PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	RTEL1	9	affinity chromatography technology	Bennett EJ (2010)	1
KATNA1	0	SORBS3	5	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	KLHL42	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cummings CM (2009), Cummings CM (2009), Bennett EJ (2010), Plafker KS (2009), Olma MH (2009), Wimuttisuk W (2014), Huttlin EL (2017)	7
KATNA1	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Yang SW (2013), Yang SW (2013)	2
DYNC1H1	41	HSPA1A	0	affinity chromatography technology	Hein MY (2015)	1
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
LATS1	3	APP	1	pull down	Olah J (2011)	1
ODF2	1	APP	1	pull down	Olah J (2011)	1
DYNC1H1	41	KATNB1	0	pull down, affinity chromatography technology	Toyo-Oka K (2005), Toyo-Oka K (2005)	2
ARIH1	3	CUL3	17	affinity chromatography technology	Kelsall IR (2013)	1
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
SH3KBP1	1	KATNB1	0	affinity chromatography technology	Havrylov S (2009)	1
NDEL1	2	KATNA1	0	pull down, affinity chromatography technology	Toyo-Oka K (2005), Toyo-Oka K (2005)	2
SSX2IP	0	KATNB1	0	bioid	Gupta GD (2015)	1
KATNA1	0	USP47	4	affinity chromatography technology, affinity chromatography technology	Yang SW (2013), Yang SW (2013)	2
PAFAH1B1	3	KATNA1	0	pull down, affinity chromatography technology	Toyo-Oka K (2005), Toyo-Oka K (2005)	2
HSPA1A	0	SRSF2	0	biochemical	Havugimana PC (2012)	1
KATNA1	0	DCAF1	5	affinity chromatography technology, pull down, enzymatic study	Maddika S (2009), Maddika S (2009), Maddika S (2009)	3
KATNA1	0	SLC30A7	0	affinity chromatography technology	Hein MY (2015)	1
SSX2IP	0	NDEL1	2	bioid	Gupta GD (2015)	1
CCT7	2	KATNB1	0	affinity chromatography technology	Huttlin EL (2017)	1
GOLT1B	0	SOAT1	3	affinity chromatography technology	Hein MY (2015)	1
KATNA1	0	CCDC88C	7	affinity chromatography technology	Hein MY (2015)	1
KATNA1	0	SRPRA	3	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	ASB3	0	affinity chromatography technology	Taipale M (2012)	1
KATNA1	0	SRSF2	0	affinity chromatography technology	Hein MY (2015)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
KATNA1	0	KATNB1	0	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hartman JJ (1998), Hartman JJ (1998), Hartman JJ (1998), Toyo-Oka K (2005), Toyo-Oka K (2005), Toyo-Oka K (2005), Toyo-Oka K (2005), Havugimana PC (2012), Hein MY (2015), Huttlin EL (2017)	10
CUL3	17	SRPRB	0	affinity chromatography technology	Bennett EJ (2010)	1
LATS1	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
KATNA1	0	ARHGAP39	2	affinity chromatography technology	Hein MY (2015)	1
LACRT	1	APP	1	pull down	Olah J (2011)	1
NDEL1	2	KATNB1	0	pull down, affinity chromatography technology	Toyo-Oka K (2005), Toyo-Oka K (2005)	2
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
CUL3	17	SRSF2	0	affinity chromatography technology	Bennett EJ (2010)	1
KATNA1	0	HSP90AA1	7	affinity chromatography technology	Yang SW (2013)	1
KATNA1	0	GOLT1B	0	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	DYNC1H1	41	affinity chromatography technology	Bennett EJ (2010)	1
PAFAH1B1	3	KATNB1	0	pull down, affinity chromatography technology	Toyo-Oka K (2005), Toyo-Oka K (2005)	2
KATNA1	0	SRPRB	0	affinity chromatography technology	Hein MY (2015)	1
KATNA1	0	ENOPH1	0	affinity chromatography technology	Hein MY (2015)	1
GOLT1B	0	NCKAP5L	4	affinity chromatography technology	Hein MY (2015)	1
KATNA1	0	DYRK2	1	affinity chromatography technology, enzymatic study	Maddika S (2009), Maddika S (2009)	2
ODF2	1	SSX2IP	0	bioid	Gupta GD (2015)	1
SH3KBP1	1	KATNA1	0	affinity chromatography technology	Havrylov S (2009)	1
CUL3	17	SPTBN1	6	affinity chromatography technology	Bennett EJ (2010)	1
INPP5K	6	USP47	4	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CLU	1	KATNA1	0	two hybrid	Moretti RM (2007)	1
KATNA1	0	USP1	4	affinity chromatography technology	Hein MY (2015)	1
KATNA1	0	LACRT	1	affinity chromatography technology	Huttlin EL (2017)	1
SRPRB	0	SRPRA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
HSP90AA1	7	DYNC1H1	41	affinity chromatography technology	Gano JJ (2010)	1
CUL3	17	UBR5	13	affinity chromatography technology	Bennett EJ (2010)	1
CLK1	1	CUL3	17	enzymatic study	Lipp JJ (2015)	1
KATNA1	0	MAPT	1	affinity chromatography technology	Hein MY (2015)	1
INPP5K	6	KATNA1	0	affinity chromatography technology	Huttlin EL (2017)	1
PFDN4	0	KATNB1	0	affinity chromatography technology	Huttlin EL (2017)	1
