PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FAM46A	2	PRSS23	1	affinity chromatography technology	Hein MY (2015)	1
GATD1	1	APP	1	pull down	Olah J (2011)	1
PRSS23	1	NOC4L	3	two hybrid	Stelzl U (2005)	1
PRSS23	1	GRK6	3	two hybrid	Stelzl U (2005)	1
PRSS23	1	PPIA	0	two hybrid	Stelzl U (2005)	1
PRSS23	1	EFNA3	0	two hybrid	Stelzl U (2005)	1
TRAPPC4	2	APP	1	pull down	Olah J (2011)	1
PRSS23	1	RECQL4	5	two hybrid	Stelzl U (2005)	1
PRSS23	1	MAPK8IP2	5	two hybrid	Stelzl U (2005)	1
PRSS23	1	ACTG1	5	two hybrid	Stelzl U (2005)	1
ODF2L	4	APP	1	pull down	Olah J (2011)	1
PRSS23	1	TCF12	14	two hybrid	Stelzl U (2005)	1
ELAVL1	0	TCF12	14	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	FAM46A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK8IP2	5	CRP	0	two hybrid	Grossmann A (2015)	1
ELAVL1	0	ACTB	8	affinity chromatography technology	Abdelmohsen K (2009)	1
RECQL4	5	UBR1	3	biochemical, affinity chromatography technology, affinity chromatography technology	Yin J (2004), Yin J (2004), Yin J (2004)	3
PPIA	0	APP	1	pull down	Olah J (2011)	1
CRP	0	PRSS23	1	affinity chromatography technology	Huttlin EL (2017)	1
PRSS23	1	SLC25A6	3	two hybrid	Stelzl U (2005)	1
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
KLRG2	2	PRSS23	1	affinity chromatography technology	Huttlin EL (2017)	1
PRSS23	1	COL5A1	1	affinity chromatography technology	Huttlin EL (2017)	1
PRSS23	1	NCAPD3	6	two hybrid	Stelzl U (2005)	1
SRPRA	3	PRSS23	1	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	PPIA	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PRSS23	1	RACGAP1	2	two hybrid	Stelzl U (2005)	1
PRSS23	1	TMEM222	1	two hybrid	Stelzl U (2005)	1
PDPK1	0	APP	1	pull down	Olah J (2011)	1
PRSS23	1	LRP2	13	affinity chromatography technology	Huttlin EL (2015)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
PRSS23	1	PHF23	3	two hybrid	Stelzl U (2005)	1
ELAVL1	0	CHP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BAX	3	PRSS23	1	affinity chromatography technology	Hein MY (2015)	1
PRSS23	1	HSPA4	3	two hybrid	Stelzl U (2005)	1
PRSS23	1	GATD1	1	two hybrid	Stelzl U (2005)	1
PRSS23	1	ACTB	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRSS23	1	158345	0	two hybrid	Stelzl U (2005)	1
PRSS23	1	FXR1	0	two hybrid	Stelzl U (2005)	1
PRSS23	1	SHMT1	1	two hybrid	Stelzl U (2005)	1
CTR9	10	PRSS23	1	affinity chromatography technology	Hein MY (2015)	1
LRP2	13	MAPK8IP2	5	two hybrid, pull down, two hybrid	Gotthardt M (2000), Gotthardt M (2000), Petersen HH (2003)	3
PRSS23	1	UBR1	3	affinity chromatography technology	Huttlin EL (2017)	1
SCGB2A2	0	PRSS23	1	affinity chromatography technology	Huttlin EL (2017)	1
BAX	3	HSPA4	3	affinity chromatography technology	Guo F (2005)	1
ACTB	8	ACTG1	5	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
PRSS23	1	PDPK1	0	two hybrid	Stelzl U (2005)	1
ELAVL1	0	PRSS23	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PRSS23	1	CHP1	0	two hybrid	Stelzl U (2005)	1
PRSS23	1	567	0	two hybrid	Stelzl U (2005)	1
ELAVL1	0	FXR1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PRSS23	1	APP	1	pull down	Olah J (2011)	1
PRSS23	1	NIPBL	10	two hybrid	Stelzl U (2005)	1
NOP9	1	PRSS23	1	affinity chromatography technology	Hein MY (2015)	1
PRSS23	1	TRAPPC4	2	two hybrid	Stelzl U (2005)	1
APP	1	MAPK8IP2	5	affinity chromatography technology	Muresan Z (2005)	1
PRSS23	1	ODF2L	4	two hybrid	Stelzl U (2005)	1