2015)	1
ABL1	9	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, fluorescent resonance energy transfe	Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Morell M (2007)	6
MDC1	8	BARD1	4	affinity chromatography technology	Lou Z (2003)	1
CHEK1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leung-Pineda V (2009), Leung-Pineda V (2009), Huh J (2013), Williamson EA (2014)	4
SLX4	6	MSH6	2	affinity chromatography technology	Ghosal G (2012)	1
ATR	6	ABL1	9	unspecified method, affinity chromatography technology, enzymatic study	Kim ST (1999), Wang X (2011), Wang X (2011)	3
EGLN3	0	DDB1	6	affinity chromatography technology	Rodriguez J (2016)	1
SMARCAD1	1	MSH6	2	affinity chromatography technology	Rowbotham SP (2011)	1
MSH6	2	ATM	9	biochemical	Wang Y (2000)	1
PPP1CC	2	ACTG1	5	affinity chromatography technology, affinity chromatography technology	Fardilha M (2011), Hein MY (2015)	2
ATR	6	RAD9A	1	affinity chromatography technology	Pabla N (2008)	1
RPA1	0	NBN	1	affinity chromatography technology	Marechal A (2014)	1
TFAP4	3	TOPBP1	5	affinity chromatography technology	Ku WC (2009)	1
ERCC1	1	RPA1	0	fluorescent resonance energy transfe	Friboulet L (2013)	1
ATRIP	1	NBN	1	affinity chromatography technology	Falck J (2005)	1
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
RPA1	0	DDB1	6	affinity chromatography technology	Marechal A (2014)	1
BRCA1	7	ACTG1	5	two hybrid	Woods NT (2012)	1
SMARCA4	19	PML	7	imaging technique	Chuang YS (2011)	1
PML	7	TOPBP1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu ZX (2003), Xu ZX (2003), Perfettini JL (2009), Perfettini JL (2009)	4
ATR	6	DCAF1	5	enzymatic study	Kim K (2012)	1
ATM	9	NBN	1	unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Cariveau MJ (2007), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Wu J (2012), Wei F (2015)	12
TELO2	6	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2010), Takai H (2010), Takai H (2007), Takai H (2007), Collis SJ (2007), Collis SJ (2007), Collis SJ (2007), Rendtlew Danielsen JM (2009), Rendtlew Danielsen JM (2009)	10
TOPBP1	5	DDB1	6	affinity chromatography technology	Wang J (2013)	1
BACH1	3	BARD1	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Kumaraswamy E (2007), Kumaraswamy E (2007), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Hu Y (2014)	7
HSPA5	0	HSPA8	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
EGLN3	0	SMC4	2	affinity chromatography technology	Rodriguez J (2016)	1
HSPA8	4	HDLBP	9	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	TOP2B	9	affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Tarallo R (2011)	2
HSPA8	4	ABL1	9	pull down, affinity chromatography technology	Tsukahara F (2010), Tsukahara F (2010)	2
BARD1	4	UBR5	13	two hybrid	Woods NT (2012)	1
EGLN3	0	TELO2	6	affinity chromatography technology	Rodriguez J (2016)	1
PPP1CC	2	RPAP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBR5	13	TOPBP1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Honda Y (2002), Honda Y (2002), Honda Y (2002), Honda Y (2002)	4
ATM	9	HSPA8	4	two hybrid	Arroyo R (2015)	1
MSH6	2	ATR	6	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
RHNO1	1	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Cotta-Ramusino C (2011), Cotta-Ramusino C (2011)	2
TOPBP1	5	CHEK1	2	enzymatic study	Choi JH (2007)	1
ATM	9	RPA1	0	enzymatic study	Chan DW (2000)	1
ACAT1	1	DDB1	6	biochemical	Wan C (2015)	1
BACH1	3	NBN	1	affinity chromatography technology	Greenberg RA (2006)	1
PLK1	0	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ESR1	0	HDLBP	9	pull down	Nalvarte I (2010)	1
TOPBP1	5	NBN	1	affinity chromatography technology, affinity chromatography technology	Morishima K (2007), Morishima K (2007)	2
ZBTB17	2	TOPBP1	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herold S (2002), Herold S (2002), Herold S (2002), Herold S (2002), Liu K (2006), Herold S (2008)	6
TOPBP1	5	TICRR	5	two hybrid, affinity chromatography technology	Boos D (2011), Boos D (2011)	2
BARD1	4	MSH6	2	pull down, biochemical	Wang Q (2001), Greenberg RA (2006)	2
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
8339	0	BRCA1	7	bioid	Lambert JP (2015)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
BRCA1	7	AKT1	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down	Altiok S (1999), Xiang T (2008), Xiang T (2008), Xiang T (2008), Xiang T (2011)	5
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
ATM	9	BLM	2	biochemical, pull down, affinity chromatography technology	Wang Y (2000), Beamish H (2002), Beamish H (2002)	3
SLX4	6	NBN	1	affinity chromatography technology	Ouyang J (2015)	1
TOPBP1	5	DCAF1	5	affinity chromatography technology	Wang J (2013)	1
RPA1	0	HSPA8	4	affinity chromatography technology	Marechal A (2014)	1
ATRIP	1	RPA1	0	imaging technique, pull down, affinity chromatography technology, pull down, pull down	Zou L (2003), Liu Y (2011), Marechal A (2014), Tomida J (2013), Shigechi T (2012)	5
ATR	6	BRCA1	7	pull down, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tibbetts RS (2000), Kim ST (1999), Mu JJ (2007), Chen J (2000), Chen J (2000), Tibbetts RS (2000), Gatei M (2001), Gatei M (2001), Gatei M (2001), Tian F (2013)	10
EGLN3	0	PPP1CC	2	affinity chromatography technology	Rodriguez J (2016)	1
DCAF1	5	UBR5	13	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009)	2
MDC1	8	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Matsuoka S (2007), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Lou Z (2003), Mok MT (2010), Au WW (2005)	7
BLM	2	ATR	6	affinity chromatography technology, affinity chromatography technology, enzymatic study	Davies SL (2004), Davies SL (2004), Davies SL (2004)	3
SLX4	6	RPA1	0	affinity chromatography technology	Ouyang J (2015)	1
CHEK1	2	SMARCA4	19	genetic interference	Shen JP (2017)	1
SMARCA4	19	ESR1	0	two hybrid, pull down	Ichinose H (1997), DiRenzo J (2000)	2
BRCA1	7	SMARCA4	19	affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Hill DA (2004), Bochar DA (2000), Bochar DA (2000), Bochar DA (2000), Tu Z (2013), Ertych N (2016)	6
RPA1	0	PPP1CC	2	affinity chromatography technology	Marechal A (2014)	1