PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FAM107A	0	PLSCR1	0	two hybrid	Mu P (2017)	1
FAM107A	0	EIF4A1	3	two hybrid	Mu P (2017)	1
CCDC85B	0	FAM107A	0	two hybrid	Rual JF (2005)	1
KRT15	2	USHBP1	1	two hybrid	Rual JF (2005)	1
FAM107A	0	IQUB	6	two hybrid	Mu P (2017)	1
FAM107A	0	PSMD6	0	two hybrid	Mu P (2017)	1
FAM107A	0	DCD	0	affinity chromatography technology	Ewing RM (2007)	1
PLSCR1	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
FAM107A	0	BEGAIN	3	two hybrid	Rual JF (2005)	1
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
TADA2A	1	FAM107A	0	two hybrid	Rual JF (2005)	1
FAM107A	0	NINL	1	two hybrid	Rual JF (2005)	1
CCDC85B	0	LDOC1	0	two hybrid	Rual JF (2005)	1
FAM107A	0	CCDC136	1	two hybrid	Rolland T (2014)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
USHBP1	1	KRT40	0	two hybrid	Rolland T (2014)	1
FAM107A	0	MEIOB	1	two hybrid	Mu P (2017)	1
FAM107A	0	SKIV2L2	0	two hybrid	Mu P (2017)	1
FAM107A	0	AGMAT	0	two hybrid	Mu P (2017)	1
KRT15	2	KRT19	0	two hybrid	Rual JF (2005)	1
FAM107A	0	SSFA2	3	two hybrid	Mu P (2017)	1
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
PNMA1	0	ACTB	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
PNMA1	0	FAM107A	0	two hybrid	Rolland T (2014)	1
TRAF2	1	IQUB	6	two hybrid	Rolland T (2014)	1
FKBP6	1	LZTS2	4	two hybrid	Rolland T (2014)	1
NEXN	3	ACTB	8	affinity chromatography technology	Huttlin EL (2017)	1
FAM107A	0	HOOK2	0	two hybrid	Rual JF (2005)	1
FAM107A	0	COMMD1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Mu P (2017), Mu P (2017), Mu P (2017), Mu P (2017)	4
FAM107A	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
FAM107A	0	EFHC2	0	two hybrid	Mu P (2017)	1
KRT15	2	FAM107A	0	two hybrid	Rual JF (2005)	1
PPP2R2A	0	SKIV2L2	0	affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Yadav L (2017), Yadav L (2017)	3
HSPD1	0	LZTS2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
FAM107A	0	NEXN	3	two hybrid	Mu P (2017)	1
FAM107A	0	FKBP6	1	two hybrid	Mu P (2017)	1
FAM107A	0	RNLS	0	two hybrid	Mu P (2017)	1
FAM107A	0	POMP	1	two hybrid	Mu P (2017)	1
FAM107A	0	BIRC8	0	two hybrid	Mu P (2017)	1
FAM107A	0	HSPA14	0	two hybrid	Mu P (2017)	1
FAM107A	0	RAB18	1	two hybrid	Mu P (2017)	1
FAM107A	0	AZI2	1	two hybrid	Mu P (2017)	1
FAM107A	0	ACTB	8	imaging technique, affinity chromatography technology	Mu P (2017), Mu P (2017)	2
TRIM37	7	FAM107A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
FAM107A	0	SPATA22	1	two hybrid	Mu P (2017)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
FAM107A	0	RINT1	1	two hybrid	Rolland T (2014)	1
FAM107A	0	AUH	0	two hybrid	Mu P (2017)	1
FAM107A	0	APPBP2	3	two hybrid	Mu P (2017)	1
KRT40	0	IQUB	6	two hybrid	Rolland T (2014)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
CALCOCO2	0	FAM107A	0	two hybrid	Rual JF (2005)	1
FAM107A	0	PPP2R2A	0	affinity chromatography technology	Ewing RM (2007)	1
TRAF2	1	FAM107A	0	two hybrid	Rual JF (2005)	1
KRT15	2	LDOC1	0	two hybrid	Rual JF (2005)	1
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
FAM107A	0	HFM1	6	two hybrid	Mu P (2017)	1
FAM107A	0	USHBP1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MID2	1	FAM107A	0	two hybrid	Rolland T (2014)	1
CALCOCO2	0	AZI2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
FAM107A	0	LZTS2	4	two hybrid	Rolland T (2014)	1
FAM107A	0	GFM2	3	two hybrid	Mu P (2017)	1
KRT19	0	USHBP1	1	two hybrid	Rual JF (2005)	1
FAM107A	0	HSPD1	0	two hybrid	Mu P (2017)	1
VIM	0	FAM107A	0	two hybrid	Rual JF (2005)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
FAM107A	0	LDOC1	0	two hybrid	Rual JF (2005)	1
FAM107A	0	CPSF3	5	two hybrid	Mu P (2017)	1
HSPD1	0	KRT40	0	two hybrid	Rolland T (2014)	1
FAM107A	0	HTRA1	3	two hybrid	Mu P (2017)	1
APPBP2	3	DCD	0	two hybrid	Rolland T (2014)	1
FAM107A	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
KRT19	0	FAM107A	0	two hybrid	Rual JF (2005)	1
FAM107A	0	FSD2	4	two hybrid	Rolland T (2014)	1
FAM107A	0	KRT40	0	two hybrid	Rolland T (2014)	1
REV3L	8	FAM107A	0	genetic interference	Kotov IN (2014)	1