KATNBL1	0	KATNB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STUB1	4	CCT7	2	biochemical	Wan C (2015)	1
KATNA1	0	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
KATNA1	0	HSPA1A	0	affinity chromatography technology	Yang SW (2013)	1
PAFAH1B1	3	DYNC1H1	41	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Tai CY (2002), Tai CY (2002), Tai CY (2002), Ding C (2009), Yamada M (2008), Caspi M (2003), Wan C (2015), Hein MY (2015), Boldt K (2016)	9
KATNA1	0	RTEL1	9	affinity chromatography technology	Hein MY (2015)	1
ODF2	1	KATNA1	0	bioid	Gupta GD (2015)	1
KLHL42	1	SSX2IP	0	two hybrid	Rolland T (2014)	1
SSX2IP	0	KATNA1	0	bioid	Gupta GD (2015)	1
KATNA1	0	SRSF3	5	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CUL3	17	HSPA1A	0	affinity chromatography technology	Bennett EJ (2010)	1
KATNA1	0	AKR7A2	1	affinity chromatography technology	Hein MY (2015)	1
DYRK2	1	UBR5	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
CUL3	17	SRSF3	5	affinity chromatography technology	Bennett EJ (2010)	1
NDEL1	2	PAFAH1B1	3	two hybrid, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Toyo-oka K (2003), Toyo-oka K (2003), Niethammer M (2000), Niethammer M (2000), Niethammer M (2000), Ding C (2009), Liang Y (2004), Caspi M (2003), Caspi M (2003), Caspi M (2003), Huttlin EL (2017), Boldt K (2016)	12
KATNA1	0	CAPN1	3	affinity chromatography technology	Hein MY (2015)	1
DYRK2	1	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
ASB3	0	KATNA1	0	affinity chromatography technology	Huttlin EL (2017)	1
KATNA1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, biochemical	Cummings CM (2009), Cummings CM (2009), Wan C (2015)	3
DYRK2	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
KATNA1	0	DDB1	6	affinity chromatography technology	Maddika S (2009)	1
MAPT	1	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Dickey CA (2008), Hatakeyama S (2004), Hatakeyama S (2004), Hatakeyama S (2004), Petrucelli L (2004), Dolan PJ (2010), Dolan PJ (2010), Shimura H (2004), Shimura H (2004), Shimura H (2004), Dickey CA (2007), Sakagami Y (2013), Ozdemir AY (2013), Grelle G (2006), Grelle G (2006)	15
NDEL1	2	DYNC1H1	41	affinity chromatography technology, biochemical, affinity chromatography technology	Niethammer M (2000), Yamada M (2008), Liang Y (2004)	3
APP	1	KATNA1	0	pull down	Virok DP (2011)	1
ASB3	0	KATNB1	0	affinity chromatography technology	Huttlin EL (2017)	1
ARIH1	3	KATNA1	0	affinity chromatography technology	Huttlin EL (2017)	1
SRSF3	5	SRSF2	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
DYNC1H1	41	KATNA1	0	pull down, affinity chromatography technology	Toyo-Oka K (2005), Toyo-Oka K (2005)	2
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
MAPT	1	HSPA1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012), Ozdemir AY (2013)	4
KATNA1	0	SPTBN1	6	affinity chromatography technology	Hein MY (2015)	1
APP	1	CLU	1	pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology	Hammad SM (1997), Ghiso J (1993), Chen P (2013), Chen P (2013)	4
SRSF3	5	APP	1	pull down	Olah J (2011)	1
PFDN4	0	KATNA1	0	affinity chromatography technology	Huttlin EL (2017)	1
DYRK2	1	HSPA1A	0	affinity chromatography technology	Maddika S (2009)	1
PAFAH1B1	3	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology	Zhu XJ (2010), Zhu XJ (2010), Yang Y (2010)	3
KLHL42	1	KATNA1	0	affinity chromatography technology	Cummings CM (2009)	1
KATNA1	0	LATS1	3	affinity chromatography technology	Hein MY (2015)	1
CCT7	2	APP	1	pull down	Olah J (2011)	1
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
NDEL1	2	APP	1	pull down	Olah J (2011)	1
CLK1	1	SRSF3	5	two hybrid	Tai HH (2003)	1
CCDC88C	7	APP	1	pull down	Olah J (2011)	1
DYRK2	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Taipale M (2012)	2
ODF2	1	NCKAP5L	4	bioid	Gupta GD (2015)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
CUL3	17	CCT7	2	affinity chromatography technology	Bennett EJ (2010)	1
CLK1	1	KATNA1	0	enzymatic study	Lipp JJ (2015)	1
KATNA1	0	SOAT1	3	affinity chromatography technology	Hein MY (2015)	1
DYRK2	1	DDB1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
KATNA1	0	CCT7	2	affinity chromatography technology	Huttlin EL (2017)	1
DCAF1	5	UBR5	13	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009)	2
KATNBL1	0	KATNA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
SSX2IP	0	CCT7	2	bioid	Gupta GD (2015)	1
KATNA1	0	NCKAP5L	4	affinity chromatography technology	Hein MY (2015)	1