PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	ATP2A2	7	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Li J (2013)	2
CUL3	17	PTPRT	9	affinity chromatography technology	Bennett EJ (2010)	1
PTPRT	9	PHKB	0	bioid	St-Denis N (2016)	1
CUL3	17	ATP2A2	7	affinity chromatography technology	Bennett EJ (2010)	1
PTPRT	9	PHKA1	0	bioid	St-Denis N (2016)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
EGFR	5	PTPRT	9	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
ERBB2	6	PTPRT	9	two hybrid	Yao Z (2017)	1
PTPRT	9	ATP2A2	7	affinity chromatography technology	St-Denis N (2016)	1
ERBB4	5	PTPRT	9	two hybrid	Yao Z (2017)	